-
1
-
-
0034029777
-
A phase II study of gemcitabine and 5-fluorouracil in metastatic pancreatic cancer: An Eastern Cooperative Oncology Group Study (E3296)
-
Berlin JD, Adak S, Vaughn DJ, Flinker D, Blaszkowsky L, Harris JE, Benson I (2000) A phase II study of gemcitabine and 5-fluorouracil in metastatic pancreatic cancer: an Eastern Cooperative Oncology Group Study (E3296). Oncology 58: 215-218
-
(2000)
Oncology
, vol.58
, pp. 215-218
-
-
Berlin, J.D.1
Adak, S.2
Vaughn, D.J.3
Flinker, D.4
Blaszkowsky, L.5
Harris, J.E.6
Benson, I.7
-
2
-
-
0032458114
-
A phase I study of gemcitabine, 5-fluorouracil and leucovorin in patients with advanced, recurrent, and/or metastatic solid tumors
-
Berlin JD, Alberti DB, Arzoomanian RZ, Feierabend CA, Simon KJ, Binger KA, Marnocha RM, Wilding G (1998) A phase I study of gemcitabine, 5-fluorouracil and leucovorin in patients with advanced, recurrent, and/or metastatic solid tumors. Invest New Drugs 16: 325-330
-
(1998)
Invest New Drugs
, vol.16
, pp. 325-330
-
-
Berlin, J.D.1
Alberti, D.B.2
Arzoomanian, R.Z.3
Feierabend, C.A.4
Simon, K.J.5
Binger, K.A.6
Marnocha, R.M.7
Wilding, G.8
-
3
-
-
0036682041
-
Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
-
Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson III AB (2002) Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 20: 3270-3275
-
(2002)
J Clin Oncol
, vol.20
, pp. 3270-3275
-
-
Berlin, J.D.1
Catalano, P.2
Thomas, J.P.3
Kugler, J.W.4
Haller, D.G.5
Benson III, A.B.6
-
4
-
-
0001437359
-
Ex vivo ATP tumor testing of gemcitabine for combination chemotherapy and biochemical modulation
-
abstr 2116
-
Bruckner H, Zhou G, Haenel P (1998) Ex vivo ATP tumor testing of gemcitabine for combination chemotherapy and biochemical modulation. Proc Am Assoc Cancer Res 89: 310 (abstr 2116)
-
(1998)
Proc Am Assoc Cancer Res
, vol.89
, pp. 310
-
-
Bruckner, H.1
Zhou, G.2
Haenel, P.3
-
5
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris III HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P, Nelson R, Dorr FA, Stephens CD, Von Hoff DD (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15: 2403-2413
-
(1997)
J Clin Oncol
, vol.15
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
Green, M.R.4
Rothenberg, M.L.5
Modiano, M.R.6
Cripps, M.C.7
Portenoy, R.K.8
Storniolo, A.M.9
Tarassoff, P.10
Nelson, R.11
Dorr, F.A.12
Stephens, C.D.13
Von Hoff, D.D.14
-
6
-
-
0033029525
-
A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)
-
Cascinu S, Silva RR, Barni S, Labianca R, Frontini L, Piazza E, Pancera G, Giordani P, Giuliodori L, Pessi MA, Fusco V, Luporini G, Cellerino R, Catalano G (1999) A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). Br J Cancer 80: 1595-1598
-
(1999)
Br J Cancer
, vol.80
, pp. 1595-1598
-
-
Cascinu, S.1
Silva, R.R.2
Barni, S.3
Labianca, R.4
Frontini, L.5
Piazza, E.6
Pancera, G.7
Giordani, P.8
Giuliodori, L.9
Pessi, M.A.10
Fusco, V.11
Luporini, G.12
Cellerino, R.13
Catalano, G.14
-
7
-
-
0038579652
-
Phase II trial with S-1 in chemotherapy-naive patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG)
-
Chollet P, Schoffski P, Weigang-Kohler K, Schellens JH, Cure H, Pavlidis N, Grunwald V, De Boer R, Wanders J, Fumoleau P (2003) Phase II trial with S-1 in chemotherapy-naive patients with gastric cancer. A trial performed by the EORTC Early Clinical Studies Group (ECSG). Eur J Cancer 39: 1264-1270
-
(2003)
Eur J Cancer
, vol.39
, pp. 1264-1270
-
-
Chollet, P.1
Schoffski, P.2
Weigang-Kohler, K.3
Schellens, J.H.4
Cure, H.5
Pavlidis, N.6
Grunwald, V.7
De Boer, R.8
Wanders, J.9
Fumoleau, P.10
-
8
-
-
0001857276
-
Cancer of the pancreas
-
De Vita VJ, Hellman S, Rosenberg S (eds). Philadelphia: Lippincott
-
Evans D, Abbruzzese J, Rich T (1997) Cancer of the pancreas. In Cancer: Principles and Practice of Oncology De Vita VJ, Hellman S, Rosenberg S (eds) pp 1054-1077. Philadelphia: Lippincott
-
(1997)
Cancer: Principles and Practice of Oncology
, pp. 1054-1077
-
-
Evans, D.1
Abbruzzese, J.2
Rich, T.3
-
9
-
-
0029816590
-
Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer
-
Glimelius B, Hoffman K, Sjödén PO, Jacobsson G, Sellstrom H, Enander LK, Linne T, Svensson C (1996) Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7: 593-600
-
(1996)
Ann Oncol
, vol.7
, pp. 593-600
-
-
Glimelius, B.1
Hoffman, K.2
Sjödén, P.O.3
Jacobsson, G.4
Sellstrom, H.5
Enander, L.K.6
Linne, T.7
Svensson, C.8
-
10
-
-
0033012340
-
Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
-
Hidalgo M, Castellano D, Paz-Ares L, Gravalos C, Diaz-Puente M, Hitt R, Alonso S Cortes-Funes H (1999) Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer. J Clin Oncol 17: 585-592
-
(1999)
J Clin Oncol
, vol.17
, pp. 585-592
-
-
Hidalgo, M.1
Castellano, D.2
Paz-Ares, L.3
Gravalos, C.4
Diaz-Puente, M.5
Hitt, R.6
Alonso, S.7
Cortes-Funes, H.8
-
11
-
-
0037243332
-
Phase I study with pharmacokinetics of S-1 on an oral daily schedule for 28 days in patients with solid tumors
-
Hoff PM, Saad ED, Ajani JA, Lassere Y, Wenske C, Medgyesy D, Dwivedy S, Russo M, Pazdur R (2003) Phase I study with pharmacokinetics of S-1 on an oral daily schedule for 28 days in patients with solid tumors. Clin Cancer Res 9: 134-142
-
(2003)
Clin Cancer Res
, vol.9
, pp. 134-142
-
-
Hoff, P.M.1
Saad, E.D.2
Ajani, J.A.3
Lassere, Y.4
Wenske, C.5
Medgyesy, D.6
Dwivedy, S.7
Russo, M.8
Pazdur, R.9
-
12
-
-
0035489130
-
Late phase II study of S-1 in patients with advanced head and neck cancer
-
Inuyama Y, Kida A, Tsukuda M, Kohno N, Satake B (2001) Late phase II study of S-1 in patients with advanced head and neck cancer. Gan To Kagaku Ryoho 28: 1381-1390
-
(2001)
Gan to Kagaku Ryoho
, vol.28
, pp. 1381-1390
-
-
Inuyama, Y.1
Kida, A.2
Tsukuda, M.3
Kohno, N.4
Satake, B.5
-
13
-
-
0034029776
-
Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer
-
For the S-1 Cooperative Gastric Cancer Study Group
-
Koizumi W, Kurihara M, Nakano S, Hasegawa K (2000) Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group. Oncology 58: 191-197
-
(2000)
Oncology
, vol.58
, pp. 191-197
-
-
Koizumi, W.1
Kurihara, M.2
Nakano, S.3
Hasegawa, K.4
-
14
-
-
0034025452
-
Gemcitabine combined with continuous infusion 5-fluorouracil in advanced and symptomatic pancreatic cancer: A clinical benefit-oriented phase II study
-
Matano E, Tagliaferri P, Libroia A, Damiano V, Fabbrocini A, De Lorenzo S, Bianco AR (2000) Gemcitabine combined with continuous infusion 5-fluorouracil in advanced and symptomatic pancreatic cancer: a clinical benefit-oriented phase II study. Br J Cancer 82: 1772-1775
-
(2000)
Br J Cancer
, vol.82
, pp. 1772-1775
-
-
Matano, E.1
Tagliaferri, P.2
Libroia, A.3
Damiano, V.4
Fabbrocini, A.5
De Lorenzo, S.6
Bianco, A.R.7
-
15
-
-
12144288807
-
Pancreatic Cancer Registry in Japan: 20 Years of experience
-
Matsuno S, Egawa S, Fukuyama S, Motoi F, Sunamura M, Isaji S, Imaizumi T, Okada S, Kato H, Suda K, Nakao A, Hiraoka T, Hosotani R, Takeda K (2004) Pancreatic Cancer Registry in Japan: 20 years of experience. Pancreas 28: 219-230
-
(2004)
Pancreas
, vol.28
, pp. 219-230
-
-
Matsuno, S.1
Egawa, S.2
Fukuyama, S.3
Motoi, F.4
Sunamura, M.5
Isaji, S.6
Imaizumi, T.7
Okada, S.8
Kato, H.9
Suda, K.10
Nakao, A.11
Hiraoka, T.12
Hosotani, R.13
Takeda, K.14
-
16
-
-
0034089123
-
Phase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma
-
S-1 Cooperative Colorectal Carcinoma Study Group
-
Ohtsu A, Baba H, Sakata Y, Mitachi Y, Horikoshi N, Sugimachi K, Taguchi T (2000) Phase II study of S-1, a novel oral fluorophyrimidine derivative, in patients with metastatic colorectal carcinoma. S-1 Cooperative Colorectal Carcinoma Study Group. Br J Cancer 83: 141-145
-
(2000)
Br J Cancer
, vol.83
, pp. 141-145
-
-
Ohtsu, A.1
Baba, H.2
Sakata, Y.3
Mitachi, Y.4
Horikoshi, N.5
Sugimachi, K.6
Taguchi, T.7
-
17
-
-
0011777614
-
A phase II and pharmacokinetic trial of S-1 in patients with advanced pancreatic cancer
-
Okada S, Okusaka T, Ueno H (2002) A phase II and pharmacokinetic trial of S-1 in patients with advanced pancreatic cancer. Proc Am Soc Clin Oncol 21: 171a
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Okada, S.1
Okusaka, T.2
Ueno, H.3
-
18
-
-
0026045814
-
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa
-
Peters GJ, van Groeningen CJ, Laurensse EJ, Pinedo HM (1991) A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa. Cancer 68: 1903-1909
-
(1991)
Cancer
, vol.68
, pp. 1903-1909
-
-
Peters, G.J.1
Van Groeningen, C.J.2
Laurensse, E.J.3
Pinedo, H.M.4
-
19
-
-
0034327360
-
Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity
-
Rauchwerger DR, Firby PS, Hedley DW, Moore MJ (2000) Equilibrative- sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 60: 6075 - 6079
-
(2000)
Cancer Res
, vol.60
, pp. 6075-6079
-
-
Rauchwerger, D.R.1
Firby, P.S.2
Hedley, D.W.3
Moore, M.J.4
-
20
-
-
8944261362
-
A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
-
Rothenberg ML, Moore MJ, Cripps MC, Andersen JS, Portenoy RK, Burris III HA, Green MR, Tarassoff PG, Brown TD, Casper ES, Storniolo AM, Von Hoff DD (1996) A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer. Ann Oncol 7: 347-353
-
(1996)
Ann Oncol
, vol.7
, pp. 347-353
-
-
Rothenberg, M.L.1
Moore, M.J.2
Cripps, M.C.3
Andersen, J.S.4
Portenoy, R.K.5
Burris III, H.A.6
Green, M.R.7
Tarassoff, P.G.8
Brown, T.D.9
Casper, E.S.10
Storniolo, A.M.11
Von Hoff, D.D.12
-
21
-
-
16544365052
-
A phase II study of S-1 in patients with metastatic breast cancer - A Japanese trial by the S-1 cooperative study group, Breast Cancer Working Group
-
Saeki T, Takashima S, Sano M, Horikoshi N, Miura S, Shimizu S, Morimoto K, Kimura M, Aoyama H, Ota J, Noguchi S, Taguchi T (2004) A phase II study of S-1 in patients with metastatic breast cancer - A Japanese trial by the S-1 cooperative study group, Breast Cancer Working Group. Breast Cancer 11: 194-202
-
(2004)
Breast Cancer
, vol.11
, pp. 194-202
-
-
Saeki, T.1
Takashima, S.2
Sano, M.3
Horikoshi, N.4
Miura, S.5
Shimizu, S.6
Morimoto, K.7
Kimura, M.8
Aoyama, H.9
Ota, J.10
Noguchi, S.11
Taguchi, T.12
-
22
-
-
0032189218
-
Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 Mtegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients
-
Sakata Y, Ohtsu A, Horikoshi N, Sugimachi K, Mitachi Y, Taguchi T (1998) Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 Mtegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients. Eur J Cancer 34: 1715-1720
-
(1998)
Eur J Cancer
, vol.34
, pp. 1715-1720
-
-
Sakata, Y.1
Ohtsu, A.2
Horikoshi, N.3
Sugimachi, K.4
Mitachi, Y.5
Taguchi, T.6
-
23
-
-
9344248389
-
Antitumor activity of 1 Mtegafur-0.4 M 5-chloro-2,4-dihydroxy-pyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats
-
Shirasaka T, Nakano K, Takechi T, Satake H, Uchida J, Fujioka A, Saito H, Okabe H, Oyama K, Takeda S, Unemi N, Fukushima M (1996a) Antitumor activity of 1 Mtegafur-0.4 M 5-chloro-2,4-dihydroxy-pyridine-1 M potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats. Cancer Res 56: 2602-2606
-
(1996)
Cancer Res
, vol.56
, pp. 2602-2606
-
-
Shirasaka, T.1
Nakano, K.2
Takechi, T.3
Satake, H.4
Uchida, J.5
Fujioka, A.6
Saito, H.7
Okabe, H.8
Oyama, K.9
Takeda, S.10
Unemi, N.11
Fukushima, M.12
-
24
-
-
0029835349
-
Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators
-
Shirasaka T, Shimamoto Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K, Fukushima M (1996b) Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 7: 548-557
-
(1996)
Anticancer Drugs
, vol.7
, pp. 548-557
-
-
Shirasaka, T.1
Shimamoto, Y.2
Ohshimo, H.3
Yamaguchi, M.4
Kato, T.5
Yonekura, K.6
Fukushima, M.7
-
25
-
-
10744224587
-
Phase I study of S-1
-
S-1 Study Group
-
Taguchi T, Inuyama Y, Kanamaru R, Hasegawa K, Akazawa S, Niitani H, Furue H, Kurihara M, Ota K, Suga S, Ariyoshi Y, Takai S, Shimoyama T, Toge T, Takashima S, Sugimachi K, Hara Y, Fujita H, Kimura K, Saito T, Tsukagoshi S, Nakao I (1997) Phase I study of S-1. S-1 Study Group. Can To Kagaku Ryoho 24: 2253-2264
-
(1997)
Can to Kagaku Ryoho
, vol.24
, pp. 2253-2264
-
-
Taguchi, T.1
Inuyama, Y.2
Kanamaru, R.3
Hasegawa, K.4
Akazawa, S.5
Niitani, H.6
Furue, H.7
Kurihara, M.8
Ota, K.9
Suga, S.10
Ariyoshi, Y.11
Takai, S.12
Shimoyama, T.13
Toge, T.14
Takashima, S.15
Sugimachi, K.16
Hara, Y.17
Fujita, H.18
Kimura, K.19
Saito, T.20
Tsukagoshi, S.21
Nakao, I.22
more..
-
26
-
-
0036275282
-
Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells
-
Takechi T, Fujioka A, Matsushima E, Fukushima M (2002) Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer 38: 1271-1277
-
(2002)
Eur J Cancer
, vol.38
, pp. 1271-1277
-
-
Takechi, T.1
Fujioka, A.2
Matsushima, E.3
Fukushima, M.4
-
27
-
-
0031060433
-
Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats
-
Takechi T, Nakano K, Uchida J, Mita A, Toko K, Takeda S, Unemi N, Shirasaka T (1997) Antitumor activity and low intestinal toxicity of S-1, a new formulation of oral tegafur, in experimental tumor models in rats. Cancer Chemother Pharmacol 39: 205-211
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 205-211
-
-
Takechi, T.1
Nakano, K.2
Uchida, J.3
Mita, A.4
Toko, K.5
Takeda, S.6
Unemi, N.7
Shirasaka, T.8
-
28
-
-
0023250474
-
Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts
-
Tatsumi K, Fukushima M, Shirasaka T, Fujii S (1987) Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts. Jpn J Cancer Res 78: 748-755
-
(1987)
Jpn J Cancer Res
, vol.78
, pp. 748-755
-
-
Tatsumi, K.1
Fukushima, M.2
Shirasaka, T.3
Fujii, S.4
-
29
-
-
0037430037
-
EORTC early clinical studies group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer
-
Van den Brande J, Schoffski P, Schellens JH, Roth AD, Duffaud F, Weigang-Kohler K, Reinke F, Wanders J, de Boer RF, Vermerken JB, Fumoleau P (2003) EORTC early clinical studies group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer. Br J Cancer 88: 648-653
-
(2003)
Br J Cancer
, vol.88
, pp. 648-653
-
-
Van Den Brande, J.1
Schoffski, P.2
Schellens, J.H.3
Roth, A.D.4
Duffaud, F.5
Weigang-Kohler, K.6
Reinke, F.7
Wanders, J.8
De Boer, R.F.9
Vermerken, J.B.10
Fumoleau, P.11
-
30
-
-
18244414936
-
Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors
-
van Groeningen CJ, Peters GJ, Schornagel JH, Gall H, Noordhuis P, de Vries MJ, Turner SL, Swart MS, Pinedo HM, Hanauske AR, Giaccone G (2000) Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors. J Clin Oncol 18: 2772-2779
-
(2000)
J Clin Oncol
, vol.18
, pp. 2772-2779
-
-
Groeningen, C.J.1
Peters, G.J.2
Schornagel, J.H.3
Gall, H.4
Noordhuis, P.5
De Vries, M.J.6
Turner, S.L.7
Swart, M.S.8
Pinedo, H.M.9
Hanauske, A.R.10
Giaccone, G.11
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