Partial resistance of ataxin-2-containing olivary and pontine neurons to axotomy-induced degeneration

Brain Research Bulletin

Volumn 66, Issue 3, 2005, Pages 212-221

  Viscomi, M T ^a   Florenzano, F ^a   Amadio, S ^a,b   Bernardi, G ^a,b   Molinari, M ^a,c  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Axotomy; Inferior olive; Poly Q diseases; Pontine nuclei; Purinergic receptors; Spinocerebellar ataxia type 2

Indexed keywords

ATAXIN 2; BRAIN PROTEIN; PURINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL POPULATION; CELL SURVIVAL; CEREBELLECTOMY; CONTROLLED STUDY; EXPERIMENTAL MODEL; IMMUNOFLUORESCENCE; MALE; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINOCEREBELLAR DEGENERATION; SPINOCEREBELLAR DEGENERATION TYPE 2;

ANIMALS; ANTIBODY SPECIFICITY; AXOTOMY; BLOTTING, WESTERN; CEREBELLAR NUCLEI; CEREBELLUM; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NEURONS; OLIVARY NUCLEUS; PONS; RATS; RATS, WISTAR;

EID: 22144451159     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2005.04.016     Document Type: Article

References (31)

1. C. Adams, S. Starkman, and S.M. Pulst Clinical and molecular analysis of a pedigree of southern Italian ancestry with spinocerebellar ataxia type 2 Neurology 49 1997 1163 1166
2. S.A. Azizi, and D.J. Woodward Inferior olivary nuclear complex of the rat: morphology and comments on the principles of organization within the olivocerebellar system J. Comp. Neurol. 263 1987 467 484
3. A. Buffo, M. Fronte, A.B. Oestreicher, and F. Rossi Degenerative phenomena and reactive modifications of the adult rat inferior olivary neurons following axotomy and disconnection from their targets Neuroscience 85 1998 587 604
4. D. Carulli, A. Buffo, and P. Strata Reparative mechanisms in the cerebellar cortex Prog. Neurobiol. 72 2004 373 398
5. A.J. Castro Projections of the superior cerebellar peduncle in rats and the development of new connections in response to neonatal hemicerebellectomy J. Comp. Neurol. 178 1978 611 627
6. E.S. Emamian, M.D. Kaytor, L.A. Duvick, T. Zu, S.K. Tousey, H.Y. Zoghbi, H.B. Clark, and H.T. Orr Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice Neuron 38 2003 375 387
7. F. Florenzano, M.T. Viscomi, F. Cavaliere, C. Volonté, and M. Molinari Cerebellar lesion up-regulates P2X1 and P2X2 purinergic receptors in precerebellar nuclei Neuroscience 115 2002 425 434
8. R.M. Friedlander Apoptosis and caspases in neurodegenerative diseases N. Engl. J. Med. 348 2003 1365 1375
9. F.R. Fusco, M.T. Viscomi, G. Bernardi, and M. Molinari Localization of ataxin-2 within the cerebellar cortex of the rat Brain Res. Bull. 56 2001 343 347
10. D.G. Gwyn, G.P. Nicholson, and B.A. Flumerfelt The inferior olivary nucleus of the rat: a light and electron microscopic study J. Comp. Neurol. 174 1977 489 520
11. D.P. Huynh, M.R. Del Bigio, D.H. Ho, and S.M. Pulst Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2 Anal. Neurol. 45 1999 232 241
12. A.H. Koeppen The hereditary ataxias J. Neuropathol. Exp. Neurol. 57 1998 531 543
13. S. Koyano, T. Uchihara, H. Fujigasaki, A. Nakamura, S. Yagishita, and K. Iwabuchi Neuronal intranuclear inclusions in spinocerebellar ataxia type 2: triple-labeling immunofluorescent study Neurosci. Lett. 273 1999 117 120
14. D. Kretzschmar, J. Tschape, D.C. Bettencourt, E. Asan, B. Poeck, R. Strauss, and G.O. Pflugfelder Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila Glia 49 2005 59 72
15. A.R. La Spada, and J.P. Taylor Polyglutamines placed into context Neuron 38 2003 681 684
16. M.M. Lipinski, and J. Yuan Mechanisms of cell death in polyglutamine expansion diseases Curr. Opin. Pharmacol. 4 2004 85 90
17. L.J. Martin, N.A. Al Abdulla, A.M. Brambrink, J.R. Kirsch, F.E. Sieber, and C. Portera-Cailliau Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis Brain Res. Bull. 46 1998 281 309
18. A. Michalik, and C. Van Broeckhoven Pathogenesis of polyglutamine disorders: aggregation revisited Hum. Mol. Genet. 12 2003 R173 R186 (Spec. No. 2)
19. M. Molinari, M. Bentivoglio, A. Granato, and D. Minciacchi Increased collateralization of the cerebellothalamic pathway following neonatal hemicerebellectomy Brain Res. 372 1986 1 10
20. T. Nechiporuk, D.P. Huynh, K. Figueroa, S. Sahba, A. Nechiporuk, and S.M. Pulst The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression Hum. Mol. Genet. 7 1998 1301 1309
21. C. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1986 Academic Press Sydney
22. C.A. Ross, and M.A. Poirier Protein aggregation and neurodegenerative disease Nat. Med. 10 2004 S10 S17
23. V. Tarlac, and E. Storey Role of proteolysis in polyglutamine disorders J. Neurosci. Res. 74 2003 406 416
24. P. Taylor, J. Hardy, and K.H. Fischbeck Toxic proteins in neurodegenerative disease Science 296 2002 1991 1995
25. J. Turnbull, E. Storey, V. Tarlac, R. Walsh, D. Stefani, R. Clark, and L. Kelly Different ataxin-2 antibodies display different immunoreactive profiles Brain Res. 1027 2004 103 116
26. M. Viau, and Y. Boulanger Characterization of ataxias with magnetic resonance imaging and spectroscopy Parkinsonism Relat. Disord. 10 2004 335 351
27. M.T. Viscomi, F. Florenzano, D. Conversi, G. Bernardi, and M. Molinari Axotomy dependent purinergic and nitrergic co-expression Neuroscience 123 2004 393 404
28. J.H. Weishaupt, and M. Bahr Degeneration of axotomized retinal ganglion cells as a model for neuronal apoptosis in the central nervous system - molecular death and survival pathways Restor. Neurol. Neurosci. 19 2001 19 27
29. R. Wiedemeyer, F. Westermann, I. Wittke, J. Nowock, and M. Schwab Ataxin-2 promotes apoptosis of human neuroblastoma cells Oncogene 22 2003 401 411
30. H.Y. Zoghbi The expanding world of ataxins Nat. Genet. 14 1996 237 238
31. H.Y. Zoghbi, and H.T. Orr Glutamine repeats and neurodegeneration Annu. Rev. Neurosci. 23 2000 217 247