β2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals

American Journal of Hypertension

Volumn 18, Issue 7, 2005, Pages 1009-1014

  Masuo, Kazuko ^a,b   Katsuya, Tomohiro ^b   Fu, Yuxiao ^b   Rakugi, Hiromi ^b   Ogihara, Toshio ^b   Tuck, Michael L ^c  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 and 3 adrenoceptor polymorphisms; Blood pressure; Insulin resistance; Obesity; Sympathetic nerve activity

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; GLUCOSE; INSULIN; LEPTIN; MOLECULAR MARKER; NORADRENALIN; BIOLOGICAL MARKER; HORMONE;

ADULT; ALLELE; ANALYTICAL PARAMETERS; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; BODY FAT; BODY MASS; CONTROLLED STUDY; GENE FREQUENCY; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HEMOSTASIS; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; JAPAN; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; SYMPATHETIC TONE; ADRENERGIC SYSTEM; BLOOD; BODY COMPOSITION; GENE EXPRESSION PROFILING; GENETICS; HEART RATE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; GENE EXPRESSION PROFILING; GENOTYPE; HEART RATE; HOMEOSTASIS; HORMONES; HUMANS; INSULIN RESISTANCE; JAPAN; MALE; METABOLIC DISEASES; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, ADRENERGIC, BETA-3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYMPATHETIC NERVOUS SYSTEM;

EID: 22844435290     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2005.01.006     Document Type: Article

References (30)

1. M.L. Tuck Glucose, insulin, and insulin resistance as biomedical predictors of hypertension Am J Hypertens 4 1991 638S 641S
2. J.R. Sowers Obesity as a cardiovascular risk factor Am J Med 115 Suppl 8A 2003 37S 41S
3. D.B. Corry, M.L. Tuck Glucose and insulin metabolism in hypertension Am J Nephrol 16 1996 223 236
4. J. Cui, J.L. Hopper, S.B. Harrap Genes and family environment explain correlations between blood pressure and body mass index Hypertension 40 2002 7 12
5. R.G. Dluhy Screening for genetic causes of hypertension Curr Hypertens Rep 4 2002 439 444
6. 2 Adrenoceptor functional gene variants, obesity, and blood pressure level interactions in the general population Hypertension 42 2003 685 692
7. V. Large, L. Hellstrom, S. Reynisdottir, F. Lonnqvist, P. Eriksson, L. Lannfelt, P. Arner Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function J Clin Invest 100 1997 3005 3012
8. 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity N Engl J Med 333 1995 352 354
9. 3-adrenergic receptor gene and responses to treatment of obesity Lancet 346 1995 1433 1434
10. P. Strazzullo, R. Iacone, A. Siani, F.P. Cappuccio, O. Russo, G. Barba, A. Barbato, L. D'Elia, M. Trevisan, E. Farinaro Relationship of the Trp64Arg polymorphism of the beta3-adrenoceptor gene to central adiposity and high blood pressure interaction with age. Cross-sectional and longitudinal findings in the Olivetti Prospective Heart Study J Hypertens 19 2001 399 406
11. 3- adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects Biochem Biophys Res Commun 215 1995 555 560
12. 3-adrenergic-receptor gene N Engl J Med 333 1995 343 347
13. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Prevalence of hyperinsulinemia in young, nonobese, Japanese men J Hypertens 15 1997 157 165
14. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Sympathetic nerve hyperactivity precedes hyperinsulinemia and blood pressure elevation in a young, nonobese Japanese population Am J Hypertens 10 1997 77 83
15. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Weight gain-induced blood pressure elevation Hypertension 35 2000 1135 1140
16. K. Masuo, H. Kawaguchi, H. Mikami, T. Ogihara, M.L. Tuck Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation Hypertension 42 2003 474 480
17. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Familial hypertension, insulin, sympathetic activity, and blood pressure elevation Hypertension 32 1998 96 100
18. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Familial obesity, sympathetic activation and blood pressure level Blood Press 10 2001 199 204
19. K. Masuo, H. Mikami, T. Ogihara, M.L. Tuck Weight reduction and pharmacological treatment in obesity hypertensives Am J Hypertens 14 2001 530 538
20. M. Kanauchi, S. Yamano, K. Kanauchi, Y. Saito Homeostasis model assessment of insulin resistance, quantitive insulin sensitivity check index, and oral glucose insulin sensitivity index in nonobese, nondiabetic subjects with high-normal blood pressure J Clin Endocrinol Metab 88 2003 3444 3446
21. K. Ranade, M.S. Chang, C.T. Ting, D. Pei, C.F. Hsiao, M. Olivier, R. Pesich, J. Hebert, Y.D. Chen, V.J. Dzau, D. Curb, R. Olshen, N. Risch, D.R. Cox, D. Botstein High-throughput genotyping with single nucleotide polymorphisms Genome Res 11 2001 1262 1268
22. M.L. Tuck The sympathetic nervous system in essential hypertension Am Heart J 112 1988 877 886
23. G. Grassi, M. Esler How to assess sympathetic activity in humans J Hypertens 17 1999 719 734
24. K.H. Rahn, M. Barenbrock, M. Hausberg The sympathetic nervous system in the pathogenesis of hypertension J Hypertens 17 Suppl 3 1999 S11 S14
25. I.J. Kopin, B. Rundqvist, P. Friberg, J. Lenders, D.S. Goldstein, G. Eisenhofer Different relationships of spillover to release of norepinephrine in human heart, kidney, and forearm Am J Physiol 27 1998 R165 R173
26. 2-adrenoceptor gene polymorphism on obesity in males and in females J Intern Med 245 1999 253 259
27. 3 adrenergic receptor gene on weight gain in morbid obesity Diabetes Metab 23 1997 424 427
28. 2-adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians Hypertension 33 1999 1425 1430
29. T. Ikarashi, O. Hanyu, S. Maruyama, S. Souda, C. Kobayashi, E. Abe, J. Ukisu, K. Naganuma, A. Suzuki, M. Toya, S. Kaneko, K. Suzuki, O. Nakagawa, Y. Aizawa Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose in type 2 diabetic patients Diabetes Res Clin Pract 63 2004 11 18
30. T. Kawamura, G. Egusa, R. Fujikawa, M. Okubo Gln27Glu variant of the beta2-adrenergic receptor gene is not associated with obesity and diabetes in Japanese-Americans Metabolism 50 2001 443 446