Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma

Pathology and Oncology Research

Volumn 11, Issue 2, 2005, Pages 92-97

  Simsa, Peter ^a   Teillaud, Jean Luc ^b   Stott, David I ^c   Tóth, József ^d   Kotlan, Beatrix ^a  

^a NATIONAL MEDICAL CENTER   (Hungary)

^b INSERM   (France)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Breast ductal carcinoma; Immunoglobulin variable region; Tumor infiltrating lymphocytes

Indexed keywords

B LYMPHOCYTE ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE ACTIVATION; BREAST CARCINOMA; CONTROLLED STUDY; FEMALE; GENE AMPLIFICATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; MOLECULAR CLONING; MULTIGENE FAMILY; PHENOTYPE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY;

EID: 22844448548     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02893374     Document Type: Article

References (31)

1. Madden JW: The immunology and immunotherapy of breast cancer: an update. Int J Immunopharmacol 21: 79-101, 1999
2. Ben-Hur H, Cohen O, Schneider D, et al: The role of lymphocytes and macrophages in human breast tumorigenesis: an immunohistochemical and morphometric study. Anticancer Res 22: 1231-1238, 2002
3. Di Girolamo V,Lauens RP, Coronato S, et al: Quantitative and functional study of breast cancer axillary lymph nodes and those draining other malignant tumors. J Exp Clin Cancer Res 19:155-159, 2000
4. Allan CP, Turtle CJ, Mainwaring PN, et al: The immune response to breast cancer, and the case for DC immunotherapy. Cytotherapy 6:154-163, 2004
5. Balch CM, Riley LB, Bae YJ, et al: Patterns of human tumor-infiltrating lymphocytes in 120 human cancers. Arch Surg 125:200-205, 1990
6. Schwartzentruber DJ, Solomon D, Rosenberg SA, et al: Characterization of lymphocytes infiltrating human breast cancer: specific immune reactivity detected by measuring cytokine secretion. J Immunother 12:1-12, 1992
7. Lin E, Pollard JW: Role of infiltrated leucocytes in tumour growth and spread. Br J Cancer 90:2053-8, 2004
8. Ladányi A: Function and prognostic significance of immune cells infiltrating human tumors. (In Hungarian) Magy Onkol 48:49-56, 2004
9. Filaci G, Fravegy M, Fenoglio D, et al: Non-antigen specific CD8+ T suppressor lymphocytes. Clin Exp Med 4:86-92, 2004
10. Whitford P, Mallon EA, George WD, et al: Flow cytometric analysis of tumor infiltrating lymphocytes in breast cancer. Br J Cancer 62:971-975, 1990
11. Lee RS, Schlumberger M, Caillou B, et al: Phenotypic and functional characterisation of tumor-infiltrating lymphocytes. Eur J Cancer 32: 1233-1239, 1996
12. Chin Y, Janssens J, Bleus J, et al: Characterization of tumor infiltrating lymphocytes in human breast cancer. Eur J Cancer Prev 2 (Suppl.33): 27-31, 1993
13. Grekou AN, Toliou T, Stravoravdi P, et al: Correlation of apoptosis with the distribution and composition of lymphocytic infiltrate in human breast carcinomas. Anticancer Res 16:3991-3995, 1996
14. Ridolfi RL, Rosen PP, Port A, et al: Medullary carcinoma of the breast. A clinicopathology study with 10 year follow-up. Cancer 40:1365-1385, 1977
15. Coronella JA, Spier C, Welch M, et al: Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast. J Immunol 169:1829-1836, 2002
16. Nzula S, Going JJ, Stott DI: Antigen driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas. Cancer Res 63: 3275-3280, 2003
17. Moore OS, Foots FW: The relatively favourable prognosis of medullary carcinoma of the breast. Cancer 2: 635-640, 1949
18. Marks JD, Tristem M, Karpas A, et al: Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific Oligonucleotide probes. Eur J Immunol 21:985-991, 1991
19. Sims GP, Shiono H, Willcox N, et al: Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. J Immunol 167:1935-1944, 2001
20. Tomlinson IM, Williams SC, Ignatovich O, et al: Human VBASE directory of immunoglobulin genes. Cambridge, UK: MRC Centre for Protein Engineering, 1997
21. Kotlan B, Gruel N, Zafrani B, et al: Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. Immunol Lett 65:143-151, 1999
22. Cuisinier AM, Guigou y Boubli, et al: Preferential expression of VH5 and VH6 immunoglobulin genes in early human B-cell ontogeny. Scand J Immunol 30: 493-497, 1989
23. Kotlan B, Simsa P, Foldi J, et al: Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. Human Antibodies 12: 113-121, 2003
24. Ito T, Saga S, Nagayoshi S, et al: Class distribution of immunoglobulin-containing plasma cells in the stroma of medullary carcinoma of breast. Breast Cancer Res Treat 7:97-103, 1986
25. Lazzaro B, Anderson AE, Kajdacsy-Balla A, et al: Antigenic characterization of medullary carcinoma of the breast: HLA-DR expression in lymph node positive cases. Appl Immunohistochem Mol Morphol 9: 234-241, 2001
26. Gaffey MJ, Frierson HF, Mills SE, et al: Medullary carcinoma of the breast: identification of lymphocyte subpopulations and their significance. Mod Pathol 6:721-728, 1993
27. Berek C, Berger A, Apel M: Maturation of the immune response in germinal centers. Cell 67:1121-1129, 1991
28. O'Brien PM, Tsirimonaki E, Coomber DW, et al: Immunoglobulin genes expressed by B-lymphocytes infiltrating cervical carcinomas show evidence of antigen-driven selection. Cancer Immunol Immunother 50:523-532, 2001
29. Friedman DF, Kraj P, Silber stein LE: VH4.21 Expression in the normal human B-cell repertoire. In: Immunoglobulin Gene Expression in Development and Disease. (Eds: Casali P, Silberstein LE) Ann New York Acad Sc 764:264-274, 1995
30. Stollar BD: The expressed heavy chain V gene repertoire of circulating B cells in normal adults. In: Immunoglobulin Gene Expression in Development and Disease. (Eds: Casali P, Silberstein LE) Ann New York Acad Sc 764:264-274, 1995
31. Kotlan B, Simsa P, Teillaud JL et al: Novel ganglioside antigen identified by B cells in human medullary breast carcinomas. The proof of principle concerning the infiltrating B lymphocytes. J Immun, 2005 (in press)