Effect of ZTTA, a prolyl endopeptidase inhibitor, on memory impairment in a passive avoidance test of rats with basal forebrain lesions

Pharmaceutical Research

Volumn 15, Issue 12, 1998, Pages 1907-1910

  Shishido, Yoshiyuki ^a   Furushiro, Masayoshi ^a   Tanabe, Shuichi ^a   Taniguchi, Akira ^b   Hashimoto, Shusuke ^a   Yokokura, Teruo ^a   Shibata, Shigenobu ^c   Yamamoto, Tsuneyuki ^b   Watanabe, Shigenori ^b  

^a YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c WASEDA UNIVERSITY   (Japan)

Author keywords

Basal forebrain lesion; Choline acetyltransferase; N benzyloxycarbonyl thioprolythioprolinal dimethylacetal (ZTTA); PEP inhibitor; Prolyl endopeptidase (PEP); Step through type passive avoidance test

Indexed keywords

N BENZYLOXYCARBONYLTHIOPROLYTHIOPROLINAL DIMETHYLACETAL; PROLYL ENDOPEPTIDASE INHIBITOR; PROTEINASE; UNCLASSIFIED DRUG;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; BRAIN INJURY; DRUG EFFECT; DRUG PROTEIN BINDING; NONHUMAN; ORAL DRUG ADMINISTRATION; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT;

ANIMALS; AVOIDANCE LEARNING; CHOLINE O-ACETYLTRANSFERASE; ENZYME INHIBITORS; MALE; MEMORY DISORDERS; NEURONS; PROSENCEPHALON; RATS; RATS, WISTAR; SERINE ENDOPEPTIDASES; THIAZOLES;

EID: 0032411127     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011922526538     Document Type: Article

References (14)

1. T. Yoshimoto, K. Ogita, M. Walter, M. Koida, and D. Tsuru. Post-proline cleaving enzyme. Biochim. Biophys. Acta 569:184-192 (1979).
2. N. Miura, S. Shibata, and S. Watanabe. Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats. Neurosci. Lett. 196:128-130 (1995).
3. K. Toide, M. Shinoda, Y. Iwamoto, T. Fujiwara, K. Okamiya, and A. Uemura. A novel prolyl endopeptidase inhibitor, JTP-4819, with potential for treating Alzheimer's disease. Behav. Brain Res. 83:147-151 (1997).
4. D. L. Price, P. J. Whitehouse, R. G. Struble, A. W. Clark, J. T. Coyle, M. R. Delong, and J. C. Hedreen. Basal forebrain cholinergic systems in Alzheimer's disease and related dementias. Neurosci. Comment 1:84-92 (1982).
5. M. V. Johnston, M. McKinney, and J. T. Coyle. Evidence for a cholinergic projection to neocortex from neurons in basal forebrain. Proc. Natl. Acad. Sci. U.S.A. 76:5392-5396 (1979).
6. M. V. Johnston, M. McKinney, and J. T. Coyle. Neocortical cholinergic innervation: a description of extrinsic and intrinsic components in the rat. Exp. Brain Res. 43:159-172 (1981).
7. Y. Shishido, M. Furushiro, S. Tanabe, S. Nishiyama, S. Hashimoto, M. Ohno, T. Yamamoto, and S. Watanabe. ZTTA, a post proline cleaving enzyme inhibitor, improves cerebral ischemia-induced deficits in a three-panel runway task in rats. Pharmacol. Biochem. Behav. 55:333-338 (1996).
8. G. Paxinos and C. Watson. The rat brain in stereotaxic coordinates, Academic Press, New York, 1982.
9. M. Miyamoto, S. Narumi, A. Nagaoka, and J. T. Coyle. Effects of continuous infusion of cholinergic drugs on memory impairment in rats with basal forebrain lesions. J. Pharmacol. Exp. Ther. 248:825-835 (1989).
10. S. Nakamura, Y. Tani, Y. Maezono, T. Ishihara, and T. Ohno. Learning deficits after unilateral AF64A lesions in the rat basal forebrain. Pharmacol. Biochem. Behav. 42:119-130 (1992).
11. F. A. Fonnum. Rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:407-409 (1975).
12. K. Toide, M. Shinoda, M. Takase, K. Iwata, and H. Yoshida. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur. J. Pharmacol. 233:21-28 (1993).
13. H. Maegawa, N. Katsube, T. Okegawa, H. Aishita, and A. Kawasaki. Arginine-vasopressin fragment 4-9 stimulates the acetylcholine release in hippocampus of freely-moving rats. Life Sci. 51:285-293 (1992).
14. 8-vasopressin affects catecholamine metabolism in specific brain nuclei. Life Sci. 20:1799-1808 (1977).