Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor

International Journal of Cancer

Volumn 80, Issue 2, 1999, Pages 250-256

  Clement, Joachim H ^a   Sänger, Jörg ^b   Höffken, Klaus ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Institute of Pathology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; EPIDERMAL GROWTH FACTOR;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BONE MORPHOGENETIC PROTEINS; BREAST NEOPLASMS; CULTURE MEDIA, SERUM-FREE; EPIDERMAL GROWTH FACTOR; RECEPTOR, EPIDERMAL GROWTH FACTOR; REFERENCE VALUES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0033579799     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990118)80:2<250::AID-IJC14>3.0.CO;2-D     Document Type: Article

References (27)

1. BENTLEY, H., HAMDY, F.C., HART, K.A., SEID, J.M., WILLIAMS, J.L., JOHNSTONE, D. and RUSSELL, R.G.G., Expression of bone morphogenetic proteins in human prostatic adenocarcinoma and benign prostatic hyperplasia. Brit. J. Cancer. 66, 1159-1163 (1992).
2. BITGOOD, M.J. and MCMAHON, A.P., Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Develop. Biol., 172, 126-138 (1995).
3. BRADFORD, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
4. CELESTE, A.J., IANNAZZI, J.A., TAYLOR, R.C., HEWICK, R.M., ROSEN, V., WANG, E.A. and WOZNEY, J.M., Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone. Proc. nat. Acad. Sci. (Wash.), 87, 9843-9847 (1990).
5. COLEMAN, R.E. and RUBENS, R.D., The clinical course of bone metastases from breast cancer. Brit. J. Cancer, 55, 61-66 (1987).
6. DICKSON, R.B. and LIPPMAN, M.E., Growth factors in breast cancer. Endocr. Rev., 16, 559-589 (1995).
7. DROZDOFF, V., WALL, N.A. and PLEDGER, W.J., Expression and growth inhibitory effect of decapentaplegic Vg-related protein 6: evidence for a regulatory role in keratinocyte differentiation. Proc. nat. Acad. Sci. (Wash.), 91, 5528-5532 (1994).
8. FRY, D.W., KRAKER, A.J., MCMICHAEL, A., AMBROSO, L.A., NELSON, J.M., LEOPOLD, W.R., CONNORS, R.W. and BRIDGES, A.J., A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science, 265, 1093-1095 (1994).
9. GITELMAN, S.E., KOBRIN, M.S., YE, J.-Q., LOPEZ, A.R., LEE, A. and DERYNCK, R., Recombinant vgr-1/BMP-6 expressing tumors induce fibrosis and endochondral bone formation in vivo. J. Cell Biol., 126, 1595-1609 (1994).
10. HAMDY, F.C., AUTZEN, P., ROBINSON, M.C., HOdie;RNE, C.H.W., NEAL, D.E. and ROBSON, C.N., Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue. Cancer Res., 57, 4427-4431 (1997).
11. HARRIS, S.E., SABATINI, M., HARRIS, M.A., FENG, J.Q., WOZNEY, J. and MUNDY, G.R., Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells. J. Bone Miner. Res., 9, 389-394 (1994).
12. HELDIN, C.-H., Dimerization of cell surface receptors in signal transduction. Cell. 80, 213-223 (1995).
13. HELDIN, C.H., MIYAZOSO, K. and TEN DUKE, P., TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (Lond.), 390, 465-471 (1997).
14. HOGAN, B.L.M., Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Develop., 10, 1580-1594 (1996).
15. HSU, S.-M., RAINE., L. and FANGER, H., The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem., 29, 577-580 (1981).
16. JONES, C.M., LYONS, K.M. and HOGAN, B.L.M., Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development, 111, 531-542 (1991).
17. KING, C.R., KRAUS, M.H., WILLIAMS, L.T., MERLINO, G.T., PASTAN, I.H. and AARONSON, S.A., Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucl. Acids Res., 13, 8477-8486 (1985).
18. KLIJN, J.G., BERNS, P.M., SCHMITZ, P.I. and FOEKENS, J.A., The clinical significance of epidermal growth factor receptor (EGF-R) in human breast cancer: a review on 5232 patients. Endocr. Rev., 13, 3-17 (1992).
19. KNITTEL, T., FELLMER, P., MüLLER, L. and RAMADORI, G., Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-β1. Exp. Cell Res., 232, 263-269 (1997).
20. LYONS, K., GRAYCAR, J.L., LEE, A., HASHAMI, S., LINDQUIST, P.B., CHEN, E. Y., HOGAN, B.L.M. and DERYNCK, R., Vgr-1. a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor β superfamily. Proc. nat. Acad. Sci. (Wash.). 86, 4554-4558 (1989).
21. RICKARD, D.J., SPELSBERG, T.C. and RIGGS, B.L., Selective regulation by estrogen of gene expression for bone morphogenetic protein-6 in human osteoblastic cells. J. Bone Miner. Res., 11, S142 (1996).
22. RIESE, D.J., II, BERMINGHAM, Y., VAN RAAIJ, T.M., BUCKLEY, S., PLOWMAN, G.D. and STERN, D.F., Betacellulin activates the epidermal growth factor receptor and ERBB4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-β. Oncogene, 12, 345-353 (1996).
23. RIESE, D.J., II. KIM, E.D., ELENIUS, K., BUCKLEY, S., KLAGSBRUN, M., PLOWMAN, G.D. and STERN, D.F., The epidermal growth factor receptor couples transforming growth factor-α, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu. ERBB-3, and ERBB-4. J. biol. Chem., 271, 20047-20052 (1996).
24. SCHLUESENER, H.J. and MEYERMANN, R., Immunolocalization of BMP-6, a novel TGF-β-related cytokine, in normal and atherosclerotic smooth muscle cells. Atherosclerosis, 113, 153-156 (1995).
25. URIST, M.R., Bone: formation by autoinduction. Science, 150, 893-899 (1965).
26. WALL, N.A., BLESSING, M., WRIGHT, C.V.E. and HOGAN, B.L.M., Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). J. Cell Biol., 120, 493-502 (1993).
27. WOZNEY, J.M., ROSEN, V., CELESTE, A.J., MITSCOCK, L.M., WHITTERS, M.J., KRIZ, R.W., HEWICK, R.M. and WANG, E.A., Novel regulators of bone formation: molecular clones and activities. Science, 242, 1528-1534 (1988).