Influence of p53 status on the HSV-Tk/GCV-induced bystander effect in a panel of human ovarian carcinoma cell lines

Oncology Research

Volumn 15, Issue 3, 2005, Pages 151-159

  Van Dillen, Ingrid J ^a   Mulder, Nanno H ^a   Sluiter, Wim J ^a   Meijer, Coby ^a   De Jong, Steven ^a   Loncarek, Jadranka ^b   Mesnil, Marc ^c   De Vries, Erik F J ^a   Vaalburg, Willem ^a   Hospers, Geke A P ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c UNIVERSITÉ DE POITIERS   (France)

Author keywords

Bystander effect; Ganciclovir; Gap junctional intercellular communication; Herpes simplex virus thymidine kinase; Multidrug resistance; p53

Indexed keywords

CONNEXIN 43; GANCICLOVIR; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; PROTEIN P53; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CELL COMMUNICATION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DRUG SENSITIVITY; GAP JUNCTION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL; RAT;

EID: 22144494177     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/096504005776367942     Document Type: Article

References (32)

1. Moolten, F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46:5276-5281; 1986.
2. Tomicic, M. T.; Bey, E.; Wutzler, P.; Thust, R.; Kaina, B. Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir. Mutat. Res. 505:1-11; 2002.
3. Mesnil, M.; Yamasaki, H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication. Cancer Res. 60:3989-3999; 2000.
4. Tanaka, T.; Yamasaki, H.; Mesnil, M. Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/ GCV bystander effect in vitro. Int. J. Cancer 91:538-542; 2001.
5. Robe, P. A.; Princen, F.; Martin, D.; Malgrange, B.; Stevenaert, A.; Moonen, G.; Gielen, J.; Merville, M.; Bours, V. Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system: Effects of dibutyryl adenosine 3′,5′-cyclic monophosphate, alpha-glycyrrhetinic acid, and cytosine arabinoside. Biochem. Pharmacol. 60:241-249; 2000.
6. Adachi, M.; Sampath, J.; Lan, L. B.; Sun, D.; Hargrove, P.; Flatley, R. M.; Tatum, A.; Ziegelmeier, M. Z.; Wezeman, M.; Matherly, L. H.; Drake, R. R.; Schuetz, J. D. Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. J. Biol. Chem. 277: 38998-39004; 2002.
7. Schuetz, J. D.; Connelly, F; Sun, D.; Paibir, S. G.; Flynn, P. M.; Srinivas, R. V.; Kumar, A.; Fridland, A. MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs. Nat. Med. 5:1048-1051; 1999.
8. Jedlitschky, G.; Burchell, B.; Keppler, D. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J. Biol. Chem. 275:30069-30074; 2000.
9. Lee, K.; Klein-Szanto, A. J. P.; Kruh, G. D. Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells. J. Natl. Cancer Inst. 92:1934-1940; 2000.
10. Wijnholds, J.; Mol, C. A. A. M.; van Deemter, L.; de Haas, M.; Scheffer, G. L.; Baas, F.; Beijnen, J. H.; Scheper, R. J.; Hatse, S.; De Clercq, E.; Balzarini, J.; Borst, P. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc. Natl. Acad. Sci. USA 97:7476-7481; 2000.
11. Ryan, K. M.; Phillips, A. C.; Vousden, K. H. Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell Biol. 13:332-337; 2001.
12. Wang, Q.; Beck, W. T. Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53. Cancer Res. 58:5762-5769; 1998.
13. Fukushima, Y.; Oshika, Y.; Tokunaga, T.; Hatanaka, H.; Tomisawa, M.; Kawai, K.; Ozeki, Y.; Tsuchida, T.; Kijima, H.; Yamazaki, H.; Ueyama, Y.; Tamaoki, N.; Miura, S.; Nakamura, M. Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer. Eur. J. Cancer 35:935-938; 1999.
14. Hayashi, T.; Matesic, D. F.; Nomata, K.; Kang, K. S.; Chang, C. C.; Trosko, J. E. Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid. Cancer Lett. 112:103-111; 1997.
15. Hospers, G. A. P.; Calogero, A.; van Waarde, A.; Doze, P.; Vaalburg, W.; Mulder, N. H.; de Vries, E. F. J. Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography. Cancer Res. 60:1488-1491; 2000.
16. Sleijfer, S.; Le, T. K. P.; de Jong, S.; Timmer-Bosscha, H.; Withoff, S.; Mulder, N. H. Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53. J. Immunother. 22:48-53; 1999.
17. Hamel, W.; Magnelli, L.; Chiarugi, V. P.; Israel, M. A. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res. 56: 2697-2702; 1996.
18. Andrade-Rozental, A. F.; Rozental, R.; Hopperstad, M. G.; Wu, J. K.; Vrionis, F. D.; Spray, D. C. Gap junctions: The "kiss of death" and the "kiss of life". Brain Res. Brain Res. Rev. 32:308-315; 2000.
19. Vile, R. G.; Castleden, S.; Marshall, J.; Camplejohn, R.; Upton, C.; Chong, H. Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int. J. Cancer 71:267-274; 1997.
20. Beltinger, C.; Fulda, S.; Kammertoens, T.; Meyer, E.; Uckert, W.; Debatin, K. M. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases. Proc. Natl. Acad. Sci. USA 96:8699-8704; 1999.
21. Glaser, T.; Castro, M. G.; Lowenstein, P. R.; Weller, M. Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells. Gene Ther. 8:469-476; 2001.
22. Fels, C.; Schafer, C.; Huppe, B.; Bahn, H.; Heidecke, V.; Kramm, C. M.; Lautenschlager, C.; Rainov, N. G. Bcl-2 expression in higher-grade human glioma: A clinical and experimental study. J. Neurooncol. 48:207-216; 2000.
23. Beltinger, C.; Fulda, S.; Kammertoens, T.; Uckert, W.; Debatin, K. M. Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis. Cancer Res. 60:3212-3217; 2000.
24. Beltinger, C.; Fulda, S.; Walczak, H.; Debatin, K. M. TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells. Cancer Gene Ther. 9:372-381; 2002.
25. Lai, L.; Tan, T. M. C. Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem. J. 361:497-503; 2002.
26. Bahr, O.; Wick, W.; Weller, M. Modulation of MDR/ MRP by wild-type and mutant p53. J. Clin. Invest. 107: 643-646; 2001.
27. Ozog, M. A.; Bechberger, J. F.; Naus, C. C. Ciliary neurotrophic factor (CNTF) in combination with its soluble receptor (CNTFRalpha) increases connexin43 expression and suppresses growth of C6 glioma cells. Cancer Res. 62:3544-3548; 2002.
28. Hanna, E. A.; Umhauer, S.; Roshong, S. L.; Piechocki, M. P.; Fernstrom, M. J.; Fanning, J. D.; Ruch, R. J. Gap junctional intercellular communication and connexin43 expression in human ovarian surface epithelial cells and ovarian carcinomas in vivo and in vitro. Carcinogenesis 20:1369-1373; 1999.
29. Robe, P. A.; Rogister, B.; Merville, M. P.; Bours, V. Growth regulation of astrocytes and C6 cells by TGF-beta1: Correlation with gap junctions. Neuroreport 11: 2837-2841; 2000.
30. Sai, K.; Kang, K. S.; Hirose, A.; Hasegawa, R.; Trosko, J. E.; Inoue, T. Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: Relation to down-regulation of gap junctional intercellular communication. Cancer Lett. 173:163-174; 2001.
31. Asklund, T.; Appelskog, I. B.; Ammerpohl, O.; Langmoen, I. A.; Dilber, M. S.; Aints, A.; Ekstrom, T. J.; Almqvist, P. M. Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Exp. Cell Res. 284: 183-193; 2003.
32. Krysko, D. V.; Mussche, S.; Leybaert, L.; D'Herde, K. Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells. J. Histochem. Cytochem. 52:1199-1207; 2004.