Synthesis and biological activity of GnRH antagonists modified at position 3 with 3-(2-methoxy-5-pyridyl)-alanine

Journal of Peptide Research

Volumn 65, Issue 2, 2005, Pages 284-291

  Samant, M P ^a   Miller, C ^a   Hong, D J ^b   Koerber, S C ^a   Croston, G ^b   Rivier, C L ^a   Rivier, J E ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Ferring Pharmaceuticals AS   (Denmark)

Author keywords

Antagonist; Degarelix; GnRH analogs; GnRH receptor; Gonadotropins; Proteinase K; Superagonist

Indexed keywords

ABARELIX; ALANINE; DEGARELIX; FE 200486; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; PROTEINASE K; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; IC 50; LUTEINIZING HORMONE RELEASE; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROSTATE CANCER; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE SYNTHESIS; STEREOCHEMISTRY;

ALANINE; ANIMALS; GONADOTROPIN-RELEASING HORMONE; MALE; OLIGOPEPTIDES; PYRIDINES; RATS; RECEPTORS, LHRH;

EID: 14744273418     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00219.x     Document Type: Article

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