Preparation of alginate gel beads containing chitosan nicotinic acid salt and the functions

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 48, Issue 1, 1999, Pages 49-52

  Murata, Y ^a   Toniwa, S ^a   Miyamoto, E ^a   Kawashima, S ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

Alginate gel; Bile acid; Chitosan nicotinic acid

Indexed keywords

ALGINIC ACID; BILE ACID; CALCIUM; CHITIN; CHITOSAN; CHITOSAN DERIVATIVE; CURDLAN; DEXTRAN SULFATE; GLYCOCHENODEOXYCHOLIC ACID; GLYCOCHOLIC ACID; HYDROCHLORIC ACID; NICOTINIC ACID; PULLULAN; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; XYLAN;

ARTICLE; CONTROLLED STUDY; DISSOLUTION; DRUG RELEASE; DRUG UPTAKE; GASTROINTESTINAL TRACT; GEL;

ALGINATES; ANTILIPEMIC AGENTS; BILE ACIDS AND SALTS; CALCIUM; CHITIN; CHITOSAN; MICROSPHERES; NIACIN; SOLUBILITY;

EID: 0032990866     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(99)00026-0     Document Type: Article

References (10)

1. Remunan-Lopez C., Portero A., Vila-Jato J.L., Alonso M.J. Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery. J. Control. Rel. 55:1998;143-152.
2. Munjeri O., Hodza P., Osim E., Musabayane C.T. An investigation into the suitability of amidated pectin hydrogel beads as a delivery matrix for chloroquine. J. Pharm. Sci. 87:1998;905-908.
3. Aral C., Akbuga J. Alternative approach to the preparation of chitosan beads. Int. J. Pharm. 168:1998;9-15.
4. Deuchi K., Kanamichi O., Imasato Y., Kobayashi E. Decreasing effect of chitosan on the apparent fat digestibility by rats fed on a high-fat diet. Biosci. Biotechnol. Biochem. 58:1994;1613-1616.
5. Kikuchi A., Kawabuchi M., Sugihara M., Sakurai Y., Okano T. Pulsed dextran release from calcium-alginate gel beads. J. Control. Release. 47:1997;21-29.
6. Gaserod O., Jolliffe I.G., Hampson F.C., Dettmar P.W., Skjak-Braek G. The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan. Int. J. Pharm. 175:1998;237-246.
7. Murata Y., Katayama N., Kajita T., Miyamoto E., Kawashima S. The fixation of a water-soluble drug in calcium-induced alginate gel beads and the release profiles from the vehicle. Drug Delivery System. 12:1997;49-55.
8. Murata Y., Toniwa S., Miyamoto E., Kawashima S. Preparation of alginate gel beads containing chitosan salt and their function. Int. J. Pharm. 1998;. in press.
9. Kramer W., Wess G., Enhsen A., Falk E., Hoffmann A., Neckermann G., Schubert G., Urmann M. Modified bile acids as carrier for peptides and drugs. J. Control. Release. 46:1997;17-30.
10. Murata Y., Miyamoto E., Kawashima S. Additive effect of chondroitin sulfate and chitosan on drug release from calcium-induced alginate gel beads. J. Control. Release. 38:1996;101-108.