Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819

Biochemical Pharmacology

Volumn 64, Issue 3, 2002, Pages 463-471

  Venäläinen, Jarkko I ^a   Juvonen, Risto O ^a   Forsberg, Markus M ^a   Garcia Horsman, Arturo ^a   Poso, Antti ^a   Wallen, Erik A A ^a   Gynther, Jukka ^a   Männistö, Pekka T ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Enzyme kinetics; Prolyl oligopeptidase; Serine protease; Substrate inhibition; Tight binding inhibition

Indexed keywords

COUMARIN DERIVATIVE; N BENZYL 2 [[2 (HYDROXYACETYL) 1 PYRROLIDINYL]CARBONYL] 1 PYRROLIDINECARBOXAMIDE; N BENZYLOXYCARBONYLGLYCYLPROLYL 7 AMINO 4 METHYLCOUMARIN; N SUCCINYLGLYCYLPROLYL 7 AMINO 4 METHYLCOUMARIN; PROLYL ENDOPEPTIDASE; PROLYL ENDOPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN HOMOGENATE; CALCULATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; IC 50; MICHAELIS CONSTANT; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SIMULATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; PROTEASE INHIBITORS; PYRROLIDINES; SERINE ENDOPEPTIDASES; SWINE;

EID: 0036683705     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01184-X     Document Type: Article

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