The α 2δ subunit of the tension-dependent calcium channel;Die α 2δ-untereinheit der spannungsabhängigen kalziumkanäle: Ein neues pharmakologisches ziel in der psychiatrie und neurologie

Nervenarzt

Volumn 76, Issue 7, 2005, Pages 888-892

  Wedekind, D ^a   Bandelow, B ^a   Degner, D ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

2 Subunit; AMPA heteroreceptors; Calcium channel; Gabapentin; Glutamate; Neurologic indications; Pregabalin; Psychiatric indications

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; GABAPENTIN; GLUTAMIC ACID; PREGABALIN; SUBSTANCE P; PROTEIN SUBUNIT;

ALPHA CHAIN; AMINO ACID TRANSPORT; CALCIUM TRANSPORT; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; NERVE CELL; NEUROPATHIC PAIN; REVIEW; ANIMAL; BRAIN; DRUG EFFECT; MENTAL DISEASE; METABOLISM; NEUROLOGIC DISEASE; PATHOPHYSIOLOGY;

ANIMALS; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; HUMANS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; PROTEIN SUBUNITS;

EID: 22144499267     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00115-005-1940-7     Document Type: Review

References (34)

1. Arikkoth J, Campbell KP (2003) Auxiliary subunits: essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 13:298-307
2. Arroyo S, Anhut H, Kugler AR et al. (2004) Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 45:20-27
3. Brust PF, Simerson S, McCue AF et al. (1993) Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. Neuropharmacology 32:1089-1102
4. Dooley DJ, Donovan CM, Pugsley TA (2000) Stimulus-dependent modulation of [(3(H] norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther 295:1086-1093
5. Dworkin RH, Corbin AE, Young JPJr et al. (2003) Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 60:1274-1283
6. Feltner DE, Pollack MH, Davidson JRT (2000) A placebo-controlled study of pregabalin in the treatment of social phobia. Abstract, Anxiety Disorders Of America's 20th Annual Conference, Washington
7. Feltner DE, Crockatt JG, Dubovsky SJ et al. (2003) A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 23:240-249
8. Fink K, Dooley DJ, Meder WP et al. (2002) Inhibition of neuronal Ca (2+) influx by gabapentin and pregabalin in the human neocortex. Neuropsychopharmacology 42:229-236
9. Frampton JE, Foster RH (2005) Pregabalin: in the treatment of postherpetic neuralgia. Drugs 65:111-118
10. Frampton JE, Scott LJ (2004) Pregabalin: in the treatment of painful diabetic peripheral neuropathy. Drugs 64:2813-2820
11. French JA, Kugler AR, Robbins JL et al. (2003) Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 60:1631-1637
12. Gee NS, Brown JP, Dissanayake VUK et al. (1996) The novel anticonvulsant drug, gabapentin (Neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem 271:5768-5776
13. Hofman F, Biel M, Flockerzi V (1994) Molecular basis for Ca (2+) channel diversity. Annu Rev Neurosci 17:399-418
14. Isom LL, De Jongh KS, Caterall WA (1994) Auxiliary subunits of voltage-gated ion channels. Neuron 12:1183-1194
15. Klugbauer N, Lacinova L, Marais E et al. (1999) Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci 19:684-691
16. Lauria-Horner BA, Pohl RB (2003) Pregabalin: a new anxiolytic. Expert Opin Investig Drugs 12:663-672
17. Lesser H, Sharma U, LaMoreaux L et al. (2004) Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology 63:2104-2110
18. 3H]-glutamate from rat caudal trigeminal nucleus slices. Soc Neurosci 26:722-729
19. Maneuf YP, Hughes J, McKnight AT (2001) Gabapentin inhibits substance P-facilitated K(+)-evoked release of [(3)H] glutamate from rat caudal trigeminal nucleus slices. Pain 93:191-196
20. Martin DJ, McClelland D, Herd MB et al. (2002) Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression. Neuropharmacology 42:353-366
21. McGivern JG, McDonough SI (2004) Voltage-gated calcium channels as targets for the treatment of chronic pain. Curr Drug Target CNS Neurol Disord 3:457-478
22. Pande AC, Davidson JR, Jefferson JW et al. (1999) Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 19:341-348
23. Pande AC, Pollack MH, Crockatt J et al. (2000) Placebo-controlled study of gabapentin treatment of panic disorder. J Clin Psychopharmacol 20:467-471
24. Pande AC, Crockatt JG, Feltner DE et al. (2003) Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 160:533-540
25. Pande AC, Feltner DE, Jefferson JW et al. (2004) Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study. J Clin Psychopharmacol 24:141-149
26. Reichling DB, Levine JD (1999) The primary afferent nociceptor as a pattern generator. Pain 6(Suppl):103-109
27. Rosenstock J, Tuchman M, LaMoreaux L et al. (2004) Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 110:628-638
28. Sieghart W (2003) Benzodiazepines, benzodiazepine receptors, and endogeneous ligands. In: Kasper S, den Boer JA, Ad Sitsen JM (eds) Handbook of depression and anxiety. Dekker, New York, pp 415-442
29. Su T, Gong CH, Hang J et al. (2000) Human α2δ2 subunit of calcium channel: a novel gabapentin binding protein in brain. Soc Neurosci 26:40.20
30. Sutton KG, Martin DJ, Pinnock RD et al. (2002) Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurons. Br J Pharmacol 135:257-265
31. Taylor CP, Vartanian MG, Yuen PW et al. (1993) Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labelled by tritiated gabapentin. Epilepsy Res 14:11-15
32. Thurlow RJ, Brown JP, Gee NS et al. (1993) [3H] gabapentin may label a system-L-like neutral amino acid carrier in brain. Eur J Pharmacol 247:341-345
33. Walker D, De Waard M (1998) Subunit interaction sites in voltage-dependent Ca(2+) channels: role in channel function. Trends Neurosci 21:148-154
34. Williams ME, Feldman DH, McCue AF et al. (1992) Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron 8:71-84