Calpain activation and not oxidative damage mediates L-2- chloropropionic acid-induced cerebellar granule cell necrosis

Toxicology and Applied Pharmacology

Volumn 142, Issue 2, 1997, Pages 248-255

  Widdowson, P S ^a   Gyte, A ^a   Upton, R ^a   Foster, J ^a   Coutts, C T ^a   Wyatt, I ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROPROPIONIC ACID; 2 [[4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]METHYL] 3,4 DIHYDRO 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 6 OL; 21 [4 [2,6 BIS(1 PYRROLIDINYL) 4 PYRIMIDINYL] 1 PIPERAZINYL]PREGNA 1,4,9(11) TRIENE 3,20 DIONE; CALCIUM; CALPAIN; N METHYL DEXTRO ASPARTIC ACID; N TERT BUTYLPHENYLNITRONE; NORPHENAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM BINDING; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; GRANULE CELL; LIPID PEROXIDATION; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALIA; LETHRINIDAE;

EID: 0031062295     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.7940     Document Type: Article

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