Effects of dehydroepiandrosterone, Premarin and Acolbifene on histomorphology and sex steroid receptors in the rat vagina

Journal of Steroid Biochemistry and Molecular Biology

Volumn 96, Issue 2, 2005, Pages 201-215

  Berger, L ^a   El Alfy, M ^a   Martel, C ^a   Labrie, F ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Acolbifene; Androgen receptor; Antiestrogen; DHEA; EM 652; Estrogen receptor; Hormone replacement therapy; Intracrinology; Menopause; Progesterone receptor; SERM; Sexual dysfunction; Vagina

Indexed keywords

ACOLBIFENE; COLLAGEN FIBER; CONJUGATED ESTROGEN; HORMONE RECEPTOR; PRASTERONE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SEX HORMONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CONTROLLED STUDY; FEMALE; INFLAMMATION; LAMINA PROPRIA; MORPHOLOGY; MUCOUS CELL; NONHUMAN; OVARIECTOMY; RAT; SQUAMOUS EPITHELIUM; VAGINA; VAGINA EPITHELIUM;

ANIMALS; DEHYDROEPIANDROSTERONE; ESTROGENS, CONJUGATED (USP); ESTRUS; FEMALE; ORGAN SIZE; OVARIECTOMY; PIPERIDINES; PROESTRUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; VAGINA;

ANIMALIA;

EID: 23244446876     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2005.02.018     Document Type: Article

References (62)

1. B. Rossin-Amar Vaginal dryness in the menopausal woman (physiological and psychological aspects) Gynecol. Obstet. Fertil. 28 2000 245 249
2. L. Pandit, and J.G. Ouslander Postmenopausal vaginal atrophy and atrophic vaginitis Am. J. Med. Sci. 314 1997 228 231
3. F. Labrie, and Intracrinology Mol. Cell. Endocrinol. 78 1991 C113 C118
4. F. Labrie, A. Bélanger, J. Simard, V. Luu-The, and C. Labrie DHEA and peripheral androgen and estrogen formation: intracrinology Ann. N. Y. Acad. Sci. 774 1995 16 28
5. F. Labrie, V. Luu-The, C. Labrie, A. Bélanger, J. Simard, S.-X. Lin, and G. Pelletier Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone Endocr. Rev. 24 2003 152 182
6. N. Orentreich, J.L. Brind, R.L. Rizer, and J.H. Vogelman Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood J. Clin. Endocrinol. Metab. 59 1984 551 555
7. F. Labrie, A. Bélanger, L. Cusan, J.L. Gomez, and B. Candas Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging J. Clin. Endocrinol. Metab. 82 1997 2396 2402
8. M.J. Rosenberg, T.D. King, and M.C. Timmons Estrogen-androgen for hormone replacement: a review J. Reprod. Med. 42 1997 394 404
9. I.D. Burd, and G.A. Bachmann Androgen replacement in menopause Curr. Womens Health Rep. 1 2001 202 205
10. G.A. Colditz, S.E. Hankinson, D.J. Hunter, W.C. Willett, J.E. Manson, M.J. Stampfer, C. Hennekens, B. Rosner, and F.E. Speizer The use of estrogens and progestins and the risk of breast cancer in postmenopausal women N. Engl. J. Med. 332 1995 1589 1593
11. R.K. Ross, A. Paganini-Hill, P.C. Wan, and M.C. Pike Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin J. Natl. Cancer Inst. 92 2000 328 332
12. W.G.f.t.W.s.H.I. Investigators, Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial, JAMA 288 (2002) 321-333.
13. F. Labrie, P. Diamond, L. Cusan, J.L. Gomez, and A. Bélanger Effect of 12-month DHEA replacement therapy on bone, vagina, and endometrium in postmenopausal women J. Clin. Endocrinol. Metab. 82 1997 3498 3505
14. F. Labrie Dehydroepiandrosterone (DHEA) as potential hormone replacement therapy Référence en Gynécologie Obstétrique 8 2001 317 322
15. A. Lasco, N. Frisina, N. Morabito, A. Gaudio, E. Morini, A. Trifiletti, G. Basile, V. Nicita-Mauro, and D. Cucinotta Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women Eur. J. Endocrinol. 145 2002 457 461
16. S. Gauthier, B. Caron, J. Cloutier, Y.L. Dory, A. Favre, D. Larouche, J. Mailhot, C. Ouellet, A. Schwerdtfeger, G. Leblanc, C. Martel, J. Simard, Y. Mérand, A. Bélanger, C. Labrie, and F. Labrie (S)-(+)-4-[7-(2,2- dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl] -2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen J. Med. Chem. 40 1997 2117 2122
17. F. Labrie, C. Labrie, A. Bélanger, J. Simard, S. Gauthier, V. Luu-The, Y. Mérand, V. Giguère, B. Candas, S. Luo, C. Martel, S.M. Singh, M. Fournier, A. Coquet, V. Richard, R. Charbonneau, G. Charpenet, A. Tremblay, G. Tremblay, L. Cusan, and R. Veilleux EM-652 (SCH 57068): a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium J. Steroid Biochem. Mol. Biol. 69 1999 51 84
18. G.B. Tremblay, A. Tremblay, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, F. Labrie, and V. Giguere Cloning, chromosomal localization and functional analysis of the murine estrogen receptor β Mol. Endocrinol. 11 1997 353 365
19. S. Dauvois, C.S. Geng, C. Lévesque, Y. Mérand, and F. Labrie Additive inhibitory effects of an androgen and the antiestrogen EM-170 on estradiol-stimulated growth of human ZR-75-1 breast tumors in athymic mice Cancer Res. 51 1991 3131 3135
20. S. Couillard, C. Labrie, A. Bélanger, B. Candas, F. Pouliot, and F. Labrie Effect of dehydroepiandrosterone and the antiestrogen EM-800 on the growth of human ZR-75-1 breast cancer xenografts J. Natl. Cancer Inst. 90 1998 772 778
21. F. Labrie, M. El-Alfy, L. Berger, C. Labrie, C. Martel, A. Bélanger, B. Candas, and G. Pelletier The combination of a novel SERM with an estrogen protects the mammary gland and uterus in a rodent model: the future of postmenopausal women's health? Endocrinology 144 2003 4700 4706
22. W.M. van Weerden, H.G. Bierings, G.J. van Steenbrugge, F.H. de Jong, and F.H. Schroder Adrenal glands of mouse and rat do not synthesize androgens Life Sci. 50 1992 857 861
23. C.Y. Kramer Extension of multiple range tests to group means with unique numbers of replications Biometrics 12 1956 307 310
24. Y.D. Yuan, and G.L. Foley Female reproductive system M.A. Wallig Handbook of Toxicologic Pathology second ed. 2002 Elsevier Science USA
25. J.L. Ladinsky, H.W. Gruchow, and B.M. Peckham Cellular behaviour of the vaginal epithelium treated with testosterone propionate alone and in combination with diethylstilboestrol J. Endocrinol. 41 1968 161 169
26. P.K. Mehrotra, and J.N. Karkun Studies on physiology and biochemistry of female genital tract: response of cervix and vagina of albino rats to estrogen, progesterone and testosterone Indian J. Exp. Biol. 11 1973 1 6
27. M. Notelovitz Urogenital atrophy and low-dose vaginal estrogen therapy Menopause 7 2000 140 142
28. J.R. Berman, L.A. Berman, T.J. Werbin, and I. Goldstein Female sexual dysfunction: anatomy, physiology, evaluation and treatment options Curr. Opin. Urol. 9 1999 563 568
29. G.N. Papanicolaou, and E. Shorr The action of ovarian follicular hormones in the menopause, as indicated by vaginal smears Am. J. Obstet. Gynecol. 31 1936 806 831
30. M. Friedrich, D. Mink, C. Villena-Heinsen, A. Woll-Hermann, S. Wagner, and W. Schmidt The influence of tamoxifen on the maturation index of vaginal epithelium Clin. Exp. Obstet. Gynecol. 25 1998 121 124
31. B. Peckham, and W. Kiekhofer Cellular behavior in the vaginal epithelium of estrogen-treated rats Am. J. Obstet. Gynecol. 83 1962 1021 1027
32. H. Selye, J.S.L. Browne, and J.B. Collip Effect of combined administration of oestrone and progesterone in adult ovariectomized rats Proc. Soc. Exp. Biol. Med. 34 1936 198 200
33. S. Luo, A. Sourla, C. Labrie, S. Gauthier, Y. Merand, A. Belanger, and F. Labrie Effect of twenty-four-week treatment with the antiestrogen EM-800 on estrogen-sensitive parameters in intact and ovariectomized mice Endocrinology 139 1998 2645 2656
34. M.G. Sartori, M.J. Girao, M. de Jesus Simoes, J.P. Sartori, E.C. Baracat, and G. Rodrigues de Lima Quantitative evaluation of collagen and muscle fibers in the lower urinary tract of castrated and under-hormone replacement female rats Clin. Exp. Obstet. Gynecol. 28 2001 92 96
35. N. Fleischmann, G. Christ, T. Sclafani, and A. Melman The effect of ovariectomy and long-term estrogen replacement on bladder structure and function in the rat J. Urol. 168 2002 1265 1268
36. H.N. Yoon, W.S. Chung, Y.Y. Park, B.S. Shim, W.S. Han, and S.W. Kwon Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina Int. J. Impot. Res. 13 2001 205 211
37. S. Jackson, M. James, and P. Abrams The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence BJOG 109 2002 339 344
38. W.A. Anderson, and Y.H. Kang Estrogen and antagonist-induced structural changes in the cervico-vaginal epithelium of immature rats Am. J. Anat. 144 1975 197 207
39. M. Yoshida, K. Kudoh, S. Katsuda, M. Takahashi, J. Ando, and A. Maekawa Inhibitory effects of uterine endometrial carcinogenesis in Donryu rats by tamoxifen Cancer Lett. 134 1998 43 51
40. T.G. Kennedy, and D.T. Armstrong Induction of vaginal mucification in rats with testosterone and 17beta-hydroxy-5alpha-androstan-3-one Steroids 27 1976 423 430
41. A. Sourla, M. Flamand, A. Belanger, and F. Labrie Effect of dehydroepiandrosterone on vaginal and uterine histomorphology in the rat J. Steroid Biochem. Mol. Biol. 66 1998 137 149
42. A. Sourla, C. Martel, C. Labrie, and F. Labrie Almost exclusive androgenic action of dehydroepiandrosterone in the rat mammary gland Endocrinology 139 1998 753 764
43. A. Sourla, V. Richard, F. Labrie, and C. Labrie Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin J. Endocrinol. 166 2000 455 462
44. C. Martel, A. Sourla, G. Pelletier, C. Labrie, M. Fournier, S. Picard, S. Li, M. Stojanovic, and F. Labrie Predominant androgenic component in the stimulatory effect of dehydroepiandrosterone on bone mineral density in the rat J. Endocrinol. 157 1998 433 442
45. J.F. Knudsen, and V.B. Mahesh Initiation of precocious sexual maturation in the immature rat treated with dehydroepiandrosterone Endocrinology 97 1975 458 468
46. E.D. Lephart, D. Mathews, J.F. Noble, and S.R. Ojeda The vaginal epithelium of immature rats metabolizes androgens through an aromatase-like reaction: changes during the time of puberty Biol. Reprod. 40 1989 259 267
47. T.C. Shao, E. Castaneda, R.L. Rosenfield, and S. Liao Selective retention and formation of a delta5-androstenediol-receptor complex in cell nuclei of the rat vagina J. Biol. Chem. 250 1950 3095 3100
48. J. Poortman, J.A. Prenen, F. Schwarz, and J.H. Thijssen Interaction of delta-5-androstene-3beta, 17beta-diol with estradiol and dihydrotestosterone receptors in human myometrial and mammary cancer tissue J. Clin. Endocrinol. Metab. 40 1975 373 379
49. L.G. Van Doorn, J. Poortman, J.H. Thijssen, and F. Schwarz Actions and interactions of 5-androstene-3β, 17β-diol and estradiol 17β in the immature rat uterus Endocrinology 108 1981 1587 1593
50. J. Adams, M. Garcia, and H. Rochefort Estrogenic effects of physiological concentrations of 5-androstene-3 beta, 17 beta-diol and its metabolism in MCF7 human breast cancer cells Cancer Res. 41 1981 4720 4726
51. R. Poulin, and F. Labrie Stimulation of cell proliferation and estrogenic response by adrenal C19-delta 5-steroids in the ZR-75-1 human breast cancer cell line Cancer Res. 46 1986 4933 4937
52. C. Martel, S. Picard, V. Richard, A. Belanger, C. Labrie, and F. Labrie Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat J. Steroid Biochem. Mol. Biol. 74 2000 45 56
53. R. Munarriz, S.W. Kim, N.N. Kim, A. Traish, and I. Goldstein A review of the physiology and pharmacology of peripheral (vaginal and clitoral) female genital arousal in the animal model J. Urol. 170 2003 S40 S44 (discussion S44-S45)
54. T. Simoncini, G. Varone, L. Fornari, P. Mannella, M. Luisi, F. Labrie, and A.R. Genazzani Genomic and nongenomic mechanisms of nitric oxide synthesis induction in human endothelial cells by a fourth-generation selective estrogen receptor modulator Endocrinology 143 2002 2052 2061
55. T. Simoncini, P. Mannella, L. Fornari, G. Varone, A. Caruso, and A.R. Genazzani Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms Endocrinology 144 2003 3449 3455
56. A.T. Guay, and J. Jacobson Decreased free testosterone and dehydroepiandrosterone (DHEA-S) levels in women with decreased libido J. Sex Marit. Ther. 28 2002 129 142
57. H. Wang, H. Eriksson, and L. Sahlin Estrogen receptors alpha and beta in the female reproductive tract of the rat during the estrous cycle Biol. Reprod. 63 2000 1331 1340
58. M.D. Mergman, B.S. Schachter, K. Karelus, E.P. Combatsiaris, T. Garcia, and J.F. Nelson Up-regulation of the uterine estrogen receptor and its messager ribonucleic acid during the mouse estrous cycle: the role of estradiol Endocrinology 130 1992 1923 1930
59. M. Maggiolini, O. Donzé, E. Jeannin, S. Ando, and D. Picard Adrenal androgens stimulate the proliferation of breast cancer cells as direct activators of estrogen receptor a Cancer Res. 59 1999 4864 4869
60. L.A. Mattson, G. Culberg, O. Eriksson, and F. Kruitsson Vaginal administration of low dose estradiol: effects on endometrium and vaginal cytology Maturitas 1989 217 222
61. F. Labrie Extragonadal synthesis of sex steroids: intracrinology Ann. Endocrinol. (Paris) 64 2003 95 107
62. P. Popesko, V. Rajtova, and J. Horak Female reproductive organs - a colour atlas of anatomy of small laboratory animals, volume two: rat-mouse-hamster Elsevier Sci. 2003 85