Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease

Kidney International

Volumn 55, Issue 3, 1999, Pages 936-944

  Hellmark, Thomas ^a   Segelmark, Mårten ^b   Unger, Christine ^b   Burkhardt, Harald ^b   Saus, Juan ^b   Wieslander, Jörgen ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

Autoantibody; B cell; Epitope; Glomerular basement membrane; Rapidly progressive glomerulonephritis

Indexed keywords

AUTOANTIBODY; COLLAGEN TYPE 4; EPITOPE;

AMINO TERMINAL SEQUENCE; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; GLOMERULUS BASEMENT MEMBRANE; GOODPASTURE SYNDROME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; TREATMENT OUTCOME;

EID: 0033050862     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.055003936.x     Document Type: Article

References (27)

1. Wieslander J, Bygren P, Heinegard D: Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. Proc Natl Acad Sci USA 81:1544-1548, 1984
2. Butkowski RJ, Langeveld JP, Wieslander J, Hamilton J, Hudson BG: Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 262:7874-7877, 1987
3. Hudson BG, Reeders ST, Tryggvason K: Type IV collagen: Structure, gene organization, and role in human disease. J Biol Chem 268:26033-26036, 1993
4. Timpl R, Oberbaumer I, Von Der Mark H, Bode W, Wick G, Weber S, Engel J: Structure and biology of the globular domain of basement membrane type IV collagen. Ann NY Acad Sci 460:58-72, 1985
5. Kleppel MM, Santi PA, Cameron JD, Wieslander J, Michael AF: Human tissue distribution of novel basement membrane collagen. Am J Pathol 134:813-825, 1989
6. Wieslander J, Langeveld J, Butkowski R, Jodlowski M, Noelken M, Hudson BG: Physical and immunochemical studies of the globular domain of type IV collagen: Cryptic properties Goodpasture antigen. J Biol Chem 260:8564-8570, 1985
7. Hellmark T, Johansson C, Wieslander J: Characterization of anti-GBM antibodies involved in Goodpastures syndrome. Kidney Int 46:823-829, 1994
8. Segelmark M, Butkowski R, Wieslander J: Antigen restriction and IgG subclasses among anti-GBM autoantibodies. Nephrol Dial Transplant 5:991-996, 1990
9. Neilson EG, Kalluri R, Sun MJ, Gunwar S, Danoff T, Mariyama M, Maers JC, Reeders ST, Hudson BG: Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen. J Biol Chem 268:8402-8405, 1993
10. Kefalides NA, Ohno N, Wilson CB: Heterogeneity of antibodies in Goodpasture syndrome reacting with type IV collagen. Kidney Int 43:85-93, 1993
11. Kalluri R, Gunwar S, Reeders ST, Morrison KC, Mariyama M, Ebner KE, Noelken ME, Hudson BG: Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the a3(IV) chain of basement membrane collagen. J Biol Chem 266:24018-24024, 1991
12. Hellmark T, Brunmark C, Trojnar J, Wieslander J: Epitope mapping of anti-glomerular basement membrane (GBM) antibodies with synthetic peptides. Clin Exp Immunol 105:504-510, 1996
13. Levy JB, Coulthart A, Pusey CD: Mapping of B cell epitopes in Goodpastures disease. J Am Soc Nephrol 8:1698-1705, 1997
14. Kalluri R, Sun MJ, Hudson BG, Neilson EG: The Goodpasture autoantigen: Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen. J Biol Chem 271:9062-9068, 1996
15. Quinones S, Bernal D, Garcia-Sogo M, Elena SF, Saus J: Exon/intron structure of the human alpha 3(IV) gene encompassing the Goodpasture antigen (alpha3(IV) NCl): Identification of a potentially antigenic region at the triple helix/NC1 domain junction. J Biol Chem 267:19780-19784, 1992
16. Penades JR, Bernal D, Revert F, Johansson C, Fresquet VJ, Cervera J, Wieslander J, Quinones S, Saus J: Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region: Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms. Eur J Biochem 229:754-760, 1995
17. Turner N, Ryan J, Phelps R, Rees AJ: B-cell epitopes of the Goodpasture antigen. (abstract) J Am Soc Nephrol 6:856, 1995
18. Netzer K-O, Gunwar S, Boutaud A, Leinonen A, Hudson BG: Identification of the Goodpasture epitope by analysis of chimeric alpha1/3(IV) molecules. (abstract) J Am Soc Nephrol 8:462A, 1997
19. Pusey CD, Dash A, Kershaw MJ, Morgan A, Reilly A, Rees AJ, Lockwood CMA: A single autoantigen in Goodpasture's syndrome identified by a monoclonal antibody to human glomerular basement membrane. Lab Invest 56:23-31, 1987
20. Johansson C, Butkowski R, Swedenborg P, Alm P, Wieslander J: Characterization of a non-Goodpasture autoantibody to type IV collagen. Nephrol Dial Transplant 8:1205-1210, 1993
21. Kalluri R, Petrides S, Wilson CB, Tomaszewski JE, Palevsky HI, Grippi MA, Madaio MP, Neilson EG: Anti-Alphal(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. Ann Intern Med 124:651-653, 1996
22. Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, Von Der Mark K: Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies. Matrix Biol 15:231-238, 1996
23. Schulte S, Unger C, Mo JA, Wendler O, Bauer E, Frischholz S, Von Der Mark K, Kalden JR, Holmdahl R, Bukkhardt H: Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils. J Biol Chem 273:1551-1561, 1998
24. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
25. Burnette WN: "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem 112:195-203, 1981
26. Johansson C, Butkowski R, Wieslander J: The structural organization of type IV collagen: Identification of three NC1 populations in the glomerular basement membrane. J Biol Chem 267:24533-24537, 1992
27. Revert F, Penedes JR, Plana M, Bernal D, Johansson C, Itarte E, Cervera J, Wieslander J, Quinones S, Suas J: Phosphorylation of the Goodpasture antigen by type A protein kinases. J Biol Chem 270:13254-13261, 1995