Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors

International Journal of Immunogenetics

Volumn 32, Issue 4, 2005, Pages 229-232

  Eklund, Carita ^a,c   Lehtimakit T ^b   Hurme, M ^a,b  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1BETA;

ADULT; ALLELE; ARTICLE; BLOOD DONOR; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC EPISTASIS; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FOLDING; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

BLOOD DONORS; C-REACTIVE PROTEIN; EPISTASIS, GENETIC; FEMALE; GENE FREQUENCY; GENOTYPE; HEALTH; HUMANS; INTERLEUKIN-1; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS;

EID: 22644433812     PISSN: 17443121     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1744-313X.2005.00515.x     Document Type: Article

References (25)

1. Agrawal, A., Cha-Molstad, H., Samols, D. & Kushner, I. (2001) Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein beta (C/EBP beta) and Rel p50. The Journal of Immunology, 166, 2378.
2. Berger, P., McConnell, J.P., Nunn, M., Kornman, K.S., Sorrell, J., Stephenson, K. & Duff, G.W. (2002) C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine, 17, 171.
3. Brull, D.J., Serrano, N., Zito, F., Jones, L., Montgomery, H.E., Rumley, A. et al. (2003) Human CRP gene polymorphism influences CRP levels. Arteriosclerosis Thrombosis and Vascular Biology, 23, 2063.
4. Cao, H. & Hegele, R.A. (2000) Human C-reactive protein (CRP) 1059G/C polymorphism. Journal of Human Genetics, 45, 100.
5. Cha-Molstad, H., Agrawal, A., Zhang, D., Samols, D. & Kushner, I. (2000) The Rel family member P50 mediates cytokine-induced C-reactive protein expression by a novel mechanism. The Journal of Immunology, 165, 4592.
6. Danesh, J., Whincup, P., Walker, M., Lennon, L., Thomson, A., Appleby, P., Gallimore, J.R. & Pepys, M.B. (2000) Low grade inflammation and coronary heart disease: prospective study and updated meta-analysis. British Medical Journal, 321, 199.
7. Dominici, R., Malferrari, G., Mariani, C., Grimaldi, L. & Biunno, I. (2002) The interleukin 1-beta exonic (+3953) polymorphism does not alter in vitro protein secretion. Experimental Molecular Pathology, 73, 139.
8. Eklund, C., Jahan, F., Pessi, T., Lehtimaki, T. & Hurme, M. (2003) IL1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals. European Cytokine Network, 14, 168.
9. Erlandsen, E.J. & Randers, E. (2000) Reference interval for serum C-reactive protein in healthy blood donors using the Dade Behring N Latex CRP mono assay. Scandinavian Journal of Clinical Laboratory Investigations, 60, 37.
10. Ferrari, S.L., Ahn-Luong, L., Garnero, P., Humphries, S.E. & Greenspan, S.L. (2003) Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. Journal of Clinical Endocrinological Metabolism, 88, 255.
11. Hefler, L.A., Tempfer, C.B., Unfried, G., Schneeberger, C., Lessl, K., Nagele, F. & Huber, J.C. (2001) A polymorphism of the interleukin-1 beta gene and idiopathic recurrent miscarriage. Fertility and Sterility, 76, 377.
12. MacGregor, A.J., Gallimore, J.R., Spector, T.D. & Pepys, M.B. (2004) Genetic effects on baseline values of C-reactive protein and serum amyloid A protein: a comparison of monozygotic and dizygotic twins. Clinical Chemistry, 50, 130.
13. Margaglione, M., Bossone, A., Cappucci, G., Colaizzo, D., Grandone, E. & Di Minno, G. (2001) The effect of the interleukin-6c/g-174 polymorphism and circulating interleukin-6 on fibrinogen plasma levels. Haematologica, 86, 199.
14. Pankow, J.S., Folsom, A.R., Cushman, M., Borecki, I.B., Hopkins, P.N., Eckfeldt, J.H. & Tracy, R.P. (2001) Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis, 154, 681.
15. Pociot, F., Molvig, J., Wogensen, L., Worsaae, H. & Nerup, J. (1992) A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. European Journal of Clinical Investigations, 22, 396.
16. Santtila, S., Savinainen, K. & Hurme, M. (1998) Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1 beta production in vitro. Scandinavian Journal of Immunology, 47, 195.
17. Szalai, A.J., van Ginkel, EW., Wang, Y., McGhee, J.R. & Volanakis, J.E. (2000) Complement-dependent acute-phase expression of C-reactive protein and serum amyloid P-component. Journal of Immunology, 165, 1030.
18. Szalai, A.J., McCrory, M.A., Cooper, G.S., Wu, J. & Kimberly, R.P. (2002) Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Genes and Immunity, 3, 14.
19. Tamakoshi, K., Yatsuya, H., Kondo, T., Hori, Y., Ishikawa, M., Zhang, H., Murata, C., Otsuka, R., Zhu, S. & Toyoshima, H. (2003) The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. International Journal of Obesity, 27, 443.
20. Tchernof, A., Nolan, A., Sites, C.K., Ades, P.A. & Poehlman, E.T. (2002) Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation, 105, 564.
21. Vickers, M.A., Green, F.R., Terry, C., Mayosi, B.M., Julier, C., Lathrop, M., Ratcliffe, P.J., Watkins, H.C. & Keavney, B. (2002) Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovascular Research, 53, 1029.
22. Weinhold, B. & Ruther, U. (1997) Interleukin-6-dependent and -independent regulation of the human C-reactive protein gene. Biochemistry Journal, 327, 425.
23. Wieser, F., Hefler, L., Tempfer, C., Vlach, U., Schneeberger, C., Huber, J. & Wenzl, R. (2003) Polymorphism of the interleukin-1 beta gene endometriosis. Journal of the Society of Gynecological Investigation, 10, 172.
24. Zee, R.Y. & Ridker, P.M. (2002) Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis, 162, 217.
25. Zheng, H., Fletcher, D., Kozak, W., Jiang, M., Hofmann, K.J., Conn, C.A. et al. (1995) Resistance to fever induction and impaired acute-phase response in interleukin-1 beta deficient mice. Immunity, 3, 9.