The chemoresistance gene ABCG2 (MXR/BCRP1/ABCP1) is not expressed in melanomas but in single neuroendocrine carcinomas of the skin

Journal of Cutaneous Pathology

Volumn 32, Issue 7, 2005, Pages 467-473

  Deichmann, Martin ^a,c   Thome, Marianne ^a   Egner, Ursula ^a   Hartschuh, Wolfgang ^a   Kurzen, Hjalmar ^b  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA;

ABCG2 GENE; ARTICLE; CONTROLLED STUDY; DERMATOFIBROSARCOMA PROTUBERANS; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MANTEL HAENSZEL TEST; MELANOCYTIC NEVUS; MELANOMA; MERKEL CELL TUMOR; NEUROENDOCRINE TUMOR; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CARCINOMA; SKIN METASTASIS; VASCULAR ENDOTHELIUM;

ATP-BINDING CASSETTE TRANSPORTERS; CARCINOMA, MERKEL CELL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; MELANOMA; NEOPLASM PROTEINS; NEVUS, PIGMENTED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SKIN NEOPLASMS;

EID: 22844453027     PISSN: 03036987     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0303-6987.2005.00359.x     Document Type: Article

References (40)

1. Rigel DS, Frieman RJ, Kopf AW. The incidence of malignant melanoma in the United States, issues as we approach the 21st century. J Am Acad Dermatol 1996; 34: 839.
2. Douglas JG, Margolin K. The treatment of brain metastases from malignant melanoma. Semin Oncol 2002; 29: 518.
3. Sertoli MR, Queirolo P, Bajetta E, et al. Multi-institutional phase II randomized trial of integrated therapy with cisplatin, dacarbazine, vindesine, subcutaneous interleukin-2, interferon alpha2a and tamoxifen in metastatic melanoma. Melanoma Res 1999; 9: 503.
4. Helmbach H, Rossmann E, Kern MAA, Schadendorf D. Drug resistance in human melanoma. Int J Cancer 2001; 93: 617.
5. Goldstein LJ, Galski H, Fojo A, et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989; 81: 116.
6. Levine EA, Holzmayer TA, Roninson IB, Gupta TKD. MDR-1 expression in metastatic malignant melanoma. J Surg Res 1993; 54: 621.
7. Fuchs B, Ostmeier H, Suter L. P-glycoprotein expression in malignant melanoma. J Cancer Res Clin Oncol 1991; 117: 168.
8. Schadendorf D, Makki A, Stahr C, et al. Membrane transport proteins associated with drug resistance expressed in human melanoma. Am J Pathol 1995; 147: 1545.
9. Benathan M, Alvero Jackson H, Mooy AM, et al. Relationship between melanogenesis, glutathione levels and melphalan toxicity in human melanoma cells. Melanoma Res 1992; 2: 305.
10. Schadendorf D, Jurgovsky K, Kohlmus CM, Czarnetzki BM. Glutathione and related enzymes in tumor progression and metastases of human melanoma. J Invest Dermatol 1995; 105: 109.
11. Ramachandran C, Samy TS, Huang XL, et al. Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells. Biochem Pharmacol 1993; 45: 1367.
12. Miyake K, Mickley L, Litman T, et al. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells, demonstration of homology to ABC transport genes. Cancer Res 1999; 59: 8.
13. Doyle LA, Yang W, Abruzzo LV, et al. A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc Natl Acad Sci USA 1998; 95: 15665.
14. Allen JD, Brinkhuis RF, Wijnholds J, Schinkel AH. The mouse Bcrp/Mxr/Abcp gene, amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin. Cancer Res 1999; 59: 4237.
15. Vortmeyer AO, Merino MJ, Boni R, et al. Genetic changes associated with primary Merkel cell carcinoma. Am J Clin Pathol 1998; 109: 565.
16. Poulsen M, Rischin D, Walpole E, et al. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation, a Trans-Tasman Radiation Oncology Group Study-TROG 96:07. J Clin Oncol 2003; 21:4371.
17. Endege WO, Steinmann KE, Boardman LA, et al. Represent ative cDNA libraries and their utility in gene expression profiling. Biotechniques 1999; 26: 542.
18. Zhou S, Schuetz JD, Bunting KD, et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001; 7: 1028.
19. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719.
20. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. J Histochem Cytochem 1981; 29: 577.
21. Hsu SM, Soban E. Color modification of diaminobenzidine (DAB) precipitation by metallic ions and its application for double immunohistochemistry. J Histochem Cytochem 1982; 30: 1079.
22. Diestra JE, Scheffer GL, Català I, et al. Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material. J Pathol 2002; 198: 213.
23. Maliepaard M, Scheffer GL, Faneyte IF, et al. Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res 2001; 61: 3458.
24. Rocchi E, Khodjakov A, Volk EL, et al. The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun 2000; 271: 42.
25. Allikmets R, Schriml LM, Hutchinson A, et al. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res 1998; 58: 5337.
26. Maliepaard M, van Gastelen MA, de Jong LA, et al. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res 1999; 59: 4559.
27. Ross DD, Yang W, Abruzzo LV, et al. Atypical multidrug resistance, breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. J Natl Cancer Inst 1999; 91: 429.
28. Lee JS, Scala S, Matsumoto Y, et al. Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression. J Cell Biochem 1997; 65: 513.
29. Leonard GD, Fojo T, Bates SE. The role of ABC transporters in clinical practice. Oncologist 2003; 8: 411.
30. Litman T, Druley TE, Stein WD, Bates SE. From MDR to MXR, new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci 2001; 58: 931.
31. Scheffer GL, Maliepaard M, Pijnenborg LM, et al. Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines. Cancer Res 2000; 60: 2589.
32. Bailey-Dell KJ, Hassel B, Doyle LA, Ross DD. Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene. Biochim Biophys Acta 2001; 1520: 234.
33. Jonker JW, Smit JW, Brinkhuis RF, et al. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst 2000; 92: 1651.
34. Kim M, Turnquist H, Jackson J, et al. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res 2002; 8: 22.
35. Scharenberg CW, Harkey MA, Torok-Storb B. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. Blood 2002; 99: 507.
36. Bunting KD. ABC transporters as phenotypic markers and functional regulators of stem cells. Stem Cells 2002; 20: 11.
37. Goodell MA, Jackson KA, Majka SM, et al. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci 2001; 938: 208.
38. Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA 1999; 96: 14482.
39. Lechner A, Leech CA, Abraham EJ, et al. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem Biophys Res Commun 2002; 293: 670.
40. Terunuma A, Jackson KL, Kapoor V, et al. Side population keratinocytes resembling bone marrow side population stem cells are distinct from label-retaining keratinocyte stem cells. J Invest Dermatol 2003; 121: 1095.