Optimization of carotenoid production by Rhodotorula glutinis using statistical experimental design

World Journal of Microbiology and Biotechnology

Volumn 21, Issue 4, 2005, Pages 429-434

  Park, P K ^a   Cho, D H ^a   Kim, E Y ^a   Chu, K H ^b  

^a University of Seoul   (South Korea)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Carotenoids; Factorial design; Medium optimization; Rhodotorula glutinis

Indexed keywords

BIOMASS; FERMENTATION; MOLASSES; PH EFFECTS; POTASSIUM COMPOUNDS; STATISTICAL METHODS;

CAROTENOIDS; RHODOTORULA GLUTINIS; STATISTICAL EXPERIMENTATION DESIGN; SUGAR CANE MOLASSES (SCM);

PROTEINS;

RHODOTORULA GLUTINIS; SACCHARUM; SACCHARUM HYBRID CULTIVAR;

EID: 22944482142     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-004-1891-3     Document Type: Article

References (17)

1. P. Bhosale R.V. Gadre 2001 β-Carotene production in sugarcane molasses by a Rhodotorula glutinis mutant Journal of Industrial Microbiology and Biotechnology 26 327 332
2. P. Buzzini 2000 An optimization study of carotenoid production by Rhodotorula glutinis DBVPG 3853 from substrates containing concentrated rectified grape must as the sole carbohydrate source Journal of Industrial Microbiology and Biotechnology 24 41 45
3. P. Buzzini 2001 Batch and fed-batch carotenoid production by Rhodotorula glutinis Debaryomyces castellii co-cultures in corn syrup Journal of Applied Microbiology 90 843 847
4. J.A. Florencio C.R. Soccol L.F. Furlanetto T.M.B. Bonfim N. Krieger M. Baron J.D. Fontana 1998 A factorial approach for sugarcane juice-based low cost culture medium: increasing the astaxanthin production by the red yeast Phaffia rhodozyma Bioprocess Engineering 19 161 164
5. G. Frengova K. Simova K. Pavlova D. Beshkova D. Grigorova 1994 Formation of carotenoids by Rhodotorula glutinis in whey ultrafiltrate Biotechnology and Bioengineering 44 888 894
6. Y. Goksungur Y. Mantzouridou T. Roukas 2002 Optimization of the production of β-carotene from molasses by Blakeslea trispora: a statistical approach Journal of Chemical Technology and Biotechnology 77 933 943
7. P.D. Haaland 1989 Experimental Design in Biotechnology Dekker New York
8. M. Kennedy D. Krouse 1999 Strategies for improving fermentation medium performance: a review Journal of Industrial Microbiology and Biotechnology 23 456 475
9. E.Y. Kim P.K. Park H.J. Chae 1998 Optimization of culture conditions for extracellular lipid production from Rhodotorula glutinis K-501 Korean Journal of Biotechnology and Bioengineering 13 58 64
10. P.C. Lee C. Schmidt-Dannert 2002 Metabolic engineering towards biotechnological production of carotenoids in microorganisms Applied Microbiology and Biotechnology 60 1 11
11. G.L. Miller 1959 Use of dinitrosalicylic acid reagent for determination of reducing sugar Analytical Chemistry 31 426 429
12. R.H. Myers D.C. Montgomery 2002 Response Surface Methodology: Process and Product Optimization Using Designed Experiments John Wiley & Sons New York
13. P.K. Park E.Y. Kim 2002 Extraction method of carotenoids from Rhodotorula glutinis Korean Journal of Biotechnology and Bioengineering 17 44 48
14. S. Siva Kesava G.-H. An C.-H. Kim S.-K. Rhee E.-S. Choi 1998 An industrial medium for improved production of carotenoids from a mutant strain of Phaffia rhodozyma Bioprocess Engineering 19 165 170
15. D. Somashekar R. Joseph 2000 Inverse relationship between carotenoid and lipid formation in Rhodotorula gracilis according to the C/N ratio of the growth medium World Journal of Microbiology and Biotechnology 16 491 493
16. M. Vazquez A.M. Martin 1998 Optimization of Phaffia rhodozyma continuous culture through response surface methodology Biotechnology and Bioengineering 57 314 320
17. D. Weuster-Botz 2000 Experimental design for fermentation media development: statistical design or global random search? Journal of Bioscience and Bioengineering 90 473 473