FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice

Journal of Cell Biology

Volumn 169, Issue 4, 2005, Pages 591-601

  Yu, Vionnie W C ^a,b   Ambartsoumian, Gourgen ^a   Verlinden, Lieve ^a,c   Moir, Janet M ^a   Prud'homme, Josée ^a   Gauthier, Claude ^a   Roughley, Peter J ^a,b   St Arnaud, René ^a,b  

^a SHRINERS HOSPITAL FOR CHILDREN   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALKALINE PHOSPHATASE; FACTOR INHIBITING ACTIVATING TRANSCRIPTION FACTOR 4 MEDIATED TRANSCRIPTION; LEUCINE ZIPPER PROTEIN; NUCLEAR PROTEIN; OSTEOCALCIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE MINERALIZATION; CELL ACTIVITY; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN SYNTHESIS; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; IN VITRO STUDY; LONG BONE; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN INTERACTION; REGULATORY MECHANISM; RIGIDITY; TRABECULAR BONE; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; BONE AND BONES; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; CARRIER PROTEINS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REGULATOR; LEUCINE ZIPPERS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; OSTEOGENESIS; REPRESSOR PROTEINS; TRANS-ACTIVATORS;

MUS MUSCULUS;

EID: 22344437860     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200412139     Document Type: Article

References (46)

1. Andrews, N.C., and D.V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
2. Ausubel, F.M., R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. 1993. Enzymatic manipulation of DNA and RNA. In Current Protocols in Molecular Biology. John Wiley and Sons, NY. 3.5.7-3.5.9.
3. Bialek, P., B. Kern, X. Yang, M. Schrock, D. Sosic, N. Hong, H. Wu, K. Yu, D.M. Ornitz, E.N. Olson, et al. 2004. A twist code determines the onset of osteoblast differentiation. Dev. Cell. 6:423-435.
4. Boyle, W.J., W.S. Simonet, and D.L. Lacey. 2003. Osteoclast differentiation and activation. Nature. 423:337-342.
5. Burleigh, M.C., A.J. Barrett, and G.S. Lazarus. 1974. Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem. J. 137:387-398.
6. Chevray, P.M., and D. Nathans. 1992. Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun. Proc. Natl. Acad. Sci. USA. 89:5789-5793.
7. Dacquin, R., M. Starbuck, T. Schinke, and G. Karsenty. 2002. Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast. Dev. Dyn. 224:245-251.
8. Ducy, P., and G. Karsenty. 1995. Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol. Cell. Biol. 15:1858-1869.
9. Ducy, P., C. Desbois, B. Boyce, G. Pinero, B. Story, C. Dunstan, E. Smith, J. Bonadio, S. Goldstein, C. Gundberg, et al. 1996. Increased bone formation in osteocalcin-deficient mice. Nature. 382:448-452.
10. Ducy, P., R. Zhang, V. Geoffroy, A.L. Ridall, and G. Karsenty. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 89:747-754.
11. Ecarot-Charrier, B., F.H. Glorieux, M. van der Rest, and G. Pereira. 1983. Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture. J. Cell Biol. 96:639-643.
12. Erlebacher, A., E.H. Filvaroff, S.E. Gitelman, and R. Derynck. 1995. Toward a molecular understanding of skeletal development. Cell. 80:371-378.
13. Fawcett, T.W., J.L. Martindale, K.Z. Guyton, T. Hai, and N.J. Holbrook. 1999. Complexes containing activating transcription factor (ATF)/cAMP- responsive-element-binding protein (CREB) interact with the CCAAT/enhancer- binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem. J. 339:135-141.
14. Franceschi, R.T., and B.S. Iyer. 1992. Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells. J. Bone Miner. Res. 7:235-246.
15. Hai, T., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA. 88:3720-3724.
16. Harada, S., and G.A. Rodan. 2003. Control of osteoblast function and regulation of bone mass. Nature. 423:349-355.
17. Harding, H.P., Y. Zhang, H. Zeng, I. Novoa, P.D. Lu, M. Calfon, N. Sadri, C. Yun, B. Popko, R. Paules, et al. 2003. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell. 11:619-633.
18. Hartl, M., A.G. Bader, and K. Bister. 2003. Molecular targets of the oncogenic transcription factor jun. Curr. Cancer Drug Targets. 3:41-55.
19. Hettmann, T., K. Barton, and J.M. Leiden. 2000. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev. Biol. 222:110-123.
20. Hogan, B., R. Beddington, F. Costantini, and E. Lacy. 1994. Manipulating the Mouse Embryo. A Laboratory Manual, second edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 497 pp.
21. Jochum, W., J.P. David, C. Elliott, A. Wutz, H. Plenk Jr., K. Matsuo, and E.F. Wagner. 2000. Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat. Med. 6:980-984.
22. Karsenty, G., and E.F. Wagner. 2002. Reaching a genetic and molecular understanding of skeletal development. Dev. Cell. 2:389-406.
23. Komori, T., H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y.H. Gao, M. Inada, et al. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 89:755-764.
24. Lee, M.H., Y.J. Kim, H.J. Kim, H.D. Park, A.R. Kang, H.M. Kyung, J.H. Sung, J.M. Wozney, and H.M. Ryoo. 2003a. BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. J. Biol. Chem. 278:34387-34394.
25. Lee, M.H., T.G. Kwon, H.S. Park, J.M. Wozney, and H.M. Ryoo. 2003b. BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. Biochem. Biophys. Res. Commun. 309:689-694.
26. Liang, G., and T. Hai. 1997. Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. J. Biol. Chem. 272:24088-24095.
27. Lim, C., H. Sohn, Y. Gwack, and J. Choe. 2000. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J. Gen. Virol. 81:2645-2652.
28. Majeska, R.J., S.B. Rodan, and G.A. Rodan. 1980. Parathyroid hormoneresponsive clonal cell lines from rat osteosarcoma. Endocrinology. 107: 1494-1503.
29. Masuoka, H.C., and T.M. Townes. 2002. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 99:736-745.
30. Miyama, K., G. Yamada, T.S. Yamamoto, C. Takagi, K. Miyado, M. Sakai, N. Ueno, and H. Shibuya. 1999. A BMP-inducible gene, dlx5, regulates osteoblast differentiation and mesoderm induction. Dev. Biol. 208:123-133.
31. Moreau, A., W.V. Yotov, F.H. Glorieux, and R. St-Arnaud. 1998. Bone-specific expression of the alpha chain of the nascent polypeptide- associated complex, a coactivator potentiating c-Jun-mediated transcription. Mol. Cell. Biol. 18:1312-1321.
32. Nakashima, K., X. Zhou, G. Kunkel, Z. Zhang, J.M. Deng, R.R. Behringer, and B. de Crombrugghe. 2002. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 108:17-29.
33. Nogami, S., S. Satoh, S. Tanaka-Nakadate, K. Yoshida, M. Nakano, A. Terano, and H. Shirataki. 2004. Identification and characterization of taxilin isoforms. Biochem. Biophys. Res. Commun. 319:936-943.
34. Porter, R.M., W.R. Huckle, and A.S. Goldstein. 2003. Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells. J. Cell. Biochem. 90:13-22.
35. Quarles, L.D., D.A. Yohay, L.W. Lever, R. Caton, and R.J. Wenstrup. 1992. Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development. J. Bone Miner. Res. 7:683-692.
36. Quelo, I., M. Hurtubise, and R. St-Arnaud. 2002. alphaNAC requires an interaction with c-Jun to exert its transcriptional coactivation. Gene Expr. 10:255-262.
37. Rossert, J., H. Eberspaecher, and B. de Crombrugghe. 1995. Separate cis-acting DNA elements of the mouse pro-α1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J. Cell Biol. 129:1421-1432.
38. Sabatakos, G., N.A. Sims, J. Chen, K. Aoki, M.B. Kelz, M. Amling, Y. Bouali, K. Mukhopadhyay, K. Ford, E.J. Nestler, and R. Baron. 2000. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat. Med. 6:985-990.
39. Schinke, T., and G. Karsenty. 1999. Characterization of Osf1, an osteoblast-specific transcription factor binding to a critical cis-acting element in the mouse osteocalcin promoters. J. Biol. Chem. 274:30182-30189.
40. Sudo, H., H.A. Kodama, Y. Amagai, S. Yamamoto, and S. Kasai. 1983. In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria. J. Cell Biol. 96:191-198.
41. Tanaka, T., T. Tsujimura, K. Takeda, A. Sugihara, A. Maekawa, N. Terada, N. Yoshida, and S. Akira. 1998. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Genes Cells. 3:801-810.
42. Vallejo, M., D. Ron, C.P. Miller, and J.F. Habener. 1993. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc. Natl. Acad. Sci. USA. 90:4679-4683.
43. Yang, L., T. Tao, X. Wang, N. Du, W. Chen, S. Tao, Z. Wang, and L. Wu. 2003. Effects of dexamethasone on proliferation, differentiation and apoptosis of adult human osteoblasts in vitro. Chin. Med. J. (Engl.). 116:1357-1360.
44. Yang, X., K. Matsuda, P. Bialek, S. Jacquot, H.C. Masuoka, T. Schinke, L. Li, S. Brancorsini, P. Sassone-Corsi, T.M. Townes, et al. 2004. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 117:387-398.
45. Yotov, W.V., A. Moreau, and R. St-Arnaud. 1998. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Mol. Cell. Biol. 18:1303-1311.
46. Zelzer, E., and B.R. Olsen. 2003. The genetic basis for skeletal diseases. Nature. 423:343-348.