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Volumn 125, Issue 1, 2005, Pages 72-82

Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen - The role of tissue transglutaminase

Author keywords

Apoptosis; Cicatrix; Collagen; Transglutaminase II; Wound healing

Indexed keywords

COLLAGEN GEL; COLLAGENASE; DOXORUBICIN; GELATINASE A; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PUTRESCINE;

EID: 22144472964     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23771.x     Document Type: Article
Times cited : (76)

References (48)
  • 1
    • 0035727356 scopus 로고    scopus 로고
    • Detection of apoptosis in keloids and a comparative study on apoptosis between keloids, hypertrophic scars, normal healed flat scars, and dermatofibroma
    • Akasaka Y, Fujita K, Ishikawa Y, et al: Detection of apoptosis in keloids and a comparative study on apoptosis between keloids, hypertrophic scars, normal healed flat scars, and dermatofibroma. Wound Repair Regen 9:501-506, 2001
    • (2001) Wound Repair Regen , vol.9 , pp. 501-506
    • Akasaka, Y.1    Fujita, K.2    Ishikawa, Y.3
  • 2
    • 0034028753 scopus 로고    scopus 로고
    • Enhanced expression of caspase-3 in hypertrophic scars and keloid: Induction of caspase-3 and apoptosis in keloid fibroblasts in vitro
    • Akasaka Y, Ishikawa Y, Ono I, et al: Enhanced expression of caspase-3 in hypertrophic scars and keloid: Induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. Lab Invest 80:345-357, 2000
    • (2000) Lab Invest , vol.80 , pp. 345-357
    • Akasaka, Y.1    Ishikawa, Y.2    Ono, I.3
  • 3
    • 0034695929 scopus 로고    scopus 로고
    • Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
    • Akimov SS, Krylov D, Fleischman LF, Belkin AM: Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin. J Cell Biol 148: 825-838, 2000
    • (2000) J Cell Biol , vol.148 , pp. 825-838
    • Akimov, S.S.1    Krylov, D.2    Fleischman, L.F.3    Belkin, A.M.4
  • 4
    • 0001680837 scopus 로고
    • Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes
    • Bornstein MB: Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes. Lab Invest 7:134-137, 1958
    • (1958) Lab Invest , vol.7 , pp. 134-137
    • Bornstein, M.B.1
  • 5
    • 0023139866 scopus 로고
    • Identification of a substrate site for liver transglutaminase on the aminopropeptide of type III collagen
    • Bowness JM, Folk JE, Timpl R: Identification of a substrate site for liver transglutaminase on the aminopropeptide of type III collagen. J Biol Chem 262:1022-1024, 1987a
    • (1987) J Biol Chem , vol.262 , pp. 1022-1024
    • Bowness, J.M.1    Folk, J.E.2    Timpl, R.3
  • 6
    • 0023082528 scopus 로고
    • Components of increased labelling with putrescine and fucose during healing of skin wounds
    • Bowness JM, Henteleff H, Dolynchuk KN: Components of increased labelling with putrescine and fucose during healing of skin wounds. Connect Tissue Res 16:57-70, 1987b
    • (1987) Connect Tissue Res , vol.16 , pp. 57-70
    • Bowness, J.M.1    Henteleff, H.2    Dolynchuk, K.N.3
  • 7
    • 0023743868 scopus 로고
    • Increased transglutaminase activity during skin wound healing in rats
    • Bowness JM, Tarr AH, Wong T: Increased transglutaminase activity during skin wound healing in rats. Biochim Biophys Acta 967:234-240, 1988
    • (1988) Biochim Biophys Acta , vol.967 , pp. 234-240
    • Bowness, J.M.1    Tarr, A.H.2    Wong, T.3
  • 9
    • 0033545294 scopus 로고    scopus 로고
    • RGD peptides induce apoptosis by direct caspase-3 activation
    • Buckley CD, Pilling D, Henriquez NV: RGD peptides induce apoptosis by direct caspase-3 activation [see comments]. Nature 397:534-539, 1999
    • (1999) Nature , vol.397 , pp. 534-539
    • Buckley, C.D.1    Pilling, D.2    Henriquez, N.V.3
  • 10
    • 0033678547 scopus 로고    scopus 로고
    • Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance
    • Chodon T, Sugihara T, Igawa HH, Funayama E, Furukawa H: Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance. Am J Pathol 157:1661-1669, 2000
    • (2000) Am J Pathol , vol.157 , pp. 1661-1669
    • Chodon, T.1    Sugihara, T.2    Igawa, H.H.3    Funayama, E.4    Furukawa, H.5
  • 11
    • 0033926275 scopus 로고    scopus 로고
    • Delayed wound healing in immunodeficient TGF-beta 1 knockout mice
    • Crowe MJ, Doetschman T, Greenhalgh DG: Delayed wound healing in immunodeficient TGF-beta 1 knockout mice. J Invest Dermatol 115:3-11, 2000
    • (2000) J Invest Dermatol , vol.115 , pp. 3-11
    • Crowe, M.J.1    Doetschman, T.2    Greenhalgh, D.G.3
  • 12
    • 0028851160 scopus 로고
    • Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
    • Desmouliere A, Redard M, Darby I, Gabbiani G: Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56-66, 1995
    • (1995) Am J Pathol , vol.146 , pp. 56-66
    • Desmouliere, A.1    Redard, M.2    Darby, I.3    Gabbiani, G.4
  • 13
    • 0008701065 scopus 로고    scopus 로고
    • Inhibition of tissue transglutaminase and epsilon (gamma-glutamyl) lysine cross-linking in human hypertrophic scar
    • Dolynchuk KN: Inhibition of tissue transglutaminase and epsilon (gamma-glutamyl) lysine cross-linking in human hypertrophic scar. Wound Repair Regen 4:16-20, 1996
    • (1996) Wound Repair Regen , vol.4 , pp. 16-20
    • Dolynchuk, K.N.1
  • 14
    • 0028256523 scopus 로고
    • Effect of putrescine on tissue transglutaminase activity in wounds: Decreased breaking strength and increased matrix fucoprotein solubility
    • Dolynchuk KN, Bendor-Samuel R, Bowness JM: Effect of putrescine on tissue transglutaminase activity in wounds: Decreased breaking strength and increased matrix fucoprotein solubility. Plast Reconstr Surg 93:567-573, 1994
    • (1994) Plast Reconstr Surg , vol.93 , pp. 567-573
    • Dolynchuk, K.N.1    Bendor-Samuel, R.2    Bowness, J.M.3
  • 15
    • 0026407977 scopus 로고
    • Transglutaminase levels in Dupuytren's disease
    • Dolynchuk KN, Pettigrew NM: Transglutaminase levels in Dupuytren's disease. J Hand Surg [Am] 16:787-790, 1991
    • (1991) J Hand Surg [Am] , vol.16 , pp. 787-790
    • Dolynchuk, K.N.1    Pettigrew, N.M.2
  • 16
    • 0030060205 scopus 로고    scopus 로고
    • Topical putrescine (Fibrostat) in treatment of hypertrophic scars: Phase II study
    • discussion 124-115
    • Dolynchuk KN, Ziesmann M, Serletti JM: Topical putrescine (Fibrostat) in treatment of hypertrophic scars: Phase II study. Plast Reconstr Surg 97: 117-123, 1996 (discussion 124-115)
    • (1996) Plast Reconstr Surg , vol.97 , pp. 117-123
    • Dolynchuk, K.N.1    Ziesmann, M.2    Serletti, J.M.3
  • 17
    • 0031881747 scopus 로고    scopus 로고
    • Normal human primary fibroblasts undergo apoptosis in three-dimensional contractile collagen gels
    • Fluck J, Querfeld C, Cremer A, Niland S, Krieg T, Sollberg S: Normal human primary fibroblasts undergo apoptosis in three-dimensional contractile collagen gels. J Invest Dermatol 110:153-157, 1998
    • (1998) J Invest Dermatol , vol.110 , pp. 153-157
    • Fluck, J.1    Querfeld, C.2    Cremer, A.3    Niland, S.4    Krieg, T.5    Sollberg, S.6
  • 19
    • 0025129750 scopus 로고
    • Spatial organization of extracellular matrix and fibroblast activity: Effects of serum, transforming growth factor beta, and fibronectin
    • Fukamizu H, Grinnell F: Spatial organization of extracellular matrix and fibroblast activity: Effects of serum, transforming growth factor beta, and fibronectin. Exp Cell Res 190:276-282, 1990
    • (1990) Exp Cell Res , vol.190 , pp. 276-282
    • Fukamizu, H.1    Grinnell, F.2
  • 20
    • 0033544020 scopus 로고    scopus 로고
    • Tissue transglutaminase is an important player at the surface of human endothelial cells: Evidence for its externalization and its colocalization with the beta(1) integrin
    • Gaudry CA, Verderio E, Jones RA, Smith C, Griffin M: Tissue transglutaminase is an important player at the surface of human endothelial cells: Evidence for its externalization and its colocalization with the beta(1) integrin. Exp Cell Res 252:104-113, 1999
    • (1999) Exp Cell Res , vol.252 , pp. 104-113
    • Gaudry, C.A.1    Verderio, E.2    Jones, R.A.3    Smith, C.4    Griffin, M.5
  • 21
    • 0034855522 scopus 로고    scopus 로고
    • Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis
    • Grenard P, Bresson-Hadni S, El Alaoui S, Chevallier M, Vuitton DA, Ricard-Blum S: Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis. J Hepatol 35: 367-375, 2001
    • (2001) J Hepatol , vol.35 , pp. 367-375
    • Grenard, P.1    Bresson-Hadni, S.2    El Alaoui, S.3    Chevallier, M.4    Vuitton, D.A.5    Ricard-Blum, S.6
  • 22
    • 0036901574 scopus 로고    scopus 로고
    • Transglutaminases: Nature's biological glues
    • Griffin M, Casadio R, Bergamini CM: Transglutaminases: Nature's biological glues. Biochem J 368:377-396, 2002
    • (2002) Biochem J , vol.368 , pp. 377-396
    • Griffin, M.1    Casadio, R.2    Bergamini, C.M.3
  • 23
    • 0033134111 scopus 로고    scopus 로고
    • Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue
    • Grinnell F, Zhu M, Carlson MA, Abrams JM: Release of mechanical tension triggers apoptosis of human fibroblasts in a model of regressing granulation tissue. Exp Cell Res 248:608-619, 1999
    • (1999) Exp Cell Res , vol.248 , pp. 608-619
    • Grinnell, F.1    Zhu, M.2    Carlson, M.A.3    Abrams, J.M.4
  • 24
    • 0032824155 scopus 로고    scopus 로고
    • Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis
    • Haroon ZA, Hettasch JM, Lai TS, Dewhirst MW, Greenberg CS: Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. Faseb J 13:1787-1795, 1999
    • (1999) Faseb J , vol.13 , pp. 1787-1795
    • Haroon, Z.A.1    Hettasch, J.M.2    Lai, T.S.3    Dewhirst, M.W.4    Greenberg, C.S.5
  • 25
    • 10744227615 scopus 로고    scopus 로고
    • Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrading enzymes by endothelial cells and fibroblasts
    • Hirota A, Ebihara T, Kusubata M, et al: Collagen of chronically inflamed skin is over-modified and upregulates secretion of matrix metalloproteinase 2 and matrix-degrading enzymes by endothelial cells and fibroblasts. J Invest Dermatol 121:1317-1325, 2003
    • (2003) J Invest Dermatol , vol.121 , pp. 1317-1325
    • Hirota, A.1    Ebihara, T.2    Kusubata, M.3
  • 26
    • 0025360272 scopus 로고
    • Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type I collagen lattices
    • Kono T, Tanii T, Furukawa M, et al: Cell cycle analysis of human dermal fibroblasts cultured on or in hydrated type I collagen lattices. Arch Dermatol Res 282:258-262, 1990
    • (1990) Arch Dermatol Res , vol.282 , pp. 258-262
    • Kono, T.1    Tanii, T.2    Furukawa, M.3
  • 27
    • 0029088221 scopus 로고
    • The importance of the GTP-binding protein tissue transglutaminase in the regulation of cell cycle progression
    • Mian S, el Alaoui S, Lawry J, Gentile V, Davies PJ, Griffin M: The importance of the GTP-binding protein tissue transglutaminase in the regulation of cell cycle progression. FEBS Lett 370:27-31, 1995
    • (1995) FEBS Lett , vol.370 , pp. 27-31
    • Mian, S.1    El Alaoui, S.2    Lawry, J.3    Gentile, V.4    Davies, P.J.5    Griffin, M.6
  • 28
    • 2642536093 scopus 로고    scopus 로고
    • Tissue transglutaminase has intrinsic kinase activity: Identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase
    • Mishra S, Murphy LJ: Tissue transglutaminase has intrinsic kinase activity: Identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase. J Biol Chem 279:23863-23868, 2004
    • (2004) J Biol Chem , vol.279 , pp. 23863-23868
    • Mishra, S.1    Murphy, L.J.2
  • 29
    • 1242294533 scopus 로고    scopus 로고
    • Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors
    • Moulin V, Larochelle S, Langlois C, Thibault I, Lopez-Valle CA, Roy M: Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors. J Cell Physiol 198:350-358, 2004
    • (2004) J Cell Physiol , vol.198 , pp. 350-358
    • Moulin, V.1    Larochelle, S.2    Langlois, C.3    Thibault, I.4    Lopez-Valle, C.A.5    Roy, M.6
  • 30
    • 0025840251 scopus 로고
    • Intramolecular crosslinking of monomeric fibrinogen by tissue transglutaminase
    • Murthy SN, Wilson J, Guy SL, Lorand L: Intramolecular crosslinking of monomeric fibrinogen by tissue transglutaminase. Proc Natl Acad Sci USA 88:10601-10604, 1991
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10601-10604
    • Murthy, S.N.1    Wilson, J.2    Guy, S.L.3    Lorand, L.4
  • 31
    • 0024309946 scopus 로고
    • Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness
    • Nakagawa S, Pawelek P, Grinnell F: Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness. Exp Cell Res 182: 572-582, 1989a.
    • (1989) Exp Cell Res , vol.182 , pp. 572-582
    • Nakagawa, S.1    Pawelek, P.2    Grinnell, F.3
  • 32
    • 0024436719 scopus 로고
    • Long-term culture of fibroblasts in contracted collagen gels: Effects on cell growth and biosynthetic activity
    • Nakagawa S, Pawelek P, Grinnell F: Long-term culture of fibroblasts in contracted collagen gels: Effects on cell growth and biosynthetic activity. J Invest Dermatol 93:792-798, 1989b
    • (1989) J Invest Dermatol , vol.93 , pp. 792-798
    • Nakagawa, S.1    Pawelek, P.2    Grinnell, F.3
  • 33
    • 0028176166 scopus 로고
    • Gh: A GTP-binding protein with transglutaminase activity and receptor signaling function
    • Nakaoka H, Perez DM, Baek KJ, et al: Gh: A GTP-binding protein with transglutaminase activity and receptor signaling function. Science 264: 1593-1596, 1994
    • (1994) Science , vol.264 , pp. 1593-1596
    • Nakaoka, H.1    Perez, D.M.2    Baek, K.J.3
  • 34
    • 0024410036 scopus 로고
    • Growth rate of human fibroblasts is repressed by the culture within reconstituted collagen matrix but not by the culture on the matrix
    • Nishiyama T, Tsunenaga M, Nakayama Y, Adachi E, Hayashi T: Growth rate of human fibroblasts is repressed by the culture within reconstituted collagen matrix but not by the culture on the matrix. Matrix 9:193-199, 1989
    • (1989) Matrix , vol.9 , pp. 193-199
    • Nishiyama, T.1    Tsunenaga, M.2    Nakayama, Y.3    Adachi, E.4    Hayashi, T.5
  • 35
    • 0030974902 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
    • Nunes I, Gleizes PE, Metz CN, Rifkin DB: Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol 136:1151-1163, 1997
    • (1997) J Cell Biol , vol.136 , pp. 1151-1163
    • Nunes, I.1    Gleizes, P.E.2    Metz, C.N.3    Rifkin, D.B.4
  • 36
    • 0021683115 scopus 로고
    • Collagen biosynthesis by cells in a tissue equivalent matrix in vitro
    • Nusgens B, Merrill C, Lapiere C, Bell E: Collagen biosynthesis by cells in a tissue equivalent matrix in vitro. Coll Relat Res 4:351-363, 1984
    • (1984) Coll Relat Res , vol.4 , pp. 351-363
    • Nusgens, B.1    Merrill, C.2    Lapiere, C.3    Bell, E.4
  • 37
    • 0023498519 scopus 로고
    • Modulation of cellular biosynthetic activity in the retracting collagen lattice
    • Paye M, Nusgens BV, Lapiere CM: Modulation of cellular biosynthetic activity in the retracting collagen lattice. Eur J Cell Biol 45:44-50, 1987
    • (1987) Eur J Cell Biol , vol.45 , pp. 44-50
    • Paye, M.1    Nusgens, B.V.2    Lapiere, C.M.3
  • 38
    • 0030006390 scopus 로고    scopus 로고
    • Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis
    • Ricard-Blum S, Bresson-Hadni S, Guerret S, et al: Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis. Gastroenterology 111:172-182, 1996
    • (1996) Gastroenterology , vol.111 , pp. 172-182
    • Ricard-Blum, S.1    Bresson-Hadni, S.2    Guerret, S.3
  • 39
    • 0027690945 scopus 로고
    • Collagen cross-linking by pyridinoline occurs in non-reversible skin fibrosis
    • Ricard-Blum S, Esterre P, Grimaud JA: Collagen cross-linking by pyridinoline occurs in non-reversible skin fibrosis. Cell Mol Biol (Noisy-le-grand) 39: 723-727, 1993
    • (1993) Cell Mol Biol (Noisy-le-grand) , vol.39 , pp. 723-727
    • Ricard-Blum, S.1    Esterre, P.2    Grimaud, J.A.3
  • 40
    • 0031693720 scopus 로고    scopus 로고
    • Monitoring of extracellular matrix metabolism and cross-linking in tissue, serum and urine of patients with chromoblastomycosis, a chronic skin fibrosis
    • Ricard-Blum S, Hartmann DJ, Esterre P: Monitoring of extracellular matrix metabolism and cross-linking in tissue, serum and urine of patients with chromoblastomycosis, a chronic skin fibrosis. Eur J Clin Invest 28:748-754, 1998
    • (1998) Eur J Clin Invest , vol.28 , pp. 748-754
    • Ricard-Blum, S.1    Hartmann, D.J.2    Esterre, P.3
  • 41
    • 0036136943 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta-mediated apoptosis
    • Schuster N, Krieglstein K: Mechanisms of TGF-beta-mediated apoptosis. Cell Tissue Res 307:1-14, 2002
    • (2002) Cell Tissue Res , vol.307 , pp. 1-14
    • Schuster, N.1    Krieglstein, K.2
  • 42
    • 4344612698 scopus 로고    scopus 로고
    • Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses
    • Stephens P, Grenard P, Aeschlimann P, et al: Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. J Cell Sci 117:3389-3403, 2004
    • (2004) J Cell Sci , vol.117 , pp. 3389-3403
    • Stephens, P.1    Grenard, P.2    Aeschlimann, P.3
  • 44
    • 0022977704 scopus 로고
    • Reorganization of polymerized actin: A possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels
    • Unemori EN, Werb Z: Reorganization of polymerized actin: A possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gels. J Cell Biol 103:1021-1031, 1986
    • (1986) J Cell Biol , vol.103 , pp. 1021-1031
    • Unemori, E.N.1    Werb, Z.2
  • 45
    • 0032728955 scopus 로고    scopus 로고
    • Regulation of cell surface tissue transglutaminase: Effects on matrix storage of latent transforming growth factor-beta binding protein-1
    • Verderio E, Gaudry C, Gross S, Smith C, Downes S, Griffin M: Regulation of cell surface tissue transglutaminase: Effects on matrix storage of latent transforming growth factor-beta binding protein-1. J Histochem Cytochem 47:1417-1432, 1999
    • (1999) J Histochem Cytochem , vol.47 , pp. 1417-1432
    • Verderio, E.1    Gaudry, C.2    Gross, S.3    Smith, C.4    Downes, S.5    Griffin, M.6
  • 46
    • 0142242157 scopus 로고    scopus 로고
    • A novel RGD-independent cel adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis
    • Verderio EA, Telci D, Okoye A, Melino G, Griffin M: A novel RGD-independent cel adhesion pathway mediated by fibronectin-bound tissue transglutaminase rescues cells from anoikis. J Biol Chem 278:42604-42614, 2003
    • (2003) J Biol Chem , vol.278 , pp. 42604-42614
    • Verderio, E.A.1    Telci, D.2    Okoye, A.3    Melino, G.4    Griffin, M.5
  • 47
    • 0032519372 scopus 로고    scopus 로고
    • Differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar
    • Wassermann RJ, Polo M, Smith P, Wang X, Ko F, Robson MC: Differential production of apoptosis-modulating proteins in patients with hypertrophic burn scar. J Surg Res 75:74-80, 1998
    • (1998) J Surg Res , vol.75 , pp. 74-80
    • Wassermann, R.J.1    Polo, M.2    Smith, P.3    Wang, X.4    Ko, F.5    Robson, M.C.6
  • 48
    • 0017836095 scopus 로고
    • Collagen polymorphism in pathologic human scars
    • Weber L, Meigel WN, Spier W: Collagen polymorphism in pathologic human scars. Arch Dermatol Res 261:63-71, 1978
    • (1978) Arch Dermatol Res , vol.261 , pp. 63-71
    • Weber, L.1    Meigel, W.N.2    Spier, W.3


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