Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice

British Journal of Pharmacology

Volumn 145, Issue 4, 2005, Pages 424-431

  Shiota, Naotaka ^a   Kakizoe, Eiichi ^a   Shimoura, Keiko ^a   Tanaka, Tetsuya ^a   Okunishi, Hideki ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

Chymase inhibitor; Fibrosis; Mast cell; Scleroderma; Serine protease; TGF beta1

Indexed keywords

CHYMASE; CHYMASE 4; CHYMASE INHIBITOR; MESSENGER RNA; SUN C8257; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLERODERMA; SKIN FIBROSIS;

ANIMALS; CELL PROLIFERATION; CHYMASES; FIBROSIS; IMMUNOHISTOCHEMISTRY; MAST CELLS; MICE; MICE, INBRED C57BL; PROTEASE INHIBITORS; QUINAZOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SCLERODERMA, SYSTEMIC; SERINE ENDOPEPTIDASES; SKIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 22044451617     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706209     Document Type: Article

References (44)

1. BANOVAC, K. & DE FORTEZA, R. (1992). The effect of mast cell chymase on extracellular matrix: studies in autoimmune thyroiditis and in cultured thyroid cells. Int. Arch. Allergy Immunol., 99, 141-149.
2. CAUGHEY, G.H., LEIDIG, F., VIRO, N.F. & NADEL, J.A. (1988). Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J. Pharmacol. Exp. Ther., 244, 133-137.
3. CAUGHEY, G.H., RAYMOND, W.W. & WOLTERS, P.J. (2000). Angiotensin II generation by mast cell alpha- and beta-chymases. Biochim. Biophys. Acta, 1480, 245-257.
4. CLAMAN, H.N. (1989). Mast cell changes in a case of rapidly progressive scleroderma - ultrastructural analysis. J. Invest. Dermatol., 92, 290-295.
5. CLAMAN, H.N. (1993). Mast cells and fibrosis: hints from graft-versus-host disease and scleroderma. In: The Mast Cell in Health and Disease. Lung Biology in Health and Disease, eds. Kaliner, M.A. & Metcalfe, D.D. Vol. 62, pp. 653-667. New York: Marcel Dekker.
6. ENERBACK, L. & LOWHAGEN, G.B. (1979). Long term increase of mucosal mast cells in the rat induced by administration of compound 48/80. Cell Tissue Res., 198, 209-215.
7. EVERETT, E.T., PABLOS, J.L., HARLEY, R.A., LEROY, E.C. & NORRIS, J.S. (1995). The role of mast cells in the development of skin fibrosis in tight-skin mutant mice. Comp. Biochem. Physiol. A, 110, 159-165.
8. FANG, K.C., WOLTERS, P.J., STEINHOFF, M., BIDGOL, A., BLOUNT, J.L. & CAUGHEY, G.H. (1999). Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta. J. Immunol., 162, 5528-5535.
9. FUKAMI, H., IMAJO, S., ITO, A., KAKUTANI, S., SHIBATA, H., SUMIDA, M., TANAKA, T., NIWATA, S., SAITOH, M., KISO, Y., MIYAZAKI, M., OKUNISHI, H., URATA, H. & ARAKAWA, K. (2000). Substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase. Drug Des. Discov., 17, 69-84.
10. GABRIELLI, A., DI LORETO, C., TABORRO, R., CANDELA, M., SAMBO, P., NITTI, C., DANIELI, M.G., DELUSTRO, F., DASCH, J.R. & DANIELI, G. (1993). Immunohistochemical localization of intracellular and extracellular associated TGF beta in the skin of patients with systemic sclerosis (scleroderma) and primary Raynaud's phenomenon. Clin. Immunol. Immunopathol., 68, 340-349.
11. GREEN, M.C., SWEET, H.O. & BUNKER, L.E. (1976). Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton. Am. J. Pathol., 82, 493-512.
12. GRUBER, B.L. & KAUFMAN, L.D. (1990). Ketotifen-induced remission in progressive early diffuse scleroderma: evidence for the role of mast cells in disease pathogenesis. Am. J. Med., 89, 392-395.
13. HAWKINS, R.A., CLAMAN, H.N., CLARK, R.A. & STEIGERWALD, J.C. (1985). Increased dermal mast cell populations in progressive systemic sclerosis: a link in chronic fibrosis? Ann. Intern. Med., 102, 182-186.
14. HE, S., GACA, M.D., MCEUEN, A.R. & WALLS, A.F. (1999). Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells. J. Pharmacol. Exp. Ther., 291, 517-523.
15. HUANG, R.Y., BLOM, T. & HELLMAN, L. (1991). Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases. Eur. J. Immunol., 21, 1611-1621.
16. JIMENEZ, S.A. & CHRISTNER, P. (1994). Animal models of systemic sclerosis. Clin. Dermatol., 12, 425-436.
17. KAKIZOE, E., SHIOTA, N., TANABE, Y., SHIMOURA, K., KOBAYASHI, Y. & OKUNISHI, H. (2001). Isoform-selective upregulation of mast cell chymase in the development of skin fibrosis in scleroderma model mice. J. Invest. Dermatol., 116, 118-123.
18. KAWAKAMI, T., IHN, H., XU, W., SMITH, E., LEROY, C. & TROJANOWSKA, M. (1998). Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J. Invest, Dermatol., 110, 47-51.
19. LEVI-SCHAFFER, F. (1995). Mast cell/fibroblast interactions in health and disease. In: Human Basophils and Mast Cells: Biological Aspects Chemical Immunology, ed. Marone, G. Vol. 61, pp. 165-185. Basel: Karger.
20. LINDSTEDT, K.A., WANG, Y., SHIOTA, N, SAARINEN, J., HYYTIAINEN, M., KOKKONEN, J.O., KESKI-OJA, J. & KOVANEN, P.T. (2001). Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. FASEB J., 15, 1377-1388.
21. LONGLEY, B.J., TYRRELL, L., MA, Y., WILLIAMS, D.A., HALABAN, R., LANGLEY, K., LU, H.S. & SCHECHTER, N.M. (1997). Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proc. Natl. Acad. Sci. U.S.A., 94, 9017-9021.
22. MATSUMOTO, T., WADA, A., TSUTAMOTO, T., OHNISHI, M., ISONO, T. & KINOSHITA, M. (2003). Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation, 107, 2555-2558.
23. MAYES, M.D., LACEY JR, J.V., BEEBE-DIMMER, J., GILLESPIE, B.W., COOPER, B., LAING, T.J. & SCHOTTENFELD, D. (2003). Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum., 48, 2246-2255.
24. MENTON, D.N., HESS, R.A., LICHTENSTEIN, J.R. & EISEN, A. (1978). The structure and tensile properties of the skin of tight-skin (Tsk) mutant mice. J. Invest. Dermatol., 70, 4-10.
25. MIZUTANI, H., SCHECHTER, N., LAZARUS, G., BLACK, R.A. & KUPPER, T.S. (1991). Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J. Exp. Med., 174, 821-825.
26. NISHIKORI, Y., KAKIZOE, E., KOBAYASHI, Y., SHIMOURA, K., OKUNISHI, H. & DEKIO, S. (1998). Skin mast cell promotion of matrix remodeling in burn wound healing in mice: relevance of chymase. Arch. Dermatol. Res., 290, 553-560.
27. NISHIOKA, K., KOBAYASHI, Y., KATAYAMA, I. & TAKIJIRI, C. (1987). Mast cell numbers in diffuse scleroderma. Arch. Dermatol., 123, 205-208.
28. PAANANEN, K. & KOVANEN, P.T. (1994). Proteolysis and fusion of low density lipoprotein particles independently strengthen their binding to exocytosed mast cell granules. J. Biol. Chem., 269, 2023-2031.
29. REILLY, C.F., TEWKSBURY, D.A., SCHECHTER, N.M. & TRAVIS, J. (1982). Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J. Biol. Chem., 257, 8619-8622.
30. SAARINEN, J., KALKKINEN, N., WELGUS, H.G. & KOVANEN, P.T. (1994). Activation of human interstitial procollagenase through direct cleavage of the Leu83-Thr84 bond by mast cell chymase. J. Biol. Chem., 269, 18134-18140.
31. SCHICK, B., AUSTEN, K.F. & SCHWARTZ, L.B. (1984). Activation of rat serosal mast cells by chymase, an endogenous secretory granule protease. J. Immunol, 132, 2571-2577.
32. SEIBOLD, J.R., GIORNO, R.C. & CLAMAN, H.N. (1990). Dermal mast cell degranulation in systemic sclerosis. Arthritis Rheum., 33, 1702-1709.
33. SHIOTA, N., FUKAMIZU, A., OKUNISHI, H., TAKAI, S., MURAKAMI, K. & MIYAZAKI, M. (1998). Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts. Biochem. J., 333, 417-424.
34. SHIOTA, N., FUKAMIZU, A., TAKAI, S., OKUNISHI, H., MURAKAMI, K. & MIYAZAKI, M. (1997). Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart. J. Hypertens., 15, 431-440.
35. SHIOTA, N., OKUNISHI, H., FUKAMIZU, A., SAKONJO, H., KIKUMORI, M., NISHIMURA, T., NAKAGAWA, T., MURAKAMI, K. & MIYAZAKI, M. (1993). Activation of two angiotensin-generating systems in the balloon-injured artery. FEBS Lett., 323, 239-242.
36. SHIOTA, N., OKUNISHI, H., TAKAI, S., MIKOSHIBA, I., SAKONJO, H., SHIBATA, N. & MIYAZAKI, M. (1999). Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery. Circulation, 99, 1084-1090.
37. SPRINGMAN, E.B. & SERAFIN, W.E. (1995). Secretory endo- and exopeptidases of mouse mast cells: structure, genetics, and regulation of expression. In: Mast Cell Proteases in Immunology and Biology. Clinical Allergy and Immunology, ed. Caughey, G.H. Vol. 6, pp. 169-201. New York: Marcel Dekker.
38. TAIPALE, J., LOHI, J., SAARINEN, J., KOVANEN, P.T. & KESKI-OJA, J. (1995). Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells. J. Biol. Chem., 270, 4689-4696.
39. TOMIMORI, Y., MUTO, T., FUKAMI, H., SAITO, K., HORIKAWA, C., TSURUOKA, N., YAMASHIRO, K., SAITO, M., SUGIURA, N., SUMIDA, M., KAKUTANI, S. & FUKUDA, Y. (2002). Mast cell chymase regulates dermal mast cell number in mice. Biochem. Biophys. Res. Commun., 290, 1478-1482.
40. VARTIO, T., SEPPA, H. & VAHERI, A. (1981). Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G. J. Biol. Chem., 256, 471-477.
41. WALKER, M., HARLEY, R., MAIZE, J., DELUSTRO, F. & LEROY, E.C. (1985). Mast cells and their degranulation in the Tsk mouse model of scleroderma. Proc. Soc. Exp. Biol. Med., 180, 323-328.
42. WALKER, M.A., HARLEY, R.A. & LEROY, B.C. (1987). Inhibition of fibrosis in TSK mice by blocking mast cell degranulation. J. Rheumatol., 14, 299-301.
43. WATANABE, N., TOMIMORI, Y., SAITO, K., MIURA, K., WADA, A., TSUDZUKI, M. & FUKUDA, Y. (2002). Chymase inhibitor improves dermatitis in NC/Nga mice. Int. Arch. Allergy Immunol., 128, 229-234.
44. WYPIJ, D.M., NICHOLS, J.S., NOVAK, P.J., STACY, D.L., HERMAN, J. & WISEMAN, J.S. (1992). Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung. Biochem. Pharmacol., 43, 845-853.