Disease models of breast cancer

Drug Discovery Today: Disease Models

Volumn 1, Issue 1, 2004, Pages 9-16

  Gupta, Piyush B ^a   Kuperwasser, Charlotte ^b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRASTUZUMAB;

BONE METASTASIS; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER; CANCER GROWTH; CANCER INHIBITION; CELL CULTURE; COMPUTER MODEL; DISEASE MODEL; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; MICROENVIRONMENT; NONHUMAN; ONCOGENE; ONCOGENE NEU; PHENOTYPE; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; XENOGRAFT;

EID: 22244451122     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2004.05.001     Document Type: Review

References (20)

1. Ghafoor, A. et al. (2004) American Cancer Society Breast Cancer Facts & Figures. Breast Cancers Facts Figures 1-56
2. Barcellos-Hoff, M. et al. (1989) Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development 105, 223-235
3. Debnath, J. et al. (2002) The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29-40
4. Muthuswamy, S.K. et al. (2001) ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat. Cell Biol. 3, 785-792
5. Wang, F. et al. (2002) Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J. Natl. Cancer Inst. 94, 1494-1503
6. Guy, C.T. et al. (1992) Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc. Natl. Acad. Sci. USA 89, 10578-10582
7. Muraoka, R.S. et al. (2003) Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol. Cell Biol. 23, 8691-8703
8. Siegel, P.M. et al. (2003) Transforming growth factor beta signalling impairs neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc. Natl. Acad Sci. USA 100, 8430-8435
9. Kuperwasser, C. et al. (2000) Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice: a model for Li-fraumeni syndrome. Am. J. Pathol. 157, 2151-2159
10. Jerry, D.J. et al. (2000) A mammary-specific model demonstrates the role of p53 tumor suppressor gene in tumor development. Oncogene. 19
11. Medina, D. et al. (2003) Hormone dependence in premalignant mammary progression. Cancer Res. 63, 1067-1072
12. Lin, S-C.J. et al. (2004) Somatic mutations of p53 lead to ERa-positive and negative mouse mammary tumors with high rates of metastasis. Cancer Res. 64, 3525-3532
13. Xu, X. et al. (1999) Conditional mutation of BRCA1 in mammary epithelial cells results in blunted ductal morphogenesis and tumor formation. Nat. Genet. 22, 37-43
14. Cressman, V.L. et al. (1999) Mammary tumor formation in p53- and BRCA1-deficient mice. Cell Growth Differentiation. 10, 1-10
15. Berton, T.R. et al. (2003) Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues. Oncogene 22, 5415-5426
16. Ethier, S.P. et al. (2000) Isolation and culture of human breast cancer cells from primary tumors and metastases. In Methods in Mammary Gland Biology and Breast Cancer (Ip, M.M. and Asch, B.B., eds.), pp. 195-208, Kluwer Academic/Plenum Publishers
17. Olumi, A.F. et al. (1998) A novel coculture technique demonstrates that normal human prostatic fibroblasts contribute to tumor formation of LNCaP cells by retarding cell death. Cancer Res. 58, 4525-4530
18. Parmar, H. et al. (2002) A novel method for growing human breast epithelium in vivo using mouse and human mammary fibroblasts. Endocrinology 143, 4886-4896
19. Kuperwasser, C. et al. (2004) Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl. Acad. Sci. USA 101, 4966-4971
20. Kang, Y. et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 3, 537-549