Effects of grapefruit juice on the pharmacokinetics of sildenafil

Clinical Pharmacology and Therapeutics

Volumn 71, Issue 1, 2002, Pages 21-29

  Jetter, Alexander ^a   Kinzig Schippers, Martina ^a,b   Walchner Bonjean, Monika ^a,b   Hering, Ursula ^a,b   Bulitta, Jürgen ^a,b   Schreiner, Philipp ^a,b   Sörgel, Fritz ^a,b   Fuhr, Uwe ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b Institute for Biomedical and Pharmaceuticl Research   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DRUG METABOLITE; N NORSILDENAFIL; SILDENAFIL; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; ENZYME INHIBITION; FIRST PASS EFFECT; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HEADACHE; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; NOSE OBSTRUCTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VERTIGO;

ADULT; AREA UNDER CURVE; BEVERAGES; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; BLOOD PRESSURE; CALIBRATION; CITRUS; CYTOCHROME P-450 ENZYME SYSTEM; FOOD-DRUG INTERACTIONS; HEART RATE; HUMANS; MALE; MIXED FUNCTION OXYGENASES; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; QUALITY CONTROL;

EID: 0036159434     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2002.121236     Document Type: Article

References (32)

1. In vitro biotransformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions
2. Use of sildenafil (Viagra) in patients with cardiovascular disease
3. Klinisch-pharmakologisches Profil: Sildenafilzitrat (Viagra)
4. Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man
5. Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil
6. Sildenafil citrate: A therapeutic update
7. Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir
8. Interaction of sildenafil and indinavir when co-administered to HIV-positive patients
9. Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression
10. Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance
11. Erythromycin-felodipine interaction: Magnitude, mechanism, and comparison with grapefruit juice
12. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin
13. Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins
14. Specific CYP3A4 inhibitors in grapefruit juice: Furocoumarin dimers as components of drug interaction
15. Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins
16. Inhibition selectivity of grapefruit juice components on human cytochromes
17. Grapefruit juice (GFJ) inhibits hepatic and intestinal CYP3A4 dose-dependently
18. Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity
19. Sample size determination for bioequivalence assessment by means of confidence intervals
20. Lack of pharmacokinetic interaction as an equivalence problem
21. Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects
22. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice
23. Krähenbühl S Interaction between grapefruit juice and midazolam in humans
24. Influence of grapefruit juice on cisapride pharmacokinetics
25. Determination of sildenafil citrate in plasma by high-performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate
26. Pharmacokinetics of sildenafil (Viagra®), a selective cGMP PDE5 inhibitor, after single oral doses in fasted and fed healthy volunteers
27. Sildenafil. A review of its use in erectile dysfunction
28. Amounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction
29. Coumarins and psoralens in grapefruit peel oil