-
2
-
-
1942499447
-
Time to draw breath: Asthma-susceptibility genes are identified
-
Wills-Karp, M. and Ewart, S.L. (2004) Time to draw breath: asthma-susceptibility genes are identified. Nat. Rev. Genet. 5, 376-387
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 376-387
-
-
Wills-Karp, M.1
Ewart, S.L.2
-
3
-
-
0141504373
-
Airway inflammation in childhood asthma
-
Barbato, A. et al. (2003) Airway inflammation in childhood asthma. Am. J. Respir. Crit. Care Med. 168, 798-803
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.168
, pp. 798-803
-
-
Barbato, A.1
-
4
-
-
0037214337
-
Early thickening of the reticular basement membrane in children with difficult asthma
-
Payne, D.N. et al. (2003) Early thickening of the reticular basement membrane in children with difficult asthma. Am. J. Respir. Crit. Care Med. 167, 78-82
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 78-82
-
-
Payne, D.N.1
-
5
-
-
0038160034
-
Histopathology of severe childhood asthma: A case series
-
Jenkins, H.A. et al. (2003) Histopathology of severe childhood asthma: a case series. Chest 124, 32-41
-
(2003)
Chest
, vol.124
, pp. 32-41
-
-
Jenkins, H.A.1
-
6
-
-
11144358047
-
Hyperplasia of smooth muscle in mild/moderate asthma without changes in cell size or gene expression
-
Woodruff, P.G. et al. (2004) Hyperplasia of smooth muscle in mild/moderate asthma without changes in cell size or gene expression. Am. J. Respir. Crit. Care Med. 169, 1001-1006
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.169
, pp. 1001-1006
-
-
Woodruff, P.G.1
-
7
-
-
0038544594
-
Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma
-
Schmidt, M. et al. (2003) Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J. Immunol. 171, 380-389
-
(2003)
J. Immunol.
, vol.171
, pp. 380-389
-
-
Schmidt, M.1
-
8
-
-
1242306794
-
Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
-
Kazi, A.S. et al. (2004) Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. Am. J. Physiol. 286, L539-L545
-
(2004)
Am. J. Physiol.
, vol.286
-
-
Kazi, A.S.1
-
9
-
-
0035986623
-
Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects
-
Westergren-Thorsson, G. et al. (2002) Correlation between airway responsiveness and proteoglycan production by bronchial fibroblasts from normal and asthmatic subjects. Int. J. Biochem. Cell. Biol. 34, 1256-1267
-
(2002)
Int. J. Biochem. Cell. Biol.
, vol.34
, pp. 1256-1267
-
-
Westergren-Thorsson, G.1
-
10
-
-
0347382406
-
Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration
-
Tufvesson, E. and Westergren-Thorsson, G. (2003) Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration. J. Cell. Sci. 116, 4857-4864
-
(2003)
J. Cell. Sci.
, vol.116
, pp. 4857-4864
-
-
Tufvesson, E.1
Westergren-Thorsson, G.2
-
11
-
-
0035662429
-
Airway inflammation is present during clinical remission of atopic asthma
-
van den Toorn, L.M. et al. (2001) Airway inflammation is present during clinical remission of atopic asthma. Am. J. Respir. Crit. Care Med. 164, 2107-2113
-
(2001)
Am. J. Respir. Crit. Care Med.
, vol.164
, pp. 2107-2113
-
-
Van Den Toorn, L.M.1
-
12
-
-
0036216744
-
Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma
-
Ward, C. et al. (2002) Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 57, 309-316
-
(2002)
Thorax
, vol.57
, pp. 309-316
-
-
Ward, C.1
-
13
-
-
0037365622
-
Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone
-
Chetta, A. et al. (2003) Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone. Am. J. Respir. Crit. Care Med. 167, 751-757
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 751-757
-
-
Chetta, A.1
-
14
-
-
0036268342
-
Expression of respiratory mucins in fatal status asthmaticus and mild asthma
-
Groneberg, D.A. et al. (2002) Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 40, 367-373
-
(2002)
Histopathology
, vol.40
, pp. 367-373
-
-
Groneberg, D.A.1
-
15
-
-
10744229972
-
Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: A five-month multicentre Canadian study
-
FitzGerald, J.M. et al. (2003) Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian study. Can. Respir. J. 10, 427-434
-
(2003)
Can. Respir. J.
, vol.10
, pp. 427-434
-
-
Fitzgerald, J.M.1
-
16
-
-
0035659190
-
Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes
-
Amrani, Y. et al. (2001) Interferon-gamma modulates cysteinyl leukotriene receptor-1 expression and function in human airway myocytes. Am. J. Respir. Crit. Care Med. 164, 2098-2101
-
(2001)
Am. J. Respir. Crit. Care Med.
, vol.164
, pp. 2098-2101
-
-
Amrani, Y.1
-
17
-
-
0038404961
-
CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4
-
Espinosa, K. et al. (2003) CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J. Allergy Clin. Immunol. 111, 1032-1040
-
(2003)
J. Allergy Clin. Immunol.
, vol.111
, pp. 1032-1040
-
-
Espinosa, K.1
-
18
-
-
0036140825
-
A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
-
Henderson, W.R. Jr. et al. (2002) A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am. J. Respir. Crit. Care Med. 165, 108-116
-
(2002)
Am. J. Respir. Crit. Care Med.
, vol.165
, pp. 108-116
-
-
Henderson Jr., W.R.1
-
19
-
-
11144355867
-
Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4
-
Yang, G. et al. (2004) Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4. Am. J. Physiol. 286, L992-L1001
-
(2004)
Am. J. Physiol.
, vol.286
-
-
Yang, G.1
-
20
-
-
0042624848
-
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
-
Woerly, G. et al. (2003) Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. J. Exp. Med. 198, 411-421
-
(2003)
J. Exp. Med.
, vol.198
, pp. 411-421
-
-
Woerly, G.1
-
21
-
-
0037373271
-
Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior antiinflammatory profile to corticosteroids: Relevance for chronic obstructive pulmonary disease therapy
-
Patel, H.J. et al. (2003) Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior antiinflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J. Immunol. 170, 2663-2669
-
(2003)
J. Immunol.
, vol.170
, pp. 2663-2669
-
-
Patel, H.J.1
-
22
-
-
1542329710
-
PPARγ ligands, 15-deoxy-Δ12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms
-
Ward, J.E. et al. (2004) PPARγ ligands, 15-deoxy-Δ12,14- prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. Br. J. Pharmacol. 141, 517-525
-
(2004)
Br. J. Pharmacol.
, vol.141
, pp. 517-525
-
-
Ward, J.E.1
-
23
-
-
0037438424
-
In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling
-
Fujitani, Y. and Trifilieff, A. (2003) In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am. J. Respir. Crit. Care Med. 167, 193-198
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 193-198
-
-
Fujitani, Y.1
Trifilieff, A.2
-
24
-
-
0141519355
-
Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma
-
Kumar, R.K. et al. (2003) Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma. J. Pharm. Exp. Ther. 307, 349-355
-
(2003)
J. Pharm. Exp. Ther.
, vol.307
, pp. 349-355
-
-
Kumar, R.K.1
-
25
-
-
0038036774
-
Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration
-
Goncharova, E.A. et al. (2003) Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration. Am. J. Respir. Cell Mol. Biol. 29, 19-27
-
(2003)
Am. J. Respir. Cell Mol. Biol.
, vol.29
, pp. 19-27
-
-
Goncharova, E.A.1
-
26
-
-
0142012148
-
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease
-
Gamble, E. et al. (2003) Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 168, 976-982
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.168
, pp. 976-982
-
-
Gamble, E.1
-
27
-
-
0041920928
-
Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine
-
Honda, K. et al. (2003) Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. J. Exp. Med. 198, 533-543
-
(2003)
J. Exp. Med.
, vol.198
, pp. 533-543
-
-
Honda, K.1
-
28
-
-
12444339842
-
Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2. 2. 1]heptane derivatives
-
Mitsumori, S. et al. (2003) Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 1. Bicyclo[2. 2. 1]heptane derivatives. J. Med. Chem. 46, 2436-2445
-
(2003)
J. Med. Chem.
, vol.46
, pp. 2436-2445
-
-
Mitsumori, S.1
-
29
-
-
0036968724
-
Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation
-
Cataldo, D.D. et al. (2002) Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation. Am. J. Pathol. 161, 491-498
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 491-498
-
-
Cataldo, D.D.1
-
30
-
-
0842300350
-
Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation
-
McMillan, S.J. et al. (2004) Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J. Immunol. 172, 2586-2594
-
(2004)
J. Immunol.
, vol.172
, pp. 2586-2594
-
-
McMillan, S.J.1
-
31
-
-
0036229419
-
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency
-
Corry, D.B. et al. (2002) Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency. Nat. Immunol. 3, 347-353
-
(2002)
Nat. Immunol.
, vol.3
, pp. 347-353
-
-
Corry, D.B.1
-
32
-
-
0142150951
-
Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure
-
Jain, V.V. et al. (2003) Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure. Am. J. Physiol. 285, L1137-L1146
-
(2003)
Am. J. Physiol.
, vol.285
-
-
Jain, V.V.1
-
33
-
-
0344393430
-
Inhibition of complement activation decreases airway inflammation and hyperresponsiveness
-
Taube, C. et al. (2003) Inhibition of complement activation decreases airway inflammation and hyperresponsiveness. Am. J. Respir. Crit. Care Med. 168, 1333-1341
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.168
, pp. 1333-1341
-
-
Taube, C.1
-
34
-
-
1242271091
-
A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma
-
Singer, M. et al. (2004) A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat. Med. 10, 193-196
-
(2004)
Nat. Med.
, vol.10
, pp. 193-196
-
-
Singer, M.1
-
35
-
-
0037173639
-
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
-
Van Eerdewegh, P. et al. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430
-
(2002)
Nature
, vol.418
, pp. 426-430
-
-
Van Eerdewegh, P.1
-
36
-
-
0035204919
-
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
-
McIntire, J.J. et al. (2001) Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. 2, 1109-1116
-
(2001)
Nat. Immunol.
, vol.2
, pp. 1109-1116
-
-
McIntire, J.J.1
-
37
-
-
9144221958
-
Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
-
Silverman, E.S. et al. (2004) Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma. Am. J. Respir. Crit. Care Med. 169, 214-219
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.169
, pp. 214-219
-
-
Silverman, E.S.1
-
38
-
-
0037603549
-
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin e levels and asthma
-
Zhang, Y. et al. (2003) Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat. Genet. 34, 181-186
-
(2003)
Nat. Genet.
, vol.34
, pp. 181-186
-
-
Zhang, Y.1
-
39
-
-
0242329880
-
Positional cloning of a novel gene influencing asthma from chromosome 2q14
-
Allen, M. et al. (2003) Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat. Genet. 35, 258-263
-
(2003)
Nat. Genet.
, vol.35
, pp. 258-263
-
-
Allen, M.1
-
40
-
-
0037769131
-
The Sic11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma
-
Smit, J.J. et al. (2003) The Sic11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma. J. Immunol. 171, 754-760
-
(2003)
J. Immunol.
, vol.171
, pp. 754-760
-
-
Smit, J.J.1
-
41
-
-
0043031428
-
Signaling molecules as therapeutic targets in allergic diseases
-
Gorska, M.M. and Alam, R. (2003) Signaling molecules as therapeutic targets in allergic diseases. J. Allergy Clin. Immunol. 112, 241-250
-
(2003)
J. Allergy Clin. Immunol.
, vol.112
, pp. 241-250
-
-
Gorska, M.M.1
Alam, R.2
-
42
-
-
0038657712
-
Emerging treatments for asthma
-
Blease, K. et al. (2003) Emerging treatments for asthma. Expert Opin. Emerg. Drugs 8, 71-81
-
(2003)
Expert Opin. Emerg. Drugs
, vol.8
, pp. 71-81
-
-
Blease, K.1
-
43
-
-
0036082554
-
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542
-
Laping, N.J. et al. (2002) Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol. Pharm. 62, 58-64
-
(2002)
Mol. Pharm.
, vol.62
, pp. 58-64
-
-
Laping, N.J.1
-
44
-
-
0036169380
-
A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma
-
Toda, M. et al. (2002) A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma. J. Allergy Clin. Immunol. 109, 246-250
-
(2002)
J. Allergy Clin. Immunol.
, vol.109
, pp. 246-250
-
-
Toda, M.1
|