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Volumn 65, Issue 15, 2005, Pages 6927-6933

Halogenated thymidine analogues restore the expression of silenced genes without demethylation

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BISULFITE; BROXURIDINE; CLOXURIDINE; DNA; GLUTATHIONE TRANSFERASE; HALIDE; HISTONE H3; IDOXURIDINE; LUCIFERASE; RETROVIRUS VECTOR; THYMIDINE DERIVATIVE; TRICHOSTATIN A;

EID: 23044516024     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3495     Document Type: Article
Times cited : (13)

References (39)
  • 1
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression-belts, braces, and chromatin
    • Bird AP, Wolffe AP. Methylation-induced repression-belts, braces, and chromatin. Cell 1999;99:451-4.
    • (1999) Cell , vol.99 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 2
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21:163-7.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 3
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SB, Herman JG. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000;16:168-74.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 4
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3: 415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 5
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004;429:457-63.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 6
    • 0742269866 scopus 로고    scopus 로고
    • Decitabine
    • Issa JP. Decitabine. Curr Opin Oncol 2003;15:446-51.
    • (2003) Curr Opin Oncol , vol.15 , pp. 446-451
    • Issa, J.P.1
  • 7
    • 0035169663 scopus 로고    scopus 로고
    • Methyl-CpG-binding proteins. Targeting specific gene repression
    • Ballestar E, Wolffe AP. Methyl-CpG-binding proteins. Targeting specific gene repression. Eur J Biochem 2001;268:1-6.
    • (2001) Eur J Biochem , vol.268 , pp. 1-6
    • Ballestar, E.1    Wolffe, A.P.2
  • 8
    • 13644255586 scopus 로고    scopus 로고
    • Antisense MBD2 gene therapy inhibits tumorigenesis
    • Slack A, Bovenzi V, Bigey P, et al. Antisense MBD2 gene therapy inhibits tumorigenesis. J Gene Med 2002; 4:381-9.
    • (2002) J Gene Med , vol.4 , pp. 381-389
    • Slack, A.1    Bovenzi, V.2    Bigey, P.3
  • 10
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman JK. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002;21:5483-95.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 11
    • 0037962005 scopus 로고    scopus 로고
    • Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
    • Kantaijian HM, O'Brien S, Cortes J, et al. Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia. Cancer 2003;98:522-8.
    • (2003) Cancer , vol.98 , pp. 522-528
    • Kantaijian, H.M.1    O'Brien, S.2    Cortes, J.3
  • 12
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors-state of the art
    • Goffin J, Eisenhauer E. DNA methyltransferase inhibitors-state of the art. Ann Oncol 2002;13: 1699-716.
    • (2002) Ann Oncol , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 13
    • 0033582720 scopus 로고    scopus 로고
    • Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone
    • Hurd PJ, Whitmarsh AJ, Baldwin GS, et al. Mechanism-based inhibition of C5-cytosine DNA methyltransferases by 2-H pyrimidinone. J Mol Biol 1999; 286:389-401.
    • (1999) J Mol Biol , vol.286 , pp. 389-401
    • Hurd, P.J.1    Whitmarsh, A.J.2    Baldwin, G.S.3
  • 14
    • 0037420191 scopus 로고    scopus 로고
    • Inhibition of DNA methylation and reactivation of silenced genes by zebularine
    • Cheng JC, Matsen CB, Gonzales FA, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst 2003;95:399-409.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 399-409
    • Cheng, J.C.1    Matsen, C.B.2    Gonzales, F.A.3
  • 15
    • 1642499364 scopus 로고    scopus 로고
    • Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells
    • Cheng JC, Weisenberger DJ, Gonzales FA, et al. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 2004;24:1270-8.
    • (2004) Mol Cell Biol , vol.24 , pp. 1270-1278
    • Cheng, J.C.1    Weisenberger, D.J.2    Gonzales, F.A.3
  • 16
    • 4344643781 scopus 로고    scopus 로고
    • Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro
    • Satou Y, Nosaka K, Koya Y, Yasunaga JI, Toyokuni S, Matsuoka M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 2004;18:1357-63.
    • (2004) Leukemia , vol.18 , pp. 1357-1363
    • Satou, Y.1    Nosaka, K.2    Koya, Y.3    Yasunaga, J.I.4    Toyokuni, S.5    Matsuoka, M.6
  • 17
    • 0000994406 scopus 로고
    • Analysis of combined drug effects: A new look at a very old problem
    • Chou TC, Talalay P. Analysis of combined drug effects: a new look at a very old problem. Trends Pharmacol Sci 1983;4:450-4.
    • (1983) Trends Pharmacol Sci , vol.4 , pp. 450-454
    • Chou, T.C.1    Talalay, P.2
  • 18
    • 0002658308 scopus 로고
    • Quantitation of synergism and antagonism of two or more drugs by computerized analysis
    • Chou TC, Rideout DC, editors. San Diego (CA): Academic Press
    • Chou J. Quantitation of synergism and antagonism of two or more drugs by computerized analysis. In: Chou TC, Rideout DC, editors. Synergism and antagonism in chemotherapy. San Diego (CA): Academic Press: 1991. p. 223-44.
    • (1991) Synergism and Antagonism in Chemotherapy , pp. 223-244
    • Chou, J.1
  • 19
    • 0034652785 scopus 로고    scopus 로고
    • Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia
    • Nosaka K, Maeda M, Tamiya S, Sakai T, Mitsuya H, Matsuoka M. Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia. Cancer Res 2000;60:1043-8.
    • (2000) Cancer Res , vol.60 , pp. 1043-1048
    • Nosaka, K.1    Maeda, M.2    Tamiya, S.3    Sakai, T.4    Mitsuya, H.5    Matsuoka, M.6
  • 20
    • 0033924544 scopus 로고    scopus 로고
    • Glutathione S-transferase enzyme expression in hematopoietic cell lines implies a differential protective role for T1 and A1 isoenzymes in erythroid and for M1 in lymphoid lineages
    • Wang L, Groves MJ, Hepburn MD, Bowen DT. Glutathione S-transferase enzyme expression in hematopoietic cell lines implies a differential protective role for T1 and A1 isoenzymes in erythroid and for M1 in lymphoid lineages. Haematologica 2000;85:573-9.
    • (2000) Haematologica , vol.85 , pp. 573-579
    • Wang, L.1    Groves, M.J.2    Hepburn, M.D.3    Bowen, D.T.4
  • 21
    • 0842307061 scopus 로고    scopus 로고
    • Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9
    • Mutskov V, Felsenfeld G, Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J 2004;23:138-49.
    • (2004) EMBO J , vol.23 , pp. 138-149
    • Mutskov, V.1    Felsenfeld, G.2
  • 22
    • 0035906936 scopus 로고    scopus 로고
    • Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA
    • Ohki I, Shimotake N, Fujita N, et al. Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell 2001; 105:487-97.
    • (2001) Cell , vol.105 , pp. 487-497
    • Ohki, I.1    Shimotake, N.2    Fujita, N.3
  • 23
    • 0037444026 scopus 로고    scopus 로고
    • The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties
    • Fraga MF, Ballestar E, Montoya G, Taysavang P, Wade PA, Esteller M. The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. Nucleic Acids Res 2003;31:1765-74.
    • (2003) Nucleic Acids Res , vol.31 , pp. 1765-1774
    • Fraga, M.F.1    Ballestar, E.2    Montoya, G.3    Taysavang, P.4    Wade, P.A.5    Esteller, M.6
  • 24
    • 2642553379 scopus 로고    scopus 로고
    • Sea urchin insulator protects lentiviral vector from silencing by maintaining active chromatin structure
    • Hino S, Fan J, Taguwa S, Akasaka K, Matsuoka M. Sea urchin insulator protects lentiviral vector from silencing by maintaining active chromatin structure. Gene Ther 2004;11:819-28.
    • (2004) Gene Ther , vol.11 , pp. 819-828
    • Hino, S.1    Fan, J.2    Taguwa, S.3    Akasaka, K.4    Matsuoka, M.5
  • 25
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
    • Yoshida M, Kijima M, Akita M, Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 1990;265:17174-9.
    • (1990) J Biol Chem , vol.265 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2    Akita, M.3    Beppu, T.4
  • 26
    • 0037439798 scopus 로고    scopus 로고
    • Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells
    • Lin X, Nelson WG. Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells. Cancer Res 2003;63:498-504.
    • (2003) Cancer Res , vol.63 , pp. 498-504
    • Lin, X.1    Nelson, W.G.2
  • 27
    • 0037154972 scopus 로고    scopus 로고
    • Epigenetic codes for heterochromatin formation and silencing: Rounding up the usual suspects
    • Richards EJ, Elgin SC. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 2002;108:489-500.
    • (2002) Cell , vol.108 , pp. 489-500
    • Richards, E.J.1    Elgin, S.C.2
  • 28
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X, Ng HH, Johnson CA, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998;393: 386-9.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3
  • 29
    • 0036574913 scopus 로고    scopus 로고
    • Unravelling heterochromatin: Competition between positive and negative factors regulates accessibility
    • Dillon N, Festenstein R. Unravelling heterochromatin: competition between positive and negative factors regulates accessibility. Trends Genet 2002;18:252-8.
    • (2002) Trends Genet , vol.18 , pp. 252-258
    • Dillon, N.1    Festenstein, R.2
  • 30
    • 0035883954 scopus 로고    scopus 로고
    • Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails
    • Zhang Y, Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 2001;15:2343-60.
    • (2001) Genes Dev , vol.15 , pp. 2343-2360
    • Zhang, Y.1    Reinberg, D.2
  • 31
    • 0037112369 scopus 로고    scopus 로고
    • Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′- deoxycytidine
    • Nguyen CT, Weisenberger DJ, Velicescu M, et al. Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine. Cancer Res 2002;62: 6456-61.
    • (2002) Cancer Res , vol.62 , pp. 6456-6461
    • Nguyen, C.T.1    Weisenberger, D.J.2    Velicescu, M.3
  • 32
    • 0034099348 scopus 로고    scopus 로고
    • Long-term silencing of retroviral vectors is resistant to reversal by trichostatin a and 5-azacytidine
    • McInerney JM, Nawrocki JR, Lowrey CH. Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine. Gene Ther 2000;7: 653-63.
    • (2000) Gene Ther , vol.7 , pp. 653-663
    • McInerney, J.M.1    Nawrocki, J.R.2    Lowrey, C.H.3
  • 33
    • 0017727698 scopus 로고
    • 5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine
    • Singer J, Stellwagen RH, Roberts-Ems J, Riggs AD. 5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine. J Biol Chem 1977;252: 5509-13.
    • (1977) J Biol Chem , vol.252 , pp. 5509-5513
    • Singer, J.1    Stellwagen, R.H.2    Roberts-Ems, J.3    Riggs, A.D.4
  • 34
    • 0020626342 scopus 로고
    • Transcriptional activation of endogenous rat retrovirus with and without hypomethylation of proviral DNA
    • Schwartz SA. Transcriptional activation of endogenous rat retrovirus with and without hypomethylation of proviral DNA. Biochem Biophys Res Commun 1983; 112:571-7.
    • (1983) Biochem Biophys Res Commun , vol.112 , pp. 571-577
    • Schwartz, S.A.1
  • 35
    • 0036345455 scopus 로고    scopus 로고
    • Gene silencing quantitatively controls the function of a developmental trans-activator
    • Hutchins AS, Mullen AC, Lee HW, et al. Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell 2002;10:81-91.
    • (2002) Mol Cell , vol.10 , pp. 81-91
    • Hutchins, A.S.1    Mullen, A.C.2    Lee, H.W.3
  • 36
    • 0037370035 scopus 로고    scopus 로고
    • MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters
    • Lembo F, Pero R, Angrisano T, et al. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. Mol Cell Biol 2003;23:1656-65.
    • (2003) Mol Cell Biol , vol.23 , pp. 1656-1665
    • Lembo, F.1    Pero, R.2    Angrisano, T.3
  • 37
    • 0034636551 scopus 로고    scopus 로고
    • Disruption of the plant gene MOM releases transcriptional silencing of methylated genes
    • Amedeo P, Habu Y, Afsar K, Scheid OM, Paszkowski J. Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Nature 2000;405: 203-6.
    • (2000) Nature , vol.405 , pp. 203-206
    • Amedeo, P.1    Habu, Y.2    Afsar, K.3    Scheid, O.M.4    Paszkowski, J.5
  • 38
    • 0019332244 scopus 로고
    • Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides
    • Fasy TM, Cullen BR, Luk D, Bick MD. Studies on the enhanced interaction of halodeoxyuridine-substituted DNAs with H1 histones and other polypeptides. J Biol Chem 1980;255:1380-7.
    • (1980) J Biol Chem , vol.255 , pp. 1380-1387
    • Fasy, T.M.1    Cullen, B.R.2    Luk, D.3    Bick, M.D.4
  • 39
    • 0022253927 scopus 로고
    • Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat
    • Graves BJ, Eisenman RN, McKnight SL. Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat. Mol Cell Biol 1985;5:1948-58.
    • (1985) Mol Cell Biol , vol.5 , pp. 1948-1958
    • Graves, B.J.1    Eisenman, R.N.2    McKnight, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.