Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Angewandte Chemie - International Edition

Volumn 44, Issue 27, 2005, Pages 4242-4244

  Lee, Seung Yub ^a   Liang, Fubo ^a   Guo, Xiao Ling ^a   Xie, Laiping ^a   Cahill, Sean M ^a   Blumenstein, Michael ^b   Yang, Heyi ^a   Lawrence, David S ^a   Zhang, Zhong Yin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Drug delivery; Inhibitors; Peptides; Prodrugs; Signal transduction

Indexed keywords

BIOCHEMISTRY; CELLS; MOLECULAR DYNAMICS;

CELL-PENETRATING PEPTIDE (CPP); CYTOTOXIC PROTEINS; DIPHTHERIA TOXINS; DISULFIDE BRIDGE;

PROTEINS;

ENZYME INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; HAMSTER; METABOLISM; SIGNAL TRANSDUCTION; SYNTHESIS;

ANIMALS; CHO CELLS; CRICETINAE; DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL TRANSDUCTION;

EID: 22144437028     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200462004     Document Type: Article

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