Functional genomics in drug target research

Chinese Pharmacological Bulletin

Volumn 21, Issue 3, 2005, Pages 266-268

  Wang, Yu ^a   Wang, Hai ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Biology technologies; Drug discovery; Drug target

Indexed keywords

CYCLOSPORIN A; DNA; MESSENGER RNA; RAPAMYCIN; RIBONUCLEASE H; RNA; TACROLIMUS;

ARTICLE; DRUG RESEARCH; DRUG TARGETING; FUNCTIONAL GENOMICS; HUMAN; HUMAN GENOME; MOLECULAR BIOLOGY; PHARMACOGENOMICS; TECHNOLOGY;

EID: 22344434266     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. homas Reiss. Drug discovery of the future: the implications of human genome project[J]. TRENDS in Biotechnology, 2001, 19 (12):496-9.
2. Drews J. Drug discovery: A historical perspective[J]. Science, 2000,287(5460):1960-4.
3. Drews J. Genomics sciences and the medicine of tomorrow[J]. Nat Biotechnol, 1996,14(11):1516-8.
4. Hopkins AL, Groom CR. The druggable genome[J]. Nat Rev Drug Discov, 2002,1(9):727-30.
5. Lindsay MA. Target discovery[J]. Nat Rev Drug Discov, 2003,2 (10):831-7.
6. Xinang CC, Chen Y. cDNA microarray technology and its applications[J]. Biotechnol Adv, 2000,18(1):35-46.
7. Hong NA, Kay SA, Glynne RJ. Using mouse forward genetics to define novel target space[J]. Targets, 2002,1:130-8.
8. Dean NM. Functional genomics and target validation approaches using antisense oligonucleotide technology[J]. Curr Opin Biotechnol, 2001,12(6):622-5.
9. Couzin J. Small RNAs make big splah[J]. Science, 2002,298 (5602):2296-97.
10. Hannon GJ. RNA interference[J]. Nature, 2002,418(6894):244 -51.
11. Zambrowicz BP, Sands AT. Knockouts model the 100-best-selling drugs-will they model the next 100[J]. Nat Rev Drug Discov, 2003,2(1):38-51.
12. Walke DW. in vivo drug target discovery: Identifying the best targets from the genome[J]. Curr Opin Biotechnol, 2001,12(6):626 -31.
13. Stockwell BR. Chemical genetics: ligand-based discovery of gene function[J]. Nat Rev Genet, 2000,1(2):116-25.
14. Falb D, Jindal S. Chemical genomics: bridging the gap between the proteome and therapeutics[J]. Current Opinion in Drug Discovery and Development, 2002,5(4):532-9.