Cyclic nucleotide phosphodiesterases (PDEs) in human osteoblastic cells; the effect of PDE inhibition on cAMP accumulation

Cellular and Molecular Biology Letters

Volumn 10, Issue 2, 2005, Pages 305-319

  Ahlström, Mikael ^a   Pekkinen, Minna ^a   Huttunen, Minna ^a   Lamberg Allardt, Christel ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Bone; cAMP; Osteoblast; Phosphodiesterase; SaOS 2

Indexed keywords

BETA ACTIN; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; MILRINONE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE VII; PROSTAGLANDIN E2; ROLIPRAM; UNCLASSIFIED DRUG;

ARTICLE; BONE METABOLISM; CELL CULTURE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HORMONAL REGULATION; HUMAN; HUMAN CELL; OSTEOBLAST; POLYMERASE CHAIN REACTION;

EID: 22344437806     PISSN: 14258153     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Conti, M., Jin, S.L.C., Monaco, L., Repaske, D.R. and Swinnen, J.V. Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocr. Rev. 12 (1991) 218-234.
2. Conti, M., Nemoz, G., Sette, C. and Vicini, E. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr. Rev. 16 (1995) 370-389.
3. Beavo, J.A. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75 (1995) 725-748.
4. Dousa, T.P. Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cellbiology and pathophysiology of the kidney. Kidney Int. 55 (1999) 29-62.
5. Kakkar, R., Raju, R.V.S. and Sharma, R.K. Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1). Cell. Mol. Life. Sci. 55 (1999) 1164-1186.
6. Fisher, D.A., Smith, J.F., Pillar, J.S., St Denis, S.H. and Cheng J.B. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem. Biophys. Res. Commun. 246 (1998) 570-577.
7. Guipponi, M., Scott, H.S., Kudoh, J., Kawasaki, K., Shibuya, K., Shintani, A., Asakawa, S., Chen, H., Lalioti, M.D., Rossier, C., Minoshima, S., Shimizu, N. and Antonarakis, S.E. Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence. Hum. Genet. 103 (1998) 386-392.
8. Loughney, K., Snyder, P.B., Uher, L., Rosman, G.J., Ferguson, K. and Florio, V.A. Isolation and characterization of PDE10A, a novel human 3′,5′-cyclic nucleotide phosphodiesterase. Gene 234 (1999) 109-117.
9. Fawcett, L., Baxendale, R., Stacey, P., McGrouther, C., Harrow, I., Soderling, S., Hetman, J., Beavo, J.A. and Phillips, S.C. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 3702-3707.
10. Perry, M.J. and Higgs, G.A. Chemotherapeutic potential of phosphodiesterase inhibitors. Curr. Opin. Chem. Biol. 2 (1998) 472-481.
11. Fang, M.A., Kujubu, D.A. and Hahn, T.J. The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells. Endocrinology 131 (1992) 2113-2119.
12. Partridge, N.C., Bloch, S.R. and Pearman, A.T. Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression. J. Cell. Biochem. 55 (1994) 321-327.
13. Fletcher, A.E., Allan, E.H., Casley, D.J. and Martin, T.J. Atrial natriuretic factor receptors and stimulation of cyclic GMP formation in normal and malignant osteoblasts. FEBS lett. 208 (1986) 263-268.
14. Rixon, R.H., Whitfield, J.F., Gagnon, L., Isaacs, R.J., Maclean, S., Chakravarthy, B., Durkin, J.P., Neugebauer, W., Ross, V., Sung, W. and Willick, G. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase. J. Bone Miner. Res. 9 (1994) 1179-1189.
15. Whitfield, J.F., Morley, P., Ross, V., Isaacs, R.J. and Rixon, R.H. Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone (1-34). Calcif. Tissue Int. 56 (1995) 227-231.
16. Majeska, R.J. and Rodan, G.A. Alkaline phosphatase inhibition by parathyroid hormone and isoproterenol in a clonal rat osteosarcoma cell line. Possible mediation by cyclic AMP. Calcif. Tissue Int. 34 (1983) 59-66
17. Partridge, N.C., Dickson, C.A., Kopp, K., Teitelbaum, S.L., Crouch, E.C. and Kahn, A.J. Parathyroid hormone inhibits collagen synthesis at both ribonucleic acid and protein levels in rat osteogenic sarcoma cells. Mol. Endocrinol. 3 (1998) 232-239.
18. Siddhanti, R. and Quarles, D. Molecular to pharmacologic control of osteoblast proliferation and differentiation. J. Cell. Biochem. 55 (1994) 310-320.
19. Kaji, H., Sugimoto, T., Kanatani, M., Fukase, M., Kumegawa, M. and Chihara, K. Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: role of cAMP-dependent protein kinase. J. Bone Miner. Res. 11 (1996) 62-71.
20. Hikiji, H., Shin, W.S., Oida, S., Takato, T., Koizumi, T. and Toyo-oka, T. Direct action of nitric oxide on osteoblastic differentiation. FEBS lett. 410 (1997) 238-242.
21. Hagiwara, H., Inoue, A., Yamaguchi, A., Yokose, S., Furuya, M., Tanaka, S. and Hirose, S. cGMP produced in response to ANP and CNP regulates proliferation and differentiation of osteoblastic cells. Am. J. Physiol. 270 (1996) C1311-C1318.
22. Inoue, A., Hiruma, Y., Hirose, S., Yamaguchi, A., Furuya, M., Tanaka, S. and Hagiwara, M. Stimulation by C-type natriuretic peptide of the differentiation of clonal osteoblastic MC3T3-E1 cells. Biochem. Biophys. Res. Commun. 221 (1996) 703-707.
23. Mancini, L. and Brandi, L. The european calcified tissue society (2000) http://www.ectsoc.org/reviews/001_bran.htm.
24. Nashida, T., Matsumoto, H., Imai, A. and Shimomura, H. Effect of cyclic GMP produced by natriuretic peptides on osteoblast-like MC3T3-E1 cells. Biochem. Mol. Biol. Int. 40 (1996) 1243-1251.
25. Suda, M., Tanaka, K., Fukushima, M., Natsui, K., Yasoda, A., Komatsu, Y., Ogawa, Y., Itoh, H. and Nakao, K. C-type natriuretic peptide as an autocrine/paracrine regulator of osteoblast. Biochem. Biophys. Res. Commun. 223 (1996) 1-6.
26. Suda, M., Komatsu, Y., Tanaka, K., Yasoda, A., Sakuma, Y., Tamura, N., Ogawa, Y. and Nakao K. C-Type natriuretic peptide/guanylate cyclase B system in rat osteogenic ROB-C26 cells and its down-regulation by dexamethazone. Calcif. Tissue Int. 65 (1999) 472-478.
27. Ahlström, M. and Lamberg-Allardt, C. Rapid protein kinase A-mediated activation of cyclic AMP-phosphodiesterase by parathyroid hormone in UMR-106 osteoblast-like cells. J. Bone Miner. Res. 12 (1997) 172-178.
28. Ahlström, M. and Lamberg-Allardt, C. Regulation of adenosine 3′,5′-cyclic monophosphate (cAMP) accumulation in UMR. 106 osteoblast-like cells: role of cAMP-phosphodiesterase and cAMP efflux. Biochem. Pharmacol. 58 (1999) 1335-1340.
29. Frandsen, E.K. and Krishna, G. A. A simple ultrasensitive method for the assay of cyclic AMP and cyclic GMP in tissues. Life Sci. 18 (1976) 529-542.
30. Sakakibara, H., Conti, M. and Weiner, R.I. Role of phosphodiesterases in the regulation of gonadotropin- releasing hormone secretion in GT1 cells. Neuroendocrinology 68 (1998) 365-373.
31. Ekholm, D., Hemmer, B., Gao, G., Vergelli, M., Martin, R. and Manganiello, V. Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein. J. Immunol. 159 (1997) 1520-1529.
32. Leroy, M-J., Méhats, C., Duc-Goiran, P., Tanguy, G., Robert, B., Dallot, E., Mignot, T.M., Grangé, G. and Ferré, F. Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium. Cell. Signal. 11 (1999) 31-37.
33. Torphy, T.J., Zhou, H.L., Foley, J.J., Sarau, H.M., Manning, C.D. and Barnette, M.S. Salbutamol up-regulates PDE4 activity and induces a heterologous desensitization of U937 cells to prostaglandin E2. Implications for the therapeutic use of beta-adrenoceptor agonists. J. Biol. Chem. 270 (1995) 23598-23604.
34. Erdogan, S. and Houslay, M.D. Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel PDE4A splice variant. Biochem. J. 321 (1997) 165-175.
35. Giembycz, M.A., Corrigan, C.J., Seybold, J., Newton, R. and Barnes, P.J. Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br. J. Pharmacol. 118 (1996) 1945-1958.
36. Kostic, M.M., Erdogan, S., Rena, G., Borchert, G., Hoch, B., Bartel, S., Scotland, G., Huston, E., Houslay, M.D. and Krause, E-G. Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart. J. Mol. Cell. Cardiol. 29 (1997) 3135-3146.
37. Michaeli, T., Bloom, T.J., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rogers, L., Beavo, J.A. and Wigler, M. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J. Biol. Chem. 268 (1993) 12925-12932.
38. Hetman, J.M., Soderling, S.H., Glavas, N.A. and Beavo, J.A. Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 472-476.
39. Sasaki, T., Kotera, J., Yuasa, K. and Omori, K. Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem. Biophys. Res. Commun. 271 (2000) 575-583.
40. Gardner, C., Robas, N., Cawkill, D. and Fidock, M. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem. Biophys. Res. Commun. 272 (2000) 186-192.
41. Sonnenburg, W.K., Seger, D. and Beavo, J.A. Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J. Biol. Chem. 268 (1993) 645-652.
42. Jiang, X., Li, J., Paskind, M. and Epstein, P.M. Inhibition of calmodulin dependent phosphodiesterase induces apoptosis in human leukemic cells. J. Biol. Chem. 93 (1996) 11236-11241.
43. Loughney, K., Martins, T.J., Harris, E.A., Sadhu, K., Hicks, J.B., Sonnenburg, W.K., Beavo, J.A. and Ferguson, K. Isolation and characterization of cDNAs corresponding to two human calcium-calmodulin regulated, 3′,5′-cyclic nucleotide phosphodiesterases. J. Biol. Chem. 271 (1996) 796-806.
44. Wakabayashi S., Tsutsumimoto T., Kawasaki S., Kinoshita T., Horiuchi H. and Takaoka K. Involvement of phosphodiesterase isozymes in osteoblastic differentiation. J. Bone Miner. Res. 17 (2002) 249-256.
45. Miyamoto, K., Waki, Y., Horita, T., Kasugai, S. and Ohya, K. Reduction of bone loss by denbufylline, an inhibitor of phosphodiesterase 4. Biochem. Pharmacol. 54 (1997) 613-617.
46. Waki, Y., Horita, T., Miyamoto, K., Ohya, K. and Kasugai, S. Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models. Jpn. J. Pharmacol. 79 (1999) 477-483.
47. Kinoshita, T., Kobayashi, S., Ebara, S., Yoshimura, Y., Horiuchi T., Tsutsumimoto, T., Itoh, H., Wakabayashi, S. and Takaoka, K. Phosphodiesterase inhibitors, pentoxifylline and rolipram, increase bone mass mainly by promoting bone formation in normal mice. Bone 27 (2000) 811-817.