Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals

European Cytokine Network

Volumn 14, Issue 3, 2003, Pages 168-171

  Eklund, Carita ^a,c   Jahan, Farhana ^a   Pessi, Tanja ^a   Lehtimäki, Terho ^b   Hurme, Mikko ^a,b  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

CRP; IL1B; Immunogenetics; Inflammation; Polymorphisms

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN RECEPTOR;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD DONOR; CONTROLLED STUDY; DATA ANALYSIS; DNA POLYMORPHISM; FEMALE; GENE FUNCTION; GENE LOCUS; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOGENETICS; MALE; NORMAL HUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BASE SEQUENCE; C-REACTIVE PROTEIN; DNA PRIMERS; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-1; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; REFERENCE VALUES;

EID: 0141957373     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Dinarello CA. 1996. Biologic basis for interleukin-1 in disease. (Review) Blood 87: 2095.
2. Steel DM, Whitehead AS. 1994. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. (Review) Immunol. Today 15: 81.
3. Gabay C, Kushner I. 1999. Acute phase proteins and other systemic responses to inflammation. (Review) N. Engl. J. Med. 340: 448.
4. Weinhold B, Bader A, Poli V, Ruther U. 1997. Interleukin-6 is necessary, but not sufficient, for induction of the C-reactive protein gene in vivo. Biochem. J. 325: 617.
5. Pankow JS, Folsom AR, Cushman M, Borecki IB, Hopkins PN, Eckfeldt JH, Tracy RP. 2001. Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study. Atherosclerosis 154: 681.
6. Vickers MA, Green FR, Terry C, Mayosi BM, Julier C, Lathrop M, Ratcliffe PJ, Watkins HC, Keavney B. 2002. Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc. Res. 53: 1029.
7. Cha-Molstad H, Agrawal A, Zhang D, Samols D, Kushner I. 2000. The Rel family member p50 mediates cytokine-induced C-reactive protein expression by a novel mechanism. J. Immunol. 165: 4592.
8. Agrawal A, Cha-Molstad H, Samols D, Kushner I. 2001. Transactivation of C-reactive protein by IL-6 requires synergistic interaction of CCAAT/enhancer binding protein β (C/EBPβ) and Rel p50. J. Immunol. 166: 2378.
9. Zee RY, Ridker PM. 2002. Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis 162: 217.
10. Szalai AJ, McCrory MA, Cooper GS, Wu J, Kimberly RP. 2002. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Genes Immun. 3: 14.
11. Koenig W, Sund M, Frohlich M, Fischer HG, Lowel H, Doring A, Hutchinson WL, Pepys MB. 1999. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results form the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Ausburg Cohort study, 1984 to 1992. Circulation 99: 237.
12. Mendall MA, Patel P, Ballam L, Strachan D, Northfield TC. 1996. C-reactive protein and its relation to cardiovascular risk factors: a population based cross-sectional study. Br. Med. J. 312: 1061.
13. Danesh J, Whincup P, Walker M, Lennon L, Thompson A, Appleby P, Gallimore JR, Pepys MB. 2000. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses. Br. Med. J. 321: 199.
14. Ridker P, Cushman M, Stampter M, Tracy R, Hennekens CH. 1997. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336: 973.
15. Lagrand WK, Visser CA, Hermens WT, Niessen HW, Verheugt FW, Wolbink GJ, Hack CE. 1999. C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? (Review) Circulation 100: 96.
16. Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN, Steinkasserer A, Duff GN. 1993. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum. Genet. 91: 403.
17. di Giovine FS, Takhsh E, Blakemore AI, Duff GW. 1992. Single base polymorphism at -511 in the human interleukin-1β gene (IL1β). Hum. Mol. Genet. 1: 450.
18. Pociot F, Mølvig J, Wogensen H, Worsaaae H, Nerup J. 1992. A TaqI polymorphism in the human interleukin-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur. J. Clin. Invest. 22: 396.
19. McDowell TL, Symons JA, Ploski R, Førre O, Duff GW. 1995. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 a polymorphism. Arthritis. Rheum. 38: 221.
20. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P. 1998. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102: 1369.
21. Erlandsen EJ, Randers E. 2000. Reference interval for serum C-reactive protein in healthy blood donors using the Dade Behring N Latex CRP mono assay. Scan. J. Clin. Lab. Invest. 60: 37.
22. Lewontin RC. 1988. On measures of gametic disequilibrium. Genetics 120: 849.
23. Santtila S, Savinainen K, Hurme M. 1998. Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1β production in vitro. Scand. J. Immunol. 47: 195.
24. Berger P, McConnell JP, Nunn M, Kornman KS, Sorrell J, Stephenson K, Duff GW. 2002. C-reactive protein levels are influenced by common IL-1 gene variations. Cytokine 17: 171.
25. Reich DE, Cargill M, Bolk S, Ireland J, Sabeti PC, Richter DJ, Lavery T, Kouyoumjian R, Farhadian SF, Ward R, Lander ES. 2001. Linkage disequilibrium in the human genome. Nature 411: 199.
26. Kornman KS, Pankow J, Offenbacher S, Beck J, di Giovine F, Duff GW. 1999. Interleukin-1 genotypes and the association between periodontitis and cardiovascular disease. J. Periodontal. Res. 34: 353.