Dicarboxylic acid azacycle L-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4772-4782

  Jarho, Elina M ^a   Wallén, Erik A A ^a   Christiaans, Johannes A M ^a,b   Forsberg, Markus M ^a   Venäläinen, Jarkko I ^a   Männistö, Pekka T ^a,c   Gynther, Jukka ^a   Poso, Antti ^a  

^a Department of Pharmaceutical Chemistry ^*  (Finland)

^b Altana Pharma bv   (Netherlands)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3,3 DIMETHYLGLUTARIC ACID AZEPANE PROLYL 2 CYANOPYRROLIDINAMIDE; AMIDE; DICARBOXYLIC ACID DERIVATIVE; PROLINE; PROLYL 2 CYANOPYRROLIDINE; PROLYL ENDOPEPTIDASE; PROLYL ENDOPEPTIDASE INHIBITOR; PROLYLPYRROLIDINAMIDE; PROLYLPYRROLIDINE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; COMPUTER PROGRAM; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; IC 50; LIPOPHILICITY; MOLECULAR DOCKING; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SEQUENCE ALIGNMENT; THREE DIMENSIONAL QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; AZA COMPOUNDS; BRAIN; DICARBOXYLIC ACIDS; MODELS, MOLECULAR; PROLINE; PYRROLIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SWINE;

EID: 22744434280     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0500020     Document Type: Article

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