Prodrug activation gated by a molecular "OR" logic trigger

Angewandte Chemie - International Edition

Volumn 44, Issue 28, 2005, Pages 4378-4381

  Amir, Roey J ^a   Popkov, Mikhail ^b   Lerner, Richard A ^b   Barbas III, Carlos F ^b   Shabat, Doron ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Catalytic antibodies; Drug delivery; Enzymes; Logic gates; Prodrugs

Indexed keywords

DRUG PRODUCTS; ENZYMES; LOGIC GATES; MOLECULES; SUBSTRATES;

FUNCTIONAL GROUPS; LINKERS; LOGIC TRIGGERS; PRODRUG ACTIVATION;

CHEMICAL ACTIVATION;

ANTIBODY ALDOLASE; ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; FRUCTOSE BISPHOSPHATE ALDOLASE; IMMUNOGLOBULIN F(AB) FRAGMENT; PENICILLIN AMIDASE; PRODRUG;

ARTICLE; BIOLOGICAL MODEL; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LOGIC; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; FRUCTOSE-BISPHOSPHATE ALDOLASE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; LOGIC; MODELS, BIOLOGICAL; PENICILLIN AMIDASE; PRODRUGS;

EID: 22744455193     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500842     Document Type: Article

References (19)

1. A. P. de Silva, N. D. McClenaghan, J. Am. Chem. Soc, 2000, 122, 3965.
2. A. P. de Silva, N. D. McClenaghan, Chem. Eur. J. 2004, 10, 574.
3. K. L. Kompa, R. D. Levine, Proc. Natl. Acad. Sci. USA 2001, 98, 410.
4. S. Sivan, S. Tuchman, N. Lotan, Biosystems 2003, 70, 21.
5. S. Uchiyama, N. Kawai, A. P. de Silva, K. Iwai, J. Am. Chem. Soc. 2004, 126, 3032.
6. J. M. Montenegro, E. Perez-Inestrosa, D. Collado, Y. Vida, R. Suau, Org. Lett. 2004, 6, 2353.
7. S. Giordani, F. M. Raymo, Org. Lett. 2003, 5, 3559.
8. K. Haba, M. Popkov, M. Shamis, R. A. Lerner, C. F. Barbas, 3rd, D. Shabat, Angew. Chem. 2005, 117, 726;
9. Angew. Chem. Int. Ed. 2005, 44, 716.
10. M. Shamis, H. N. Lode, D. Shabat, J. Am. Chem. Soc. 2004, 126, 1726.
11. F. M. de Groot, E. W. Damen, H. W. Scheeren, Curr. Med. Chem. 2001, 8, 1093.
12. L. Devy, F. M. de Groot, S. Blacher, A. Hajitou, P. H. Beusker, H. W. Scheeren, J. M. Foidart, A. Noel, FASEB J. 2004, 18, 565.
13. G. McSkimming, J. H. R. Tucker, H. Bouas-Laurent, J.-P. Desvergne, Angew. Chem. 2000, 112, 2251;
14. Angew. Chem. Int. Ed. 2000, 39, 2167.
15. R. J. Amir, D. Shabat, Chem. Commun. 2004, 1614.
16. G. S. Bignami, P. D. Senter, P. G. Grothaus, K. J. Fischer, T. Humphreys, P. M. Wallace, Cancer Res. 1992, 52, 5759.
17. D. Shabat, H. N. Lode, U. Pertl, R. A. Reisfeld, C. Rader, R. A. Lerner, C. F. Barbas III, Proc. Natl. Acad. Sci. USA 2001, 98, 7528.
18. D. Shabat, C. Rader, B. List, R. A. Lerner, C. F. Barbas III, Proc. Nat. Acad. SciUSA 1999, 96, 6925.
19. J. Wagner, R. A. Lerner, C. F. Barbas III, Science 1995, 270, 1797.