Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells

Cancer Biology and Therapy

Volumn 3, Issue 12, 2004, Pages 1304-1312

  Keen, Judith C ^a   Garrett Mayer, Elizabeth ^a   Pettit, Catherine ^a   Mack, Kelly M ^a,b   Manning, Jasper ^a   Herman, James G ^a   Davidson, Nancy E ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF MARYLAND EASTERN SHORE   (United States)

Author keywords

5 aza 2 deoxycytidine; Breast cancer; DNA methylation; Epigenetic; Histone acetylation; Trichostatin A

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BICARBONATE SODIUM COTRANSPORTER; ESTROGEN RECEPTOR ALPHA; LYMPHOTACTIN; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; THY 1 ANTIGEN; TRICHOSTATIN A; AZACITIDINE; DNA METHYLTRANSFERASE; DRUG DERIVATIVE; GAMMA CHEMOKINE; HISTONE DEACETYLASE; HYDROXAMIC ACID; LYMPHOKINE; PHOSPHOPROTEIN PHOSPHATASE; PROGESTERONE RECEPTOR; RNA; SIALOGLYCOPROTEIN; XCL1 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; CANCER CELL; CELL STIMULATION; DEGRADATION; DNA MICROARRAY; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC REGULATION; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; ACETYLATION; BREAST TUMOR; CELL CULTURE; DNA METHYLATION; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLATION; AZACITIDINE; BREAST NEOPLASMS; CHEMOKINES, C; DNA METHYLATION; DNA MODIFICATION METHYLASES; EPIGENESIS, GENETIC; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LYMPHOKINES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEIN PHOSPHATASE; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; SIALOGLYCOPROTEINS; TUMOR CELLS, CULTURED;

EID: 22344439580     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.12.1458     Document Type: Article

References (37)

1. Keen JC, Davidson NE. The biology of breast carcinoma. Cancer 2003; 97:825-33.
2. Cheung W, Briggs S, Allis C. Acetylation and chromosomal functions. Curr Opin Cell Biol 2000; 12:326-33.
3. Bird A. Methylation talk between histones and DNA. Science 2001; 294:2113-2115.
4. Bird A, Wolffe A. Methylation-induced repression - belts, braces, and chromatin. Cell 1999; 99:451-4.
5. Ferguson AT, Vertino P, Spitzner J, Baylin S, Muller M, Davidson NE. Role of estrogen receptor gene demethylation and DNA methyltransferase-DNA adduct formation in 5-aza-2′-deoxycytidine-induced cytotoxicity in human breast cancer cells. J Biol Chem 1997; 272:32260-6.
6. Ottaviano Y, Issa J, Pari F, Smith H, Baylin S, Davidson N. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res 1994; 54:2552-5.
7. Yang X, Ferguson AT, Nass SJ, Phillips DL, Butash KA, Wang SM, Herman JG, Davidson NE. Transcriptional activation of estrogen receptor α in human breast cancer cells by histone deacetylase inhibition. Cancer Res 2000; 60:6890-4.
8. Yang X, Phillips DL, Ferguson AT, Nelson WG, Herman JG, Davidson NE. Synergistic activation of functional estrogen receptor (ER)-α by DNA methyltransferase and histone deacetylase inhibition in human ER-α-negative breast cancer cells. Cancer Research 2001; 61:7025-9.
9. Bird A. CpG-rich islands and the function of DNA methylation. Nature 1986; 321:209-13.
10. Bestor T. Cloning of a mammalian DNA methyltransferase. Gene 1988; 74:9-12.
11. Bestor T, Verdine G. DNA methyltransferases. Curr Opin Cell Biol 1994; 6:380-9.
12. Lee K, Hayes J, Pruss D, Wolffe A. A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 1993; 72:73.
13. Jenuwein T, Allis CD. Translating the histone code. Science 2001; 293:1074-80.
14. Nan X, Ng H-H, Johnson C, Laherty C, Turner B, Eisenman R, Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 1998; 393:386.
15. Razin A. CpG methylation, chromatin structure and gene silencing - a three way connection. EMBO J 1998; 17:4905.
16. Lapidus R, Ferguson AT, Ottaviano Y, Parl F, Smith H, Weitzman S, Baylin S, Issa J, Davidson NE. Methylation of estrogen and progesterone receptor 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors. Clin Cancer Res 1996; 2:805-10.
17. Ferguson AT, Lapidus R, Baylin S, Davidson NE. Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res 1995; 55:2279-83.
18. Keen JC, Yan L, Mack K, Pettit C, Smith D, Sharma D, Davidson NE. A novel histone deacetylase inhibitor, Scriptaid, enhances expression of functional estrogen receptor α(ER) in ER negative human breast cancer cells in combination with 5-aza-2′ deoxycytidine. Breast Cancer Res and Treat 2003; 81:177-86.
19. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostat 2003; 4:249-64.
20. Li L-C, Dahiya R. MethPrimer: Designing primers for methylation PCRs. Bioinformatics 2002; 18:1427-31.
21. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. PNAS 1996; 93:9821-6.
22. Wijayaratne AL, McDonnell DP. The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem 2001; 276:35684-92.
23. Shi H, Wei SH, Leu Y-W, Rahmatpanah F, Liu JC, Yan PS, Nephew KP, Huang TH-M. Triple analysis of the cancer epigenome: An integrated microarray system for assessing gene expression, DNA methylation, and histone acetylation. Cancer Res 2003; 63:2164-71.
24. Milutinovic S, Zhuang Q, Niveleau A, Szyf M. Epigenetic stress response: Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem 2003; 278:14985-95.
25. Shi H, Yan PS, Chen C-M, Rahmatpanah F, Lofton-Day C, Caldwell CW, Huang TH-M. Expressed CpG island sequence tag microarray for dual screening of DNA hypermethylation and gene silencing in cancer cells. Cancer Res 2002; 62:3214-20.
26. van der Velden P, Zuidervaart W, Hurks M, Pavey S, Ksander B, Krijgsman E, Frants R, Tensen C, Willemze R, Jager M, Gruis N. Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development. Int J Cancer 2003; 106:472-9.
27. Suzuki H, Gabrielson E, Chen W, Anbazhagan R, Van Engeland M, Weijenberg M, Herman JG, Baylin S. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002; 31:141-9.
28. Yan PS, Shi H, Rahmatpanah F, Hsiau TH-C, Hsiau AH-A, Leu Y-W, Liu JC, Huang TH-M. Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer. Cancer Res 2003; 63:6178-86.
29. Abeysinghe HR, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert NL, Keng P, Wang N. THY1 expression is associated with tumor suppression of human ovarian cancer. Cancer Genetics and Cytogenetics 2003; 143:125-32.
30. Cao Q, Abeysinghe H, Chow O, Xu J, Kaung H-L, Fong C-T, Keng P, Insel RA, Lee W-CM, Barrett JC, Wang N. Suppression of tumorigenicity in human ovarian carcinoma cell line SKOV-3 by microcell-mediated transfer of chromosome 11. Cancer Genet Cytogenet 2001; 129:131-7.
31. Rousseau RF, Haight AE, Hirschmann-Jax C, Yvon ES, Rill DR, Mei Z, Smith SC, Inman S, Cooper K, Alcoser P, Grilley B, Gee A, Popek E, Davidoff A, Bowman LC, Brenner MK, Strother D. Local and systemic effects of an allogeneic tumor cell vaccine combining transgenic human lymphotactin with interleukin-2 in patients with advanced or refractory neuroblastoma. Blood 2003; 101:1718-26.
32. Wang Q, Yu H, Zhang L, Ju D, Pan J, Xia D, Yao H, Zhang W, Wang J, Cao X. Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer. J Mol Med 2002; 80:585-94.
33. Xia D, Zhang W, Zheng S, Wang J, Pan J, Wang Q, Zhang L, Hamada H, Cao X. Lymphotactin contransfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100. Gene Ther 2002; 9:592-601.
34. Zolnierowicz S. Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Biochem Pharmacol 2000; 60:1225-35.
35. Gopalakrishna R, Gundimeda U, Fontana JA, Clarke R. Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett 1999; 136:143-51.
36. Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small cpguanine-rich region correlates with loss of activator protein-2{alpha} expression during progression of breast cancer. Cancer Res 2004; 64:1611-20.
37. Sirchia SM, Ren M, Pili R, Sironi E, Somenzi G, Ghidoni R, Toma S, Nicolo G, Sacchi N. Endogenous reactivation of the RARβ2 tumor suppressor gene epigenetically silenced in breast cancer. Cancer Res 2002; 62:2455-61.