Effects of aging on cytochrome B5 expression in the human adrenal gland

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 7, 2005, Pages 4357-4361

  Dharia, Sejal ^a   Slane, Audry ^a   Jian, Ming ^a   Conner, Michael ^b   Conley, Alan J ^c   Brissie, Robert M ^b   Parker Jr , C Richard ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B5; EOSIN; HEMATOXYLIN; PARAFFIN; STEROID 17,20 LYASE;

ADRENAL CORTEX; ADRENAL GLAND; ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; AUTOPSY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENDER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE DISPLAY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INJURY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RACE DIFFERENCE; STAINING; SUDDEN DEATH; UNIVERSITY HOSPITAL;

ADRENAL GLANDS; ADULT; AGED; AGED, 80 AND OVER; AGING; CYTOCHROMES B5; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED;

EID: 23044509470     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2005-0017     Document Type: Article

References (38)

1. Parker LN, Odell WD 1978 Decline of adrenal androgen production as measured by radioimmunoassay of urinary unconjugated dehydroepiandrosterone. J Clin Endocrinol Metab 47:600-602
2. Labrie F, Belanger A, Cusan L, Gomez JL, Candas B 1997 Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82:2396-2402
3. Laughlin GA, Barrett-Connor E 2000 Sexual dimorphism in the influence of advanced aging on adrenal hormone levels: the Rancho Bernardo Study. J Clin Endocrinol Metab 85:3561-3568
4. Meldrum DR, Davidson BJ, Tataryn IV, Judd HL 1981 Changes in circulating steroids with aging in postmenopausal women. Obstet Gynecol 57:624-628
5. Parker, CR 1999 Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids 64:640-647
6. Vermeulen A, Deslypere JP, Schelfhout W, Verdonck L, Rubens R 1987 Adrenocortical function in old age: response to acute adrenocorticotropin stimulation. J Clin Endocrinol Metab 54:187-191
7. Flood JF, Roberts E 1988 Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res 448:178-181
8. Notelovitz M 2002 Androgen effects on bone and muscle. Fertil Steril 77:S34-S41
9. Luo S, Labrie C, Belanger A, Labrie F 1997 Effect of dehydroepiandrosterone on bone mass, serum lipids, and dimethylbenz(a) anthracene-induced mammary carcinoma in the rat. Endocrinology 138:3387-3394
10. Bachmann GA 2002 The hypoandrogenic woman: pathophysiologic overview. Fertil Steril 77:S72-S76
11. Nakajin S, Shinoda M, Haniu M, Shively JE, Hall PF 1984 C21 steroid side-chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17α-hydroxylase/c17,20 lyase cytochrome P450. J Biol Chem 259:3971-3976
12. Miller WL, Auchus RJ, Geller DH 1997 The regulation of 17,20 lyase activity. Steroids 62:133-142
13. Parker Jr CR, Baxter CR 1985 Divergence in adrenal steroid secretory pattern after thermal injury in adult patients. J Trauma 25:508-510
14. Liu CH, Laughlin GA, Fischer UG, Yen SSC 1990 Marked attenuation of ultradian and circadian rhythms of dehydroepiandrosterone in postmenopausal women: evidence for a reduced 17,20-desmolase enzymatic activity. J Clin Endocrinol Metab 71:900-906
15. Cutler GB, Davis Jr SE, Jonsonbaugh RE, Loriaux DL 1979 Dissociation of cortisol and adrenal androgen secretion in patients with secondary adrenal insufficiency. J Clin Endocrinol Metab 49:604-609
16. Toscano V, Balducci R, Adamo MV, Mangiantini A, Cives C, Boscherini B 1989 Changes in steroid pattern following acute and chronic adrenocorticotropin administration in premature adrenarche. J Steroid Biochem 32:321-326
17. Parker LN, Levin ER, Lifrak ET 1985 Evidence for adrenocortical adaptation to severe illness. J Clin Endocrinol Metab 60:947-952
18. Kate-Booij MJ, Cobbaert C, Koper JW, de Jong FH 2004 Deficiency of 17,20-lyase causing giant ovarian cysts in a girl and a female phenotype in her 46, XY sister: case report. Hum Reprod 19:456-459
19. Fan YS, Sasi R, Lee C, Winter JSD, Waterman MR, Lin CC 1992 Localization of the human CYP17 gene (P450 17α to 10q24.3) by fluorescence in situ hybridization and simultaneous chromosome banding. Genomics 14:1110-1111
20. 106 and P450 reductase. Endocrinology 132:2498-2506
21. Auchus RJ, Lee TC, Miller WL 1998 Cytochrome b5 augments the 17,20-lyase activity of human p450c17 without direct electron transfer. J Biol Chem 273:3158-3165
22. Zhang L, Rodriguez H, Ohno S, Miller WL 1995 Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and for the polycystic ovary syndrome. Proc Natl Acad Sci USA 92:10619-10623
23. Katagiri M, Waterman MR 1995 The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Arch Biochem Biophys 317:343-347
24. Lee-Robichaud P, Wright JN, Akhtar ME, Akhtar M 1995 Modulation of the activity of human 17α hydroxylase-17,20 lyase (CYP17) by cytochrome b5: endocrinological and mechanistic implications. J Biochem 308:901-908
25. Dharia SP, Slane A, Jian M, Conner M, Conley AJ, Parker Jr CR 2004 Co-localization of P450c17 and cytochrome b5 in androgen synthesizing tissues of the human. Biol Reprod 71:83-88
26. Rainey WE, Carr BR, Sasano H, Suzuki T, Mason JI 2002 Dissecting human adrenal androgen production. Trends Endocrinol Metab 13:234-239
27. Suzuki T, Sasano H, Takeyama J, Kaneko C, Freije WA, Carr BR, Rainey WE 2000 Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf) 53:739-747
28. Endoh A, Kristiansen SB, Casson PR, Buster JE, Hornsby PJ 1996 The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3β-hydroxysteroid dehydrogenase. J Clin Endocrinol Metab 81:3558-3565
29. Parker Jr CR, Mixon RL. Brissie RM. Grizzle WE 1997 Aging alters zonation in the adrenal cortex of men. J Clin Endocrinol Metab 82:3898-3901
30. Mapes S, Corbin CJ, Tarantal A, Conley A 1999 The primate adrenal zona reticularis is defined by expression of cytochrome b5, 17α-hydroxylase/17, 20-lyase cytochrome P450 (P450c17) and NADPH-cytochrome P450 reductase (reductase) but not 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD). J Clin Endocrinol Metab 84:3382-3385
31. Kreiner VE, Dhom G 1979 Altersveranderungen der menschlichen Nebenniere. Zbl Allg Pathol U Pathol Anat 123:351-360
32. Schwartz AG, Pashko L, Whitcomb JM 1986 Inhibition of tumor development by dehydroepiandrosterone and related steroids. Toxicol Pathol 14:357-362
33. Parker LN, Lifrak ET, Mamadan MB, Lai MK 1983 Aging and the human zona reticularis. Arch Androl 10:17-20
34. Kennerson AR, McDonald DA, Adams JB 1983 Dehydroepiandrosterone sulfotransferase localization in human adrenal glands: a light and electron microscopic study. J Clin Endocrinol Metab 56:786-790
35. Parker Jr CR, Jian M, Conley AJ 2000 The localization of DHEA sulfotransferase in steroidogenic and steroid metabolizing tissues of the adult rhesus macaque monkey. Endocr Res 517-522
36. Connell, M, Mixon RL, Brissie RL, Parker Jr CR 1999 Aging effects on immunohistochemical localization of DHEA sulfotransferase in the adrenal cortex of women. J Soc Gynecol Invest 6 (Suppl):92A
37. Didenko VV, Wang X, Yang L, Hornsby P 1996 Expression of p21WAF1/CIP1/SDl1 and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. J Clin Invest 97:1723-1731
38. Yanase T, Sasano H, Yubisui T, Sakai Y, Takayanagi R, Nawata H 1998 Immunohistochemical study of cytochrome b5 in human adrenal gland and in adrenocortical adenomas from patients with Cushing's syndrome. Endocr J 45:89-95