Expression of Bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars

Journal of Dermatological Science

Volumn 22, Issue 1, 1999, Pages 31-37

  Teofoli, P ^a   Barduagni, S ^a   Ribuffo, M ^b   Campanella, A ^a   De Pita', O ^a   Puddu, P ^a  

^a Ist Dermopat dell'Immacolata I ^*  (Italy)

^b VI Department of Dermatology   (Italy)

Author keywords

Bcl 2; c fos; C jun; Hypertrophic scars; Keloids; p53

Indexed keywords

KI 67 ANTIGEN; MESSENGER RNA; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN P53;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERTROPHIC SCAR; IMMUNOHISTOCHEMISTRY; KELOID; MITOSIS RATE; MORPHEA; ONCOGENE C FOS; PRIORITY JOURNAL; PROTO ONCOGENE; REGULATOR GENE; SKIN BIOPSY; SKIN FIBROBLAST; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CICATRIX, HYPERTROPHIC; GENE EXPRESSION; GENES, BCL-2; GENES, FOS; GENES, JUN; GENES, P53; HUMANS; KELOID; WOUND HEALING;

EID: 0032715511     PISSN: 09231811     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-1811(99)00040-7     Document Type: Article

References (14)

1. Friedman D.W., Boyd C.D., Mackienzie J.W. et al. Regulation of collagen expression in keloids and hypertrophic scars. J Surg Res. 55(2):1993;214-222.
2. Weedon D. Apoptosis. Adv Dermatol. 5:1990;243.
3. Paus R., Menrad A., Czarnetzki B.M. Necrobiology of the skin: apoptosis. Hautarzt. 46:1995;285-303.
4. Desmouliere A., Redard M., Darby I., Gabbiani G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol. 146(1):1995;56-66.
5. Angel P., Karin M. The role of jun, fos and the AP-1 complex in cell proliferation and transformation. Biochem Biophys Acta. 1072:1991;129-157.
6. Abergel R.P., Uitto J. Dermal fibrosis in cutaneous diseases: keloids as a model to study the mechanism of collagen deposition in tissues. Uitto J., Perejda A.J. Diseases of connective tissue: the molecular pathology of the extracellular matrix. 1989;345-366 Marcel Dekker, New York.
7. Cohen I.K., Keiser H.R., Sjoerdsma A. Collagen synthesis in human keloid and hypertrophic scar. Surg Forum. 22:1971;488-489.
8. Sinicrope F.A., Bao R.S., Clearly K.R., Sthepens L.C., Lee N., Levin B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res. 55:1995;237-241.
9. Paus R., Rosenbach T., Haas N., Czarnetzki B.M. Patterns of cell death: the significance of apoptosis for dermatology. Exp Dermatol. 2:1993;3-11.
10. Sollberg S., Peltonen J., Uitto J. Combined use of in situ hybridization and peroxidase-antiperoxidase and unlabeled antibody antiperoxidase methods: simultaneous detection of type I procollagen mRNAs and Factor VIII-related antigen epitopes in keloid tissue. Lab Invest. 64:1991;125-129.
11. Appleton I., Brown J.B., Willoughby D.A. Apoptosis, necrosis, and proliferation. Possible implications in the etiology of keloids. Am J Pathol. 149:1996;1441-1447.
12. Roberts A.B., Heine U.I., Flanders K.C., Sporn M.B. Transforming growth factor-β Fleischmajer R., Olsen B.R., Kuhn K. Structure, molecular biology, and pathology of collagen. Ann NY Acad Sci. 580:1990;225-232.
13. Ladin D.A., Hou Z., Patel D., McPhail M., Olson J.C., Saed G.M. et al. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen. 6(1):1998;28-37.
14. Wilkinson D.G., Bhatt S., Ryseck R.P., Bravo R. Tissue-specific expression of c-jun and junB during organogenesis in the mouse. Development. 106:1989;465-471.