Hydrophobic amino acid residues are critical for the immunodominant epitope of the goodpasture autoantigen: A molecular basis for the cryptic nature of the epitope

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6370-6377

  David, Michelle ^a   Borza, Dorin Bogdan ^a   Leinonen, Anu ^a   Belmont, John M ^a   Hudson, Billy G ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COLLAGEN; DISEASES; IMMUNOLOGY; MONOCLONAL ANTIBODIES; MUTAGENESIS; TISSUE;

PATHOGENESIS;

ANTIGENS;

AUTOANTIGEN; COLLAGEN TYPE 4; EPITOPE; MONOCLONAL ANTIBODY; AUTOANTIBODY; COLLAGEN; TYPE IV COLLAGEN ALPHA3 CHAIN;

AMINO ACID METABOLISM; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CHIMERA; CONFORMATIONAL TRANSITION; GLOMERULONEPHRITIS; GLOMERULUS BASEMENT MEMBRANE; GOODPASTURE SYNDROME; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOREACTIVITY; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; TRIPLE HELIX; AMINO ACID SEQUENCE; CHEMISTRY; IMMUNOLOGY; MOLECULAR GENETICS; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

GLOMERULUS;

AMINO ACID SEQUENCE; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; AUTOANTIBODIES; AUTOANTIGENS; COLLAGEN; COLLAGEN TYPE IV; HUMANS; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035794146     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008956200     Document Type: Article

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