Anthrax toxin entry into polarized epithelial cells

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 3026-3030

  Beauregard, Kathryn E ^a   Wimer Mackin, Susan ^a,b   Collier, R John ^a,c   Lencer, Wayne I ^a,b,c  

^a Department of Microbiology ^*  (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; CYCLIC AMP;

ARTICLE; BACILLUS ANTHRACIS; CELLULAR DISTRIBUTION; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT;

EID: 0033060447     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.3026-3030.1999     Document Type: Article

References (41)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seldman, J. A. Smith, and K. Struhl (ed.). 1993. Current protocols in molecular biology. John Wiley and Sons, Inc., New York, N.Y.
2. Ballard, J. D., A. M. Doling, K. Beauregard, R. J. Collier, and M. N. Starnbach. 1998. Anthrax toxin-mediated delivery in vivo and in vitro of a cytotoxic T-lymphocyte epitope from ovalbumin. Infect. Immun. 66:615-619.
3. Barrett, K. E. 1993. Positive and negative regulation of chloride secretion in T84 cells. Am. J. Physiol. 265:C859-C868.
4. Benson, E. L. P. D. Hujnh, A. Finkelstein, and R. J. Collier. 1998. Identification of residues lining the anthrax protective antigen channel. Biochemistry 37:3941-3948.
5. Cartwright, C. A., J. A. McRoberts, K. G. Mandel, and K. Dharmsathaphorn. 1985. Synergistic action of cyclic adenosine monophosphate- and calcium-mediated chloride section in a colonic epithelial cell line. J. Clin. Invest. 76:1837-1842.
6. - secreting epithelial cells. Proc. Natl. Acad. Sci. USA 87:4956-4960.
7. Dharmsathaphorn, K., and J. L. Madara. 1990. Established intestinal cell lines as model systems for electrolyte transport studies. Methods Enzymol. 192:354-389.
8. Dharmsathaphorn, K., K. G. Mandel, H. Masui, and J. A. McRoberts. 1985. Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line. J. Clin. Invest. 75:462-471.
9. Dharmsathaphorn, K., J. A. McRoberts, K. G. Mandel, L. D. Tisdale, and H. Masui. 1984. A human colonie tumor cell line that maintains vectorial electrolyte transport. Am. J. Physiol. 246:G204-G208.
10. Escuyer, V., and R. J. Collier. 1991. Anthrax protective antigen interacts with a specific receptor on the surface of CHO-K1 cells. Infect. Immun. 59:3381-3386.
11. Friedlander, A. M. 1986. Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process. J. Biol. Chem. 261:7123-7126.
12. Gordon, V. M., K. R. Klimpel, N. Arora, M. A. Henderson, and S. H. Leppla. 1995. Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases. Infect. Immun. 63:82-87.
13. Gordon, V. M., A. Rehemtulla, and S. H. Leppla. 1997. A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen. Infect. Immun. 65:3370-3375.
14. Gordon, V. M., J. William W. Young, S. M. Lechler, M. C. Gray, S. H. Leppla, and E. L. Hewlett. 1989. Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. J. Biol. Chem. 264:14792-14796.
15. Iliev, I. G., and A. A. Marino. 1993. Potassium channels in epithelial cells. Cell. Mol. Biol. Res. 39:601-611.
16. Klimpel, K. R., S. S. Molloy, G. Thomas, and S. H. Leppla. 1992. Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin. Proc. Natl. Acad. Sci. USA 89:10277-10281.
17. Lencer, W. I., C. Constable, S. Moe, M. G. Jobling, H. M. Webb, S. Ruston, J. L. Madara, T. R. Hirst, and R. K. Holmes. 1995. Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL. J. Cell Biol. 131:951-962.
18. Lencer, W. I., J. B. de Almeida, S. Moe, J. L. Stow, D. A. Ausiello, and J. L. Madara. 1993. Entry of cholera toxin into polarized human intestinal epithelial cells. J. Clin. Invest. 92:2941-2951.
19. Lencer, W. I., C. Delp, M. R. Neutra, and J. L. Madara. 1992. Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic. J. Cell Biol. 117:1197-1209.
20. Lencer, W. I., S. Moe, P. A. Rufo, and J. L. Madara. 1995. Transcytosis of cholera toxin subunits across model human intestinal epithelia. Proc. Natl. Acad. Sci. USA 02:10094-10098.
21. Lencer, W. I., G. Strohmeier, S. Moe, S. L. Carlson, C. T. Constable, and J. L. Madara. 1995. Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification. Am. J. Physiol. 269: G548-G557.
22. Leppla, S. H. 1982. Anthrax toxin edema factor: a bacterial adenylate cyclase that increase cAMP concentrations in eukaryotic cells. Proc. Natl. Acad. Sci. USA 79:3162-3166.
23. Leppla, S. H. 1984. Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17:189-198.
24. Lomax, R. B., G. Warhurst, and G. I. Sandle. 1996. Characteristics of two basolateral potassium channel populations in human colonic crypts. Gut 38:243-247.
25. Madara, J. L., S. Colgan, A. Nusrat, C. Delp, and C. Parkos. 1992. A simple approach to measurement of electrical parameters of cultured epithelial monolayers: use in assessing neutrophil-epithelial interactions. J. Tissure Cult. Methods 14:209-216.
26. Majoul, I. V., P. I. H. Bastiaens, and H.-D. Soling. 1996. Transport of an external Lys-Asp-Glu-Leu (KDEL) protein from the plasma membrane to the endoplasmic reticulum: studies with cholera toxin in Vero cells. J. Cell Biol. 133:777-789.
27. - transport pathway in the apical membrane of a human colonie epithelial cell line. J. Biol. Chem. 261:704-712.
28. Matter, K., and I. Mellman. 1994. Mechanisms of cell polarity: sorting and transport in epithelial cells. Curr. Opin. Cell Biol. 6:545-554.
29. Menard, A., K. Altendorf, D. Breves, M. Mock, and C. Montecucco. 1996. The vacuolar ATPase proton pump is required for the cytotoxicity of Bacillus anlhracis lethal toxin. FEBS Lett. 386:161-164.
30. Milne, J. C., and R. J. Collier. 1993. pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen. Mol. Microbiol. 10:647-653.
31. Milne, J. C., D. Furlong, P. C. Hanna, J. S. Wall, and R. J. Collier. 1994. Anthrax protective antigen forms oligomers during intoxication of mammalian cells. J. Biol. Chem. 269:20607-20612.
32. Moss, J., and M. Vaughan. 1979. Activation of adenylate cyclase by choleragen. Annu. Rev. Biochem. 481:581-600.
33. Novak, J. M., M.-P. Stein, S. F. Little, S. H. Leppla, and A. M. Friedlander. 1992. Functional characterization of protease-treated Bacillus anthracis protective antigen. J. Biol. Chem. 267:17186-17193.
34. Orlandi, P. A., and P. H. Fishman. 1998. Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains. J. Cell Biol. 141:905-915.
35. Petosa, C., R. J. Collier, K. R Klimpel, S. H. Leppla, and R. C. Liddington. 1997. Crystal structure of the anthrax toxin protective antigen. Nature 385: 833-838.
36. - secretion by polarized monolayers of human colonic epithelial cells. J. Clin. Invest. 98:2066-2075.
37. Simons, K. 1995. Biogenesis of epithelial cell surface polarity. Harvey Lect. 89:125-146.
38. Singh, Y., V. K. Chaudhary, and S. H. Leppla. 1989. A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo. J. Biol. Chem. 264:19103-19107.
39. 315, in anthrax toxin protective antigen is required for translocation of lethal factor. J. Biol. Chem. 269:29039-29046.
40. Strohmeier, G. R., W. I. Lencer, T. W. Patapoff, L. F. Thompson, S. L. Carlson, S. J. Moe, D. K. Carnes, R. J. Mrsny, and J. L. Madara. 1997. Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. J. Clin. Invest. 99:2588-2601.
41. Wolf, A. A., M. G. Jobling, S. Wimer-Mackin, M. Ferguson-Maltzman, J. L. Madara, R. K. Holmes, and W. I. Lencer. 1998. Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. J. Cell Biol. 141:917-927.