메뉴 건너뛰기




Volumn 27, Issue 4, 2005, Pages 478-483

Metabolic ratios of psychotropics as indication of cytochrome P450 2D6/2C19 genotype

Author keywords

CYP2C19; CYP2D6; Genetic polymorphism; Pharmacokinetics; Psychotropics

Indexed keywords

AMITRIPTYLINE; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; VENLAFAXINE;

EID: 23244462633     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ftd.0000162868.84596.c3     Document Type: Article
Times cited : (68)

References (42)
  • 1
    • 0034007388 scopus 로고    scopus 로고
    • Phenotyping of drug-metabolizing enzymes in adults: A review of in-vivo cytochrome P450 phenotyping probes
    • Streetman DS, Bertino JS Jr, Nafziger AN. Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes. Pharmacogenetics. 2000;10:187-216.
    • (2000) Pharmacogenetics , vol.10 , pp. 187-216
    • Streetman, D.S.1    Bertino Jr., J.S.2    Nafziger, A.N.3
  • 2
    • 0026610576 scopus 로고
    • Analysis of the CYP2D6 gene in relation to dcbrisoquin and desipramine liydroxylation in a Swedish population
    • Dahl ML, Johansson I, Palmertz MP, et al. Analysis of the CYP2D6 gene in relation to dcbrisoquin and desipramine liydroxylation in a Swedish population. Clin Pharmacol Ther. 1992;51:12-17.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 12-17
    • Dahl, M.L.1    Johansson, I.2    Palmertz, M.P.3
  • 3
    • 0028865992 scopus 로고
    • A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype
    • Brøsen K, de Morais SMF, Meyer UA, et al. A multifamily study on the relationship between CYP2C19 genotype and S-mephenytoin oxidation phenotype. Pharmacogenetics. 1995;5:312-317.
    • (1995) Pharmacogenetics , vol.5 , pp. 312-317
    • Brøsen, K.1    De Morais, S.M.F.2    Meyer, U.A.3
  • 4
    • 0029587180 scopus 로고
    • Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: Comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype
    • Chang M, Dahl ML, Tybring G, et al. Use of omeprazole as a probe drug for CYP2C19 phenotype in Swedish Caucasians: comparison with S-mephenytoin hydroxylation phenotype and CYP2C19 genotype. Pharmacogenetics. 1995;5:358-363.
    • (1995) Pharmacogenetics , vol.5 , pp. 358-363
    • Chang, M.1    Dahl, M.L.2    Tybring, G.3
  • 5
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • Griese EU, Zanger UM, Brudermanns U, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics. 1998;8:15-26.
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.U.1    Zanger, U.M.2    Brudermanns, U.3
  • 6
    • 18044401567 scopus 로고    scopus 로고
    • CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting
    • McElroy S, Sachse C, Brockmöller J, et al. CYP2D6 genotyping as an alternative to phenotyping for determination of metabolic status in a clinical trial setting. AAPS PharmSci. 2000;2:E33.
    • (2000) AAPS PharmSci , vol.2
    • McElroy, S.1    Sachse, C.2    Brockmöller, J.3
  • 7
    • 0037380942 scopus 로고    scopus 로고
    • Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships
    • Chou WH, Yan FX, Robbins-Weilert DK, et al. Comparison of two CYP2D6 genotyping methods and assessment of genotype-phenotype relationships. Clin Chem. 2003;49:542-551.
    • (2003) Clin Chem , vol.49 , pp. 542-551
    • Chou, W.H.1    Yan, F.X.2    Robbins-Weilert, D.K.3
  • 8
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmöller J, Bauer S, et al. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet. 1997;60:284-295.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3
  • 10
    • 2042512985 scopus 로고    scopus 로고
    • CYP2D6 genotype: Impact on adverse effects and nonresponse during treatment with antidepressants - A pilot study
    • Rau T, Wohlleben G, Wuttke H, et al. CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study. Clin Pharmacol Ther. 2004;75:386-393.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 386-393
    • Rau, T.1    Wohlleben, G.2    Wuttke, H.3
  • 11
    • 0034467571 scopus 로고    scopus 로고
    • CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients
    • Scordo MG, Spina E, Romeo P, et al. CYP2D6 genotype and antipsychotic-induced extrapyramidal side effects in schizophrenic patients. Eur J Clin Pharmacol. 2000;56:679-683.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 679-683
    • Scordo, M.G.1    Spina, E.2    Romeo, P.3
  • 12
    • 0036260111 scopus 로고    scopus 로고
    • Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: A case-control study
    • Schillevoort I, de Boer A, van der Weide J, et al. Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case-control study. Pharmacogenetics. 2002;12:235-240.
    • (2002) Pharmacogenetics , vol.12 , pp. 235-240
    • Schillevoort, I.1    De Boer, A.2    Van Der Weide, J.3
  • 13
    • 0742286803 scopus 로고    scopus 로고
    • Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
    • Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:23-37.
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , pp. 23-37
    • Zanger, U.M.1    Raimundo, S.2    Eichelbaum, M.3
  • 14
    • 3543014421 scopus 로고    scopus 로고
    • A novel intronic mutation. 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
    • Raimundo S, Toscano C, Klein K, et al. A novel intronic mutation. 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects. Clin Pharmacol Ther. 2004;76:128-138.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 128-138
    • Raimundo, S.1    Toscano, C.2    Klein, K.3
  • 15
    • 1242269894 scopus 로고    scopus 로고
    • Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: Ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
    • Kawanishi C, Lundgren S, Agren H, et al. Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study. Eur J Clin Pharmacol. 2004;59:803-807.
    • (2004) Eur J Clin Pharmacol , vol.59 , pp. 803-807
    • Kawanishi, C.1    Lundgren, S.2    Agren, H.3
  • 16
    • 0029064096 scopus 로고
    • Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
    • Dahl ML, Johansson I, Bertilsson L, et al. Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis. J Pharmacol Exp Ther. 1995;274:516-520.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 516-520
    • Dahl, M.L.1    Johansson, I.2    Bertilsson, L.3
  • 17
    • 0032716358 scopus 로고    scopus 로고
    • Allelic, genotypic and phenotypic distributions of S-mephenytoin 4′-hydroxylasc (CYP2C19) in healthy Caucasian populations of European descent throughout the world
    • Xie HG, Stein CM, Kim RB, et al. Allelic, genotypic and phenotypic distributions of S-mephenytoin 4′-hydroxylasc (CYP2C19) in healthy Caucasian populations of European descent throughout the world. Pharmacogenetics. 1999;9:539-549.
    • (1999) Pharmacogenetics , vol.9 , pp. 539-549
    • Xie, H.G.1    Stein, C.M.2    Kim, R.B.3
  • 18
    • 0028260641 scopus 로고
    • The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem. 1994;269:15419-15422.
    • (1994) J Biol Chem , vol.269 , pp. 15419-15422
    • De Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 19
    • 0032797302 scopus 로고    scopus 로고
    • A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin
    • Ibeanu GC, Blaisdell J, Ferguson RJ, et al. A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999;290:635-640.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 635-640
    • Ibeanu, G.C.1    Blaisdell, J.2    Ferguson, R.J.3
  • 20
    • 0030045095 scopus 로고    scopus 로고
    • Venlafaxine oxidation in vitro is catalysed by CYP2D6
    • Otton SV, Ball SE, Cheung SW, et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br J Clin Pharmacol. 1996;41:149-156.
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 149-156
    • Otton, S.V.1    Ball, S.E.2    Cheung, S.W.3
  • 21
    • 0032847231 scopus 로고    scopus 로고
    • Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans
    • Lessard E, Yessine MA, Hamelin BA, et al. Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans. Pharmacogenetics. 1999;9:435-443.
    • (1999) Pharmacogenetics , vol.9 , pp. 435-443
    • Lessard, E.1    Yessine, M.A.2    Hamelin, B.A.3
  • 22
    • 0033136981 scopus 로고    scopus 로고
    • O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: Effect of metabolic inhibitors and SSRI antidepressants
    • Fogelman SM, Schmider J, Venkatakrishnan K, et al. O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999; 20:480-490.
    • (1999) Neuropsychopharmacology , vol.20 , pp. 480-490
    • Fogelman, S.M.1    Schmider, J.2    Venkatakrishnan, K.3
  • 23
    • 0026469799 scopus 로고
    • Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes
    • Breyer-Pfaff U, Pfandl B, Nill K, et al. Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clin Pharmacol Ther. 1992;52:350-358.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 350-358
    • Breyer-Pfaff, U.1    Pfandl, B.2    Nill, K.3
  • 24
    • 0031908744 scopus 로고    scopus 로고
    • Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: Dominance of CYP 2C19 and 3A4
    • Venkatakrishnan K, Greenblatt DJ, von Moltke LL, et al. Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4. J Clin Pharmacol. 1998;38:112-121.
    • (1998) J Clin Pharmacol , vol.38 , pp. 112-121
    • Venkatakrishnan, K.1    Greenblatt, D.J.2    Von Moltke, L.L.3
  • 25
    • 0031949132 scopus 로고    scopus 로고
    • 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes
    • Dalen P, Dahl ML, Ruiz ML, et al. 10-Hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes. Clin Pharmacol Ther. 1998;63:444-452.
    • (1998) Clin Pharmacol Ther , vol.63 , pp. 444-452
    • Dalen, P.1    Dahl, M.L.2    Ruiz, M.L.3
  • 26
    • 0036327723 scopus 로고    scopus 로고
    • The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients
    • Shimoda K, Someya T, Yokono A, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002;22:371-378.
    • (2002) J Clin Psychopharmacol , vol.22 , pp. 371-378
    • Shimoda, K.1    Someya, T.2    Yokono, A.3
  • 27
    • 0033063442 scopus 로고    scopus 로고
    • Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
    • Fang J, Bourin M, Baker GB. Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4. Naunyn Schmiedebergs Arch Pharmacol. 1999;359:147-151.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.359 , pp. 147-151
    • Fang, J.1    Bourin, M.2    Baker, G.B.3
  • 28
    • 0033987060 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone
    • Scordo MG, Spina E, Facciola G, et al. Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone. Psychopharmacology (Berl). 1999;147:300-305.
    • (1999) Psychopharmacology (Berl) , vol.147 , pp. 300-305
    • Scordo, M.G.1    Spina, E.2    Facciola, G.3
  • 29
    • 0036869423 scopus 로고    scopus 로고
    • Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients
    • Berecz R, LLerena A, de la Rubia A, et al. Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients. Pharmacopsychiatry. 2002;35:231-234.
    • (2002) Pharmacopsychiatry , vol.35 , pp. 231-234
    • Berecz, R.1    Llerena, A.2    De La Rubia, A.3
  • 30
    • 33644492059 scopus 로고    scopus 로고
    • http://medicine.iupui.edu/flockhart, accessed May 6, 2004.
  • 31
    • 0028044085 scopus 로고
    • Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese
    • de Morais SMF, Wilkinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol. 1994;46:594-598.
    • (1994) Mol Pharmacol , vol.46 , pp. 594-598
    • De Morais, S.M.F.1    Wilkinson, G.R.2    Blaisdell, J.3
  • 32
    • 0025036544 scopus 로고
    • Multiple mutations of the human cytochrome P45011D6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes
    • Kagimoto M, Heim M, Kagimoto K, et al. Multiple mutations of the human cytochrome P45011D6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. J Biol Chem. 1990;265:17209-17214.
    • (1990) J Biol Chem , vol.265 , pp. 17209-17214
    • Kagimoto, M.1    Heim, M.2    Kagimoto, K.3
  • 33
    • 0025114258 scopus 로고
    • Identification of the primary gene defect at the cytochrome P450 CYP2D locus
    • Gough AC, Miles JS, Spurr NK, et al. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature. 1990;347:773-776.
    • (1990) Nature , vol.347 , pp. 773-776
    • Gough, A.C.1    Miles, J.S.2    Spurr, N.K.3
  • 34
    • 0033590590 scopus 로고    scopus 로고
    • Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes
    • Lundqvist E, Johansson I, Ingelman-Sundberg M. Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes. Gene. 1999;226:327-338.
    • (1999) Gene , vol.226 , pp. 327-338
    • Lundqvist, E.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 35
    • 0033871198 scopus 로고    scopus 로고
    • Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR
    • Hersberger M, Marti-Jaun J, Rentsch K, et al. Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR. Clin Chem. 2000;46: 1072-1077.
    • (2000) Clin Chem , vol.46 , pp. 1072-1077
    • Hersberger, M.1    Marti-Jaun, J.2    Rentsch, K.3
  • 36
    • 0027952870 scopus 로고
    • A high-performance liquid chromatographic method for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in biological fluids
    • Hicks DR, Wolaniuk D, Russell A, et al. A high-performance liquid chromatographic method for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in biological fluids. Ther Drug Monit. 1994; 16:100-107.
    • (1994) Ther Drug Monit , vol.16 , pp. 100-107
    • Hicks, D.R.1    Wolaniuk, D.2    Russell, A.3
  • 37
    • 0030992855 scopus 로고    scopus 로고
    • Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes
    • Olesen OV, Linnet K. Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes. Drug Metab Dispos. 1997;25:740-744.
    • (1997) Drug Metab Dispos , vol.25 , pp. 740-744
    • Olesen, O.V.1    Linnet, K.2
  • 38
    • 0034666523 scopus 로고    scopus 로고
    • Determination of risperidone and its major metabolite 9-hydroxyrisperidone in human plasma by reversed-phase liquid chromatography with ultraviolet detection
    • Avenoso A, Facciola G, Salemi M, et al. Determination of risperidone and its major metabolite 9-hydroxyrisperidone in human plasma by reversed-phase liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Sci Appl. 2000;746:173-181.
    • (2000) J Chromatogr B Biomed Sci Appl , vol.746 , pp. 173-181
    • Avenoso, A.1    Facciola, G.2    Salemi, M.3
  • 39
    • 0030860004 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
    • Marez D, Legrand M, Sabbagh N, et al. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997;7:193-202.
    • (1997) Pharmacogenetics , vol.7 , pp. 193-202
    • Marez, D.1    Legrand, M.2    Sabbagh, N.3
  • 40
    • 4344613464 scopus 로고    scopus 로고
    • Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    • Steimer W, Zöpf K, Von Amelunxen S, et al. Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers. Clin Chem. 2004;50:1623-1633.
    • (2004) Clin Chem , vol.50 , pp. 1623-1633
    • Steimer, W.1    Zöpf, K.2    Von Amelunxen, S.3
  • 41
    • 0034894010 scopus 로고    scopus 로고
    • CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: A first step towards subpopulation-specific dosages
    • Kirchheiner J, Brøsen K, Dahl ML, et al. CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages. Acta Psychiatr Scand. 2001;104:173-192.
    • (2001) Acta Psychiatr Scand , vol.104 , pp. 173-192
    • Kirchheiner, J.1    Brøsen, K.2    Dahl, M.L.3
  • 42
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • Kirchheiner J, Nickchen K, Bauer M, et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry. 2004;9:442-473.
    • (2004) Mol Psychiatry , vol.9 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.