A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcγRIIA transgenic mice

British Journal of Haematology

Volumn 130, Issue 1, 2005, Pages 130-137

  Van Royen Kerkhof, Annet ^a   Sanders, Elisabeth A M ^a   Walraven, Vanessa ^a   Voorhorst Ogink, Marleen ^b   Saeland, Eirikur ^a   Teeling, Jessica L ^b   Gerritsen, Arnout ^b   Van Dijk, Marc A ^b   Kuis, Wietse ^a   Rijkers, Ger T ^a   Vitale, Laura ^c   Keler, Tibor ^c   McKenzie, Steven E ^d   Leusen, Jeanette H W ^a,e   Van De Winkel, Jan G J ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b GENMAB   (Netherlands)

^c MEDAREX INC   (United States)

^d THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^e Department of Immunology   (Netherlands)

Author keywords

Antibodies; Autoimmunity; Fc receptors; Transgenic mice

Indexed keywords

CD32 ANTIGEN; CD64 ANTIGEN; HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY CD32; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G1 KAPPA CHAIN ANTIBODY; IMMUNOGLOBULIN KAPPA CHAIN; MDE 8; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; CELL STRAIN; CELL STRAIN THP 1; EXPERIMENTAL AUTOIMMUNE HEMOLYTIC ANEMIA; EXPERIMENTAL MEDICINE; FEMALE; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; RECEPTOR DENSITY; THROMBOCYTE; TRANSGENIC MOUSE;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CELLS, CULTURED; GRANULOCYTES; HUMANS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; PHAGOCYTOSIS; PLATELET ACTIVATION; RECEPTORS, IGG;

EID: 22144469485     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05571.x     Document Type: Article

References (41)

1. Berney, T., Shibata, T., Merino, R., Chicheportiche, Y., Kindler, V., Vassalli, P. & Izui, S. (1992) Murine autoimmune hemolytic anemia resulting from Fcγ receptor-mediated erythrophagocytosis: protection by erythropoietin but not by interleukin-3, and aggravation by granulocyte- macrophage colony-stimulating factor. Blood, 79, 2960-2964.
2. Braakman, E., van de Winkel, J.G.J., van Krimpen, B.A., Jansze, M. & Bolhuis, R.L. (1992) CD16 on human γδ lymphocytes: expression, function, and specificity for mouse IgG isotypes. Cellular Immunology, 143, 97-107.
3. Carlsson, L.E., Santoso, S., Baurichter, G., Kroll, H., Papenberg, S., Eichler, P., Westerdaal, N.A., Kiefel, V., van de Winkel, J.G.J. & Greinacher, A. (1998) Heparin-induced thrombocytopenia: new insights into the impact of the FcγRIIa-R-H131 polymorphism. Blood, 92, 1526-1531.
4. Clynes, R. & Ravetch, J.V. (1995) Cytotoxic antibodies trigger inflammation through Fc receptors. Immunity, 3, 21-26.
5. Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M. & Strober, W. (2002) Current Protocols in Immunology. Wiley & Sons, New York, NY.
6. Daeron, M. (1997) Fc receptor biology. Annual Review of Immunolgy, 15, 203-234.
7. Deo, Y.M., Graziano, R.F., Repp, R. & van de Winkel, J.G.J. (1997) Clinical significance of IgG Fc receptors and Fey R-directed immunotherapies. Immunology Today, 18, 127-135.
8. Dijstelbloem, H.M., Bijl, M., Fijnheer, R., Scheepers, R.H., Oost, W.W., Jansen, M.D., Sluiter, W.J., Limburg, P.C., Derksen, R.H., van de Winkel, J.G.J. & Kallenberg, G.G. (2000) Fey receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes. Arthritis and Rheumatism, 43, 2793-2800.
9. Drobyski, W.R., Potluri, J., Sauer, D. & Gottschall, J.L. (1996) Autoimmune hemolytic anemia following T cell-depleted allogeneic bone marrow transplantation. Bone Marrow Transplantation, 17, 1093-1099.
10. Fishwild, D.M., O'Donnell, S.L., Bengoechea, T., Hudson, D.V., Harding, F., Bernhard, S.L., Jones, D., Kay, R.M., Higgins, K.M., Schramm, S.R. & Lonberg, N. (1996) High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice. Nature Biotechnology, 14, 845-851.
11. Fleit, H.B. & Kobasiuk, C.D. (1991) The human monocyte-like cell line THP-I expresses FcγRI and FcγRII. Journal of Leukocyte Biology, 49, 556-565.
12. Fossati-Jimack, L., loan-Facsinay, A., Reininger, L., Chicheportiche, Y., Watanabe, N., Saito, T., Hofhuis, P.M., Gessner, J.E., Schiller, C., Schmidt, R.E., Honjo, T., Verbeek, J.S. & Izui, S. (2000) Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an anti-erythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcγ receptor III. Journal of Experimental Medicine, 191, 1293-1302.
13. Gehrs, B.C. & Friedberg, R.C. (2002) Autoimmune hemolytic anemia. American Journal of Hematology, 69, 258-271.
14. Guyre, P.M., Morganelli, P.M. & Miller, R. (1983) Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes. Journal of Clinical Investigations, 72, 393-397.
15. Hashimoto, C. (1998) Autoimmune hemolytic anemia. Clinical Reviews in Allergy and Immunology, 16, 285-295.
16. Hazenbos, W.L., Heijnen, I.A., Meyer, D., Hofhuis, P.M., Renardel de Lavalette, C.R., Schmidt, R.E., Capel, P.J., van de Winkel, J.G.J., Gessner, J.E., van den Berg, T.K. & Verbeek, J.S. (1998) Murine IgG1 complexes trigger immune effector functions predominantly via FcγRIII (CD16). Journal of Immunology, 161, 3026-3032.
17. van den Herik-Oudijk, I.E., Westerdaal, N.A., Henriquez, N.V., Capel, P.J. & van de Winkel, J.G.J. (1994) Functional analysis of human FcγRII (CD32) isoforms expressed in B lymphocytes. Journal of Immunology, 152, 574-585.
18. Ierino, F.L., Hulett, M.D., McKenzie, I.F. & Hogarth, P.M. (1993) Mapping epitopes of human FcγRII (CDw32) with monoclonal antibodies and recombinant receptors. Journal of Immunology, 150, 1794-1803.
19. Joutsi-Korhonen, L., Smethurst, P.A., Rankin, A., Gray, E., IJsseldijk, M., Onley, C.M., Watkins, N.A., Williamson, L.M., Goodall, A.H., de Groot, P.G., Farndale, R.W. & Ouwehand, W.H. (2003) The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression. Blood, 101, 4372-4379.
20. King, M., McDermott, P. & Schreiber, A.D. (1990) Characterization of the Fcγ receptor on human platelets. Cellular Immunology, 128, 462-479.
21. Kumpel, B.M. & Hadley, A.G. (1990) Functional interactions of red cells sensitized by IgG1 and IgG3 human monoclonal anti-D with enzyme-modified human monocytes and FcR-bearing cell lines. Molecular Immunology, 27, 247-256.
22. McKenzie, S.E., Taylor, S.M., Malladi, P., Yuhan, H., Cassel, D.L., Chien, P., Schwartz, E., Schreiber, A.D., Surrey, S. & Reilly, M.P. (1999) The role of the human Fc receptor FcγRIIA in the immune clearance of platelets: a transgenic mouse model. Journal of Immunology, 162, 4311-4318.
23. Meyer, D., Schiller, C., Westermann, J., Izui, S., Hazenbos, W.L., Verbeek, J.S., Schmidt, R.E. & Gessner, J.E. (1998) FcγRIII (CD16)-deficient mice show IgG isotype-dependent protection to experimental autoimmune hemolytic anemia. Blood, 92, 3997-4002.
24. Miescher, S., Spycher, M.O., Amstutz, H., De, H.M., Kleijer, M., Kalus, U.J., Radtke, H., Hubsch, A., Andresen, I., Martin, R.M. & Bidder, J. (2004) A single recombinant anti-RhD IgG prevents rhesus D immunization: association of RhD positive red blood cell clearance rate with polymorphisms in the FcγRIIA and IIIA genes. Blood, 103, 4028-4035.
25. Morton, H.C., van den Herik-Oudijk, I.E., Vossebeld, P., Snijders, A., Verhoeven, A.J., Capel, P.J., Sevan de Winkel, J.G.J. (1995) Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR γ-chain. Molecular basis for CD89/FcR γ-chain association. Journal of Biological Chemistry, 270, 29781-29787.
26. O'Brien, T.A., Eastlund, T., Peters, C., Neglia, J.P., Defer, T., Ramsay, N.K. & Scott Baker, K. (2004) Autoimmune haemolytic anaemia complicating haematopoietic cell transplantation in paediatric patients: high incidence and significant mortality in unrelated donor transplants for non-malignant diseases. British Journal of Haematology, 127, 67-75.
27. Park, S.Y., Ueda, S., Ohno, H., Hamano, Y., Tanaka, M., Shiratori, T., Yamazaki, T., Arase, H., Arase, N., Karasawa, A., Sato, S., Ledermann, B., Kondo, Y., Okumura, K., Ra, C. & Saito, T. (1998) Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. Journal of Clinical Investigations, 102, 1229-1238.
28. Pfefferkorn, L.C. & Fanger, M.W. (1989) Cross-linking of the high affinity Fc receptor for human immunoglobulin G1 triggers transient activation of NADPH oxidase activity. Continuous oxidase activation requires continuous de novo receptor cross-linking. Journal of Biological Chemistry, 264, 14112-14120.
29. van Royen-Kerkhof, A., Sanders, E.A., Wijngaarden, S., van Roon, J.A., Voorhorst-Ogink, M., Walraven, V., Gerritsen, A., van Dijk, M.A., Kuis, W., Rijkers, G.T., Keler, T., Leusen, J.H.W. & van de Winkel, J.G.J. (2004) Flow cytometric determination of FcγRIIa (CD32) polymorphism. Journal of Immunological Methods, 294, 135-144.
30. Rubinstein, E., Kouns, W.C., Jennings, L.K., Boucheix, C. & Carroll, R.C. (1991) Interaction of two GPIIb/IIIa monoclonal antibodies with platelet Fc receptor (FcγRII). British Journal of Haematology, 78, 80-86.
31. de Sa Oliveira, G.G., Izui, S., Ravirajan, C.T., Mageed, R.A., Lydyard, P.M., Elson, C.J. & Barker, R.N. (1996) Diverse antigen specificity of erythrocyte-reactive monoclonal autoantibodies from NZB mice. Clinical Experimental Immunology, 105, 313-320.
32. Shen, L., Guyre, P.M., Anderson, C.L. & Fanger, M.W. (1986) Heteroantibody-mediated cytotoxicity: antibody to the high affinity Fc receptor for IgG mediates cytotoxicity by human monocytes that is enhanced by interferon-γ and is not blocked by human IgG. Journal of Immunology, 137, 3378-3382.
33. Shibata, T., Berney, T., Reininger, L., Chicheportiche, Y., Ozaki, S., Shirai, T. & Izui, S. (1990) Monoclonal anti-erythrocyte autoantibodies derived from NZB mice cause autoimmune hemolytic anemia by two distinct pathogenic mechanisms. International Immunology, 2, 1133-1141.
34. van Spriel, A.B., Leusen, J.H.W., Vile, H. & van de Winkel, J.G.J. (2002) Mac-1 (CD11b/CD18) as accessory molecule for FcαR (CD89) binding of IgA. Journal of Immunology, 169, 3831-3836.
35. Sylvestre, D., Clynes, R., Ma, M., Warren, H., Carroll, M.C. & Ravetch, J.V. (1996) Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice. Journal of Experimental Medicine, 184, 2385-2392.
36. Takai, T., Li, M., Sylvestre, D., Clynes, R. & Ravetch, J.V. (1994) FcR γ-chain deletion results in pleiotrophic effector cell defects. Cell, 76, 519-529.
37. van Vugt, M.J., Heijnen, A.F., Capel, PJ., Park, S.Y., Ra, C., Saito, T., Verbeek, J.S. & van de Winkel, J.G.J. (1996) FcR γ-chain is essential for both surface expression and function of human FcγRI (CD64) in vivo. Blood, 87, 3593-3599.
38. Wallace, P.K., Keler, T., Coleman, K., Fisher, J., Vitale, L., Graziano, R.F., Guyre, P.M. & Fanger, M.W. (1997) Humanized mAb H22 binds the human high affinity Fc receptor for IgG (FcγRI), blocks phagocytosis, and modulates receptor expression. Journal of Leukocyte Biology, 62, 469-479.
39. van de Winkel, J.G.J. & Anderson, C.L. (1995) CD32 cluster workshop report V. In: Leucocyte Typing (ed. by S.F. Scholossman, L. Boumsell, W. Gilks, J.M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R. Silverstein, T.A. Springer, T.F. Tedder, R.F. Todd), pp. 823-826. Oxford University Press, Oxford.
40. van de Winkel, J.G.J., van Duijnhoven, H.L., van Ommen, R., Capel, P.J. & Tax, W.J. (1988) Selective modulation of two human monocyte Fc receptors for IgG by immobilized immune complexes. Journal of Immunology, 140, 3515-3521.
41. van de Winkel, J.G.J., Boonen, G.J., Janssen, P.L., Vlug, A., Hogg, N. & Tax, W.J. (1989) Activity of two types of Fc receptors, FcγRI and FcγRII, in human monocyte cytotoxicity to sensitized erythrocytes. Scandinavian Journal of Immunology, 29, 23-31.