Chemical genomics for fast and integrated target identification and lead optimization

Medicinal Chemistry Research

Volumn 13, Issue 8-9, 2004, Pages 643-659

  Darvas, Ferenc ^a   Dormán, György ^a   Puskás, László G ^b   Bucsai, Ágota ^a   Ürge, László ^a  

^a ComGenex Inc ^*  (Hungary)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BUTANEDIOL; BENZAMIDINE; BIOTIN; EPICHLOROHYDRIN; STREPTAVIDIN;

ANTIGEN ANTIBODY COMPLEX; BINDING AFFINITY; CELL ASSAY; CONFERENCE PAPER; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENETIC MANIPULATION; HIGH THROUGHPUT SCREENING; MICROTITER PLATE ASSAY; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN TARGETING; SOLID PHASE SYNTHESIS; STRUCTURAL GENOMICS; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; TISSUE MICROARRAY;

EID: 22644438047     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-004-0108-5     Document Type: Conference Paper

References (16)

1. Chemical Genomics, Editors. Ferenc Darvas, András Guttman, György Dormán, Marcel Dekker, (in press)
2. F Darvas, G Dormán, P Krajcsi, L Puskás, Z Kovári, Zs Lorincz and L Ürge Recent Advances in Chemical Genomics, Curr. Med. Chem. (in press)
3. H Kessmann, HA Ottleben. A Shortcut on the Long Road to Drug Discovery. Innovation in Pharm Tech 2001, 24-27.
4. T Oprea, J Gottfries. Toward Minimalistic Modeling of Oral Drug Absorption. J Mol Graphics Model 1999 17:261-274.
5. CA Lipinski, F Lombardo, BW Dominy, PJ Feeney. Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings. Adv Drug Delivery Rev 1997, 23:3.
6. DM Maly, IC Choong, JA Ellman. Combinatorial Target-Guided Ligand Assembly. Identification of Potent, Sub-type Selective c-Src Inhibitors. Proc Nat Acad Sci 2000, 97:2419-2424.
7. GR Metz, H Ottleben, D. Vetter. Small molecule screening on chemical microarrays. In: Molecular recognition in Protein-Ligand Interactions, Eds. H.-J. Böhm, G. Schneider, Wiley-VCH, New York, Weinheim, (in press)
8. B Lin, J Qiu, J Gerstenmeier, P Li, H Pien, J Pepper, Cunningham B. Related Articles, Links Abstract A label-free optical technique for detecting small molecule interactions. Biosens Bioelectron. 2002 Sep; 17(9): 827-34.
9. H Wenschuh, R Volkmer-Engert, M Schulz, J Schneider-Mergener, U Reineke. Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides. Biopolymers 2000, 55:188-206.
10. R Frank. The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports-principles and applications. J Immunol Methods 2002, 267:13-26.
11. SP Fodor, JL Read, MC Pirrung, L Stryer, AT Lu, D Solas. Light-directed, spatially addressable parallel chemical synthesis. Science 1991, 251:767-773, 1991.
12. G MacBeath, AN Koehler, SL Schreiber SL. Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J Am Chem Soc 1999, 121:7967-7968.
13. S Freundlieb, J Gamer. Chemical Microarrays: A Novel Approach to Drug Discovery. New Drugs 2002, 3:54-60.
14. L Hackler Jr., G Dormán, Z Kele, L Ürge, F Darvas and L G. Puskás, Development of chemically modified glass surfaces for nucleic acid, protein and small molecule microarrays, Mol Div. 2003, 7, 25-36.
15. F Darvas, G Dorman, L Ürge, I Szabó, Z Rónai, M Sasváry-Székely. Combinatorial Chemistry. Facing the Challenge of Chemical Genomics. Pure Appl Chem 2001, 73:1487-1498.
16. G Dormán, P Krajcsi, L Ürge, F Darvas. Novel chemical genomics approaches to one-step hit discovery and target identification/ validation. Pharma Chem 2002, 1:13-16.