Exacerbation of toxoplasmosis in neutrophil-depleted mice

Natural Immunity

Volumn 15, Issue 5, 1997, Pages 249-258

  Sayles, Peter C ^a   Johnson, Lawrence L ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

Flow cytometry; Inbred mice; Monoclonal antibody; Neutrophils; Toxoplasma gondii

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEMALE; INFECTION RESISTANCE; MALE; MOUSE; NEUTROPENIA; NEUTROPHIL; NONHUMAN; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; IMMUNITY, NATURAL; INTERFERON TYPE II; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED C57BL; NEUTROPENIA; NEUTROPHILS; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TOXOPLASMOSIS, CEREBRAL; WEIGHT LOSS;

EID: 1842308284     PISSN: 10188916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A: Interleukin 12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induced resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993;90:6115-6119.
2. Sher A, Oswald IP, Hieny S, Gazzinelli RT: Toxoplasma gondii induces a T-independent IFN-γ response in natural killer cells that requires both adherent accessory cells and tumor necrosis factor-α. J Immunol 1993;150:3982-3989.
3. Johnson LL: A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection. Infect Immun 1992;60:1979-1983.
4. Johnson LL, VanderVegt FP, Havell EA: Gamma interferon-dependent temporary resistance to acute Toxoplasma gondii infection independent of CD4+ and CD8+ lymphocytes. Infect Immun 1993;61:5174-5180.
5. Langermans JAM, van der Hulst MEB, Nibbering PH, Hiemstra PS, Fransen L, van Furth R: IFN-γ induced L-arginine dependent toxoplasmatic activity in murine peritoneal macrophages is mediated by endogenous tumor necrosis factor-α. J Immunol 1992;148:568-574.
6. Johnson LL, Gibson GW, Sayles PC: CR3-dependent resistance to acute Toxoplasma gondii infection in mice. Infect Immun 1996;64: 1998-2003.
7. Rosen H, Gordon S: Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. J Exp Med 1987;166:1685-1701.
8. Wilson CB, Remington JS: Activity of human blood leukocytes against Toxoplasma gondii. J Infect Dis 1979;140:890-895.
9. Konishi E, Nakao M: Naturally occurring immunoglobulin M antibodies: Enhancement of phagocytic and microbicidal activities of human neutrophils against Toxoplasma gondii. Parasitology 1992; 104-427-432.
10. Remington JS, Desmonts G: Toxoplasmosis; in Remington JS, Klein JO (eds): Infectious Diseases of the Fetus and Newborn Infant. Philadelphia, Saunders, 1976, pp 191-332.
11. Tepper RI, Coffman RL, Leder P: An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Science 1992;257:548-551.
12. Conlan JW, North RJ: Neutrophils are essential for early anti-listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J Exp Med 1994;179:259-268.
13. Czuprynski CJ, Brown JF, Maroushek N, Wagner RD, Steinberg H: Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection. J Immunol 1994; 152:1836-1846.
14. Smith JA: Neutrophils, host defense, and inflammation: A double-edged sword. J Leukoc Biol 1994;56: 672-686.
15. Sayles PC, Johnson LL: Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii. Infect Immun 1996;64:3088-3092.
16. Johnson LL, Gibson GW, Sayles PC: Toxoplasma gondii: Effect of sublethal irradiation on host resistance in mice. Exp Parasitol 1995; 81:172-181.
17. Goossens PL, Jouin H, Milon G: Dynamics of lymphocytes and inflammatory cells recruited in liver during murine listeriosis. J Immunol 1991;147:3514-3520.