Lymphocyte suppression by glucocorticoids with cyclosporine, tacrolimus, pentoxifylline, and mycophenolic acid

Journal of Clinical Pharmacology

Volumn 39, Issue 2, 1999, Pages 125-130

  Briggs, William A ^a   Eustace, Joseph ^a   Gimenez, Luis F ^a   Choi, Michael J ^a   Scheel Jr , Paul J ^a   Burdick, James F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; GLUCOCORTICOID; IMMUNOGLOBULIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PENTOXIFYLLINE; PHYTOHEMAGGLUTININ; PREDNISOLONE; RAPAMYCIN; TACROLIMUS; THYMIDINE;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; GRAFT REJECTION; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL;

CELLS, CULTURED; CYCLOSPORINE; DRUG COMBINATIONS; ENZYME INHIBITORS; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY FAILURE, CHRONIC; LYMPHOCYTES; METHYLPREDNISOLONE; MYCOPHENOLIC ACID; PENTOXIFYLLINE; PREDNISOLONE; TACROLIMUS;

EID: 0032935433     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912709922007660     Document Type: Article

References (23)

1. Briggs WA, Gao ZH, Gimenez LF, Scheel PJ, Choi MJ, Burdick JF: Lymphocyte responsiveness to glucocorticoids, cyclosporine, or both. J Clin Pharmacol 1996;36:707-714.
2. Briggs WA, Gao ZH, Xing JJ, Gimenez LF, Samaniego MD, Scheel PJ, Choi MJ, Burdick JF: Suppression of lymphocyte interleukin-2 receptor expression by glucocorticoids, cyclosporine, or both. J Clin Pharmacol 1996;36:931-937.
3. Briggs WA, Gao ZH, Gimenez LF, Scheel PJ, Burdick JF, Gimenez LF, Choi MJ: Differential glucocorticoid responsiveness of dialysis patients' lymphocytes. Peritoneal Dialysis International 1996;16:406-411.
4. Briggs WA, Gao ZH, Gimenez, Xing LF, Scheel PJ, Choi MJ, Burdick JF: Differential suppression of dialysis patients' lymphocyte INF-γ production by glucocorticoids and cyclosporine. Cytokine 1996;8:804-808.
5. Haynes RD: Adrenocorticotrophic hormone; adrenocortical steroids and their synthetic analogues: inhibitors of adrenocortical steroid biosynthesis. In, Gilman AG, Rail TW, Nies AS, Taylor P (eds.): Goodman and Gilman's The Pharmacologic Basis of Therapeutics. 8th ed. New York: Permagon, 1990;1431-1462.
6. Hirano T, Oka K, Takeuchi H. Sakurai E, Matsuno N, Tamaki T, Kozaki M: Clinical significance of glucocorticoid pharmacodynamics assessed by antilymphocyte action in kidney transplantation: marked difference between prednisolone and methylprednisolone. Transplantation 1994;57:1341-1348.
7. Langhoff E, Ladefoged J: Relative immunosuppressive potency of various corticosteroids measured in vitro. Eur J Clin Pharmacol 1983;25:459-462.
8. Langhoff E, Olgaard K, Ladefoged J: The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures, Int J Immunopharmacol 1987;9:469-473.
9. Jusko WJ: Corticosteroid pharmacodynamics: models for a broad array of receptor-mediated pharmacologic effects. J Clin Pharmacol 1990;30:303-310.
10. Frey BM, Frey WFJ, de Weck AL: Pharmacokinetics and pharmacodynamics of three different prednisolone prodrugs: effect on circulating lymphocyte subsets and function. J Immunol 1984;133:2479-2487.
11. Tilg H, Eibl B, Pichl M, Gachter A, et al: Immune response modulation by pentoxifylline in vitro. Transplantation 1993;56:196-201.
12. Mouthon L, Kaveri SV, Spalter SH, Lacroix-Desmazes S, Lefranc C, Desai R, Kazatchkine MD: Mechanisms of action of intravenous immune globulin in immune-mediated diseases. Clin Exp Immunol 1996;104(Suppl. 1):39.
13. Dumont FJ, Su Q: Minireview: mechanism of action of the immunosuppressant rapamycin. Life Sciences 1996;58:373-395.
14. Derendorf H, Hochhaus G, Mollmann H, et al: Receptor-based pharmacokinetic/pharmacodynamic analysis of corticosteroids. J Clin Pharmacol 1993;33:115-123.
15. Briggs WA, Gao Z-H, Xing J-J, Scheel PJ, Gimenez LF, et al: Suppression of dialysis patients' lymphocyte IL-2R expression by glucocorticoids and cyclosporine. Cytokine 1997;9:624-628.
16. Briggs WA, Gao Z-H, Xing J-J, Scheel PJ, Burdick JF: Differential glucocorticoid responsiveness of hemodialysis patients' lymphocytes. ASAIO Journal 1997;43:31-34.
17. Kirkam BW, Corkill MM, Davison SC, Panayi GS: Response to glucocorticoid treatment in rheumatoid arthritis: in vitro mediated immune assay predicts in vivo responses. J Rheumatol 1991;18:821-825.
18. Poznansky MC, Gordon ACH, Douglas JG, Krajewski AS, Wyllie AH, Grant IWB: Resistance to methylprednisolone in cultures of blood mononuclear cells from glucocorticoid-resistant asthmatic patients. Clin Sci (London) 1984;67:639-645.
19. Langhoff E, Ladefoged J: The impact of high lymphocyte sensitivity to glucocorticoids on kidney graft survival in patients treated with azathioprine and cyclosporine. Transplantation 1987;43:380-384.
20. Francis DMA, Dumble LT, Bowes L, Clunie GJA, MacDonald IM: Adverse influence of recipient lymphoid resistance to in vitro immunosuppression on the outcome of kidney transplants. Transplantation 1988;46:853-857.
21. Pollak R, Dumble LJ, Lazda VA, Maddux MS, Stormoen B, Ward M: Utility of an in vitro immunoassay to guide immunosuppressive therapy. Transplant Proc 1991;23:1113-1114.
22. Kang XX, Hirano T, Oka K, Sakurai E, Tamaki T, Kozak M: Role of altered prednisolonespecific lymphocyte sensitivity in chronic renal failure as a pharmacodynamic marker of acute allograft rejection after kidney transplantation. Eur J Clin Pharmacol 1991;41:417-423.
23. Briggs WA, Samaniego MD, Gao ZH, Xing JJ, Gimenez LF, Scheel PJ Jr, et al: Glomerulopathy patients' lymphocyte responsiveness to glucocorticoids and cyclosporine (abstract). J Amer Soc Nephrol 1996;7:1770.