Translation of NRF mRNA is mediated by highly efficient internal ribosome entry

Molecular and Cellular Biology

Volumn 20, Issue 8, 2000, Pages 2755-2759

  Oumard, A ^a   Hennecke, M ^a   Hauser, H ^a   Nourbakhsh, M ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAPPED RNA; MESSENGER RNA; NUCLEAR FACTOR KAPPA B REPRESSING FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; REGULATORY MECHANISM; RIBOSOME; RNA CAPPING; TRANSLATION REGULATION;

3T3 CELLS; 5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN BIOSYNTHESIS; REPRESSOR PROTEINS; RIBOSOMES; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0034127011     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.8.2755-2759.2000     Document Type: Article

References (25)

1. Borman, A. M., P. LeMercier, M. Girard, and K. M. Kean. 1997. Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Res. 25:925-932.
2. Dirks, W., M. Wirth, and H. Hauser. 1993. Dicistronic transcription units for gene expression in mammalian cells. Gene 128:247-249.
3. Duncan, R., S. C. Milburn, and J. W. B. Hershey. 1987. Regulated phosphorylation and low abundance of HeLa cells eIF-4E suggest a role in translational control. J. Biol. Chem. 262:380-388.
4. Ehrenfeld, E. 1996. Initiation of translation by picornavirus RNAs, p. 549-574. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.). Translation control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
5. Hershey, J. W. B. (ed.). 1996. Translation control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
6. Jackson, R. J. A. 1996. A comparative view of initiation site selection mechanisms, p. 71-112. In J. W. B. Hershey (ed.). Translation control. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
7. Kues, W. A., M. Anger, J. W. Carnwath, J. Motlik, H. Niemann, and D. Paul. 1999. Cell cycle synchronization of porcin primary fibroblasts: effects of serum withdrawal and reversible cell cycle inhibitors. Theriogenology 51:205.
8. Le, S. Y., and J. V. Maizel, Jr. 1997. A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs. Nucleic Acids Res. 25:362-369.
9. Mountford, P., B. Zevnik, A. Duwel, J. Nicols, M. Li, C. Dani, M. Robertson, E. Chamber, and A. Smith. 1994. Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc. Natl. Acad. Sci. USA 91:4303-4307.
10. Mountford, P. S., and A. G. Smith. 1995. Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis. Trends Genet. 11:179-184.
11. Negulescu, D., L. E. C. Leong, K. G. Chandy, and B. M. Semler. 1998. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J. Biol. Chem. 273:20109-20113.
12. Nourbakhsh, M., and H. Hauser. 1997. The transcriptional silencer protein NRF: a repressor of NF-kappaB enhancers. Immunobiology 198:65-72.
13. Nourbakhsh, M., and H. Hauser. 1999. Constitutive silencing of IFN-ß promoter is mediated by NRF (NF-κB repressing factor), a nuclear inhibitor of NF-κB. EMBO J. 18:6415-6425.
14. Oie, H. K., A. F. Gazdar, C. E. Buckler, and S. Baron. 1977. High Interferon producing line of transformed murine cells. J. Gen. Virol. 17:107-109.
15. Pelletier, J., and N. Sonenberg. 1985. Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell 40:515-526.
16. Sabe, H., S. Kondo, A. Shimuzu, Y. Tagaya, J. Yodoi, N. Kobayashi, M. Hatanaka, N. Matsunamim, M. Maeda, T. Noma, and T. Honjo. 1984 Properties of human interleukin-2 receptors expressed on non-lymphoid cells by cDNA transfection. Mol. Biol. Med. 2:379-396.
17. Sachs, A. B., P. Sarnow, and P. M. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831-838.
18. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
19. Sonenberg, N., and A. Gingras. 1998. The mRNA 5′ cap-binding protein eiF4E and control of cell growth. Curr. Opin. Cell Biol. 10:268-275.
20. Stein, L., A. Itin, P. Einat, R. Skaliter, Z. Grossman, and E. Keshet. 1998 Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol. Cell. Biol. 18:3112-3119.
21. Stoneley, M., F. E. M. Paulin, J. P. C. Le Quense, S. A. Chappell, and A. E. Willis. 1998. C-Myc 5′ untranslated region contains an internal ribosome entry segment. Oncogene 16:423-428.
22. Vagner, S. 1995. Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes. Mol. Cell. Biol. 15:35-44.
23. Yang, Q., and P. Sarnow. 1997. Location of the internal ribosome entry site in the 5′ non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions. Nucleic Acids Res. 25:2800-2807.
24. Yueh, A., and R. J, Schneider. 1996. Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. Genes Dev. 10:1557-1567.
25. Zuker, M. 1989. Computer prediction of RNA structure. Methods Enzymol. 180:262-288.