Computational model of dynein-dependent self-organization of microtubule asters

Journal of Cell Science

Volumn 117, Issue 8, 2004, Pages 1381-1397

  Cytrynbaum, E N ^a   Rodionov, V ^b   Mogilner, A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Cytoskeleton; Mathematical model; Microtubules; Mitosis; Molecular motors; Self organization

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; PIGMENT; POLYMER;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CELL ANCHORAGE; CELL GRANULE; CELL NUCLEUS; CELL POLARITY; CELL STRUCTURE; CENTROSOME; COMPUTER SIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; FISH; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MELANOPHORE; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR SIZE; MOLECULAR STABILITY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; QUANTITATIVE ANALYSIS;

ANIMALS; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DYNEIN ATPASE; FEEDBACK; FISHES; MELANOPHORES; MICROTUBULES; MODELS, BIOLOGICAL; PIGMENTS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS;

ANIMALIA; ASTER; MELANOPHORA;

EID: 2342424885     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00919     Document Type: Article

References (32)

1. Ashkin, A., Schutze, K., Dziedzic, J. M., Euteneuer, U. and Schliwa, M. (1990). Force generation of organelle transport measured in vivo by an infrared laser trap. Nature 348, 346-348.
2. Bray, D. (2001). Cell movements: from molecules to motility. New York: Garland Publ.
3. Cytrynbaum, E. N., Scholey, J. M. and Mogilner, A. (2003). A force balance model of early spindle pole separation in Drosophila embryos. Biophys. J. 84, 757-769.
4. Garcia, A. I. (1994). Numerical Methods for physicists. New Jersey: Prentice Hall.
5. Goldstein, L. S. and Philp, A. V. (1999). The road less traveled: emerging principles of kinesin motor utilization. Annu. Rev. Cell Dev. Biol. 15, 141-183.
6. Gross, S. P., Tuma, M. C., Deacon, S. W., Serpinskaya, A. S., Reilein, A. R. and Gelfand, V. I. (2002). Interactions and regulation of molecular motors in Xenopus melanophores. J. Cell Biol. 156, 855-865.
7. Heald, R., Tournebize, R., Blank, T., Sandaltzopoulos, R., Becker, P., Hyman, A. and Karsenti, E. (1996). Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382, 420-425.
8. Holy, T. E. and Leibler, S. (1994). Dynamic instability of microtubules as an efficient way to search in space. Proc. Natl. Acad. Sci. USA 91, 5682-5685.
9. Holzbaur, E. L. and Vallee, R. B. (1994). Dyneins: molecular structure and cellular function. Annu. Rev. Cell Biol. 10, 339-372.
10. Joglekar, A. P. and Hunt, A. J. (2002). A simple, mechanistic model for directional instability during mitotic chromosome movements. Biophys J. 83, 42-58.
11. Kellogg, D. R., Moritz, M. and Alberts, B. M. (1994). The centrosome and cellular organization. Annu. Rev. Biochem. 63, 639-674.
12. Lane, J. and Allan, V. (1998). Microtubule-based membrane movement. Biochim. Biophys. Acta. 1376, 27-55.
13. Maly, I. V. and Borisy, G. G. (2002). Self-organization of treadmilling microtubules into a polar array. Trends Cell Biol. 12, 462-465.
14. Maniotis, A. and Schliwa, M. (1991). Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells. Cell 67, 495-504.
15. McNiven, M. and Porter, K. R. (1988). Organization of microtubules in centrosome-free cytoplasm. J. Cell Biol. 106, 1593-1605.
16. Mitchison, T. and Kirschner, M. (1984). Dynamic instability of microtubule growth. Nature 312, 237-242.
17. Nedelec, F. J., Surrey, T., Maggs, A. C. and Leibler, S. (1997). Self-organization of microtubules and motors. Nature 389, 305-308.
18. Nedelec, F. (2002). Computer simulations reveal motor properties generating stable antiparallel microtubule interactions. J. Cell Biol. 158, 1005-1015.
19. Nedelec, F., Surrey, T. and Karsenti, E. (2003). Self-organisation and forces in the microtubule cytoskeleton. Curr. Opin. Cell Biol. 15, 118-124.
20. Rodionov, V. I., Lim, S.-S., Gelfand, V. I. and Borisy, G. G. (1994). Microtubule dynamics in fish melanophores. J. Cell Biol. 126, 1455-1464.
21. Rodionov, V. I. and Borisy, G. G. (1997a). Self-centring activity of cytoplasm. Nature 386, 170-173.
22. Rodionov, V. I. and Borisy, G. G. (1997b). Micrutubule treadmilling in vivo. Science 275, 215-218.
23. Rodionov, V. I., Hope, A. J., Svitkina, T. M. and Borisy, G. G. (1998). Functional coordination of microtubule and actin based motility in melanophores. Curr. Biol. 8, 165-168.
24. Rodionov, V. I., Nadezhdina, E. S., Peloquin, J. and Borisy, G. G. (2001). Digital fluorescence microscopy of cell cytoplasts with and without the centrosome. Methods Cell Biol. 67, 43-51.
25. Sharp, D. J., Rogers, G. C. and Scholey, J. M. (2000). Roles of motor proteins in building microtubule-based structures: a basic principle of cellular design. Biochim. Biophys. Acta. 1496, 128-141.
26. Schiebel, E. (2000). Gamma-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Curr. Opin. Cell Biol. 12, 113-118.
27. Tran, P. T., Marsh, L., Doye, V., Inoue, S. and Chang F. (2001). A mechanism for nuclear positioning in fission yeast based on microtubule pushing. J. Cell Biol. 153, 397-411.
28. Tuma, M. C. and Gelfand, V. I. (1999). Molecular mechanisms of pigment transport in melanophores. Pigment Cell Res. 12, 283-294.
29. Verde, F., Berrez, J. M., Antony, C. and Karsenti, E. (1991). Taxol-induced microtubule asters in mitotic extracts of Xenopus eggs: requirement for phosphorylated factors and cytoplasmic dynein. J. Cell Biol. 112, 1177-1187.
30. Vorobjev, I., Malikov, V. and Rodionov, V. (2001). Self-organization of a radial microtubule array by dynein-dependent nucleation of microtubules. Proc. Natl. Acad. Sci. USA 98, 10160-10165.
31. Waterman-Storer, C. M. and Salmon, E. (1999). Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr. Opin. Cell Biol. 11, 61-67.
32. Yamada, A., Yamaga, T., Sakakibara, H., Nakayama, H. and Oiwa, K. (1998). Unidirectional movement of fluorescent microtubules on rows of dynein arms of disintegrated axonems. J. Cell Sci. 111, 93-98.