Novel gonadotropin-releasing hormone antagonists with substitutions at position 5

Biopolymers - Peptide Science Section

Volumn 80, Issue 2-3, 2005, Pages 386-391

  Samant, Manoj P ^a   Hong, Doley J ^b   Croston, Glenn ^b   Rivier, Catherine ^a   Rivier, Jean ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b Ferring Pharmaceuticals AS   (Denmark)

Author keywords

Antagonist; Azaline B; GnRH receptor; Gonadotropin releasing hormone analogs; Superagonist; Therapeutic index; Therapeutic ratio

Indexed keywords

AROMATIC COMPOUNDS; COMPLEXATION; HYDROPHOBICITY; LIVING SYSTEMS STUDIES; SYNTHESIS (CHEMICAL);

2,5-DIMETHYOXYPHENYLACELYL; AROMATIC MOIETIES; AZALINE B; GONADOTROPIN-RELEASING HORMONE (GNRH) ANTAGONISTS;

HORMONES;

2,5 DIMETHOXYPHENYLACETYL DERIVATIVE; 3,5 DIMETHOXYPHENYLACETYL DERIVATIVE; ABARELIX; ACYLINE; AROMATIC COMPOUND; AZALINE; AZALINE B; CETRORELIX; DEGARELIX; GANIRELIX; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; GONADORELIN[ACETYL 1 DEXTRO 3 (2 NAPHTHYL)ALANINE 2 DEXTRO 4 CHLOROPHENYLALANINE 3 DEXTRO 3 (3 PYRIDYL)ALANINE 5 ARGININE (4 METHOXYBENZOYL) 6 DEXTRO 2 AMINOBUTYRIC ACID 10 DEXTRO ALANINE]; HOMOVANILLIC ACID; HOMOVERATOYL DERIVATIVE; ITURELIX; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CASTRATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; RECEPTOR BLOCKING;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; GONADOTROPIN-RELEASING HORMONE; HUMANS; MALE; MOLECULAR STRUCTURE; RATS; RECEPTORS, LHRH; RECOMBINANT PROTEINS;

EID: 20344408524     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.20195     Document Type: Article

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