Iterative approach to the discovery of novel degarelix analogues: Substitutions at positions 3, 7, and 8. Part II

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4851-4860

  Samant, Manoj P ^a   Gulyas, Jozsef ^a   Hong, Doley J ^b   Croston, Glenn ^b   Rivier, Catherine ^a   Rivier, Jean ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Ferring Pharmaceuticals AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AZALINE B; CARRIER PROTEIN; DEGARELIX; DEGARELIX 3 [BETA N (2 PYRIDYLMETHYL) 3 DEXTRO ALPHA,BETA DIAMINOPROPIONIC ACID]; DEGARELIX 7 [7 PROPARGYLGLYCINE]; DEGARELIX 8 [SIGMA N (ISOPROPYLGLYCINE) 8 ORNITHINE]; DEGARELIX[BETA N (ISOPROPYL BETA ALANINE) 8 DEXTRO ALPHA,BETA DIAMINOPROPIONIC ACID]; DEGARELIX[GAMMA N (ISOPROPYLGLYCINE) 8 ALPHA,GAMMA DIAMINOBUTYRIC ACID]; DEGARELIX[NALPHA METHYL 7 LEUCINE]; DEGARELIX[NEPSILON CYCLOHEXYL 8 LYSINE]; DEGARELIX[SIGMA N ISOPROPYL 8 ORNITHINE]; FE 200486; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; HORMONE ANTAGONIST; LUTEINIZING HORMONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHILICITY; IC 50; IN VITRO STUDY; LUTEINIZING HORMONE RELEASE; MALE; MAMMAL; METHYLATION; NONHUMAN; RAT; REPORTER GENE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SUSTAINED RELEASE PREPARATION;

ANIMALS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENES, REPORTER; GONADOTROPIN-RELEASING HORMONE; HUMANS; LUCIFERASES; LUTEINIZING HORMONE; MALE; OLIGOPEPTIDES; ORCHIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 22744439296     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050134t     Document Type: Article

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