Differences in the in vivo dynamics of neurotransmitter release and serotonin uptake after acute para-methoxyamphetamine and 3,4- methylenedioxymethamphetamine revealed by chronoamperometry

Neurochemistry International

Volumn 47, Issue 5, 2005, Pages 350-361

  Callaghan, Paul D ^a,b   Irvine, Rodney J ^b   Daws, Lynette C ^a,b  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

3,4 Methylenedioxymethamphetamine; Chronoamperometry; Dopamine transporter; Para methoxyamphetamine; Release; Serotonin transporter; Uptake

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 METHOXYAMPHETAMINE; AMPHETAMINE; NEUROTRANSMITTER; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

AMPEROMETRY; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DYNAMICS; ELECTROCHEMISTRY; HIPPOCAMPUS; MALE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN UPTAKE;

AMPHETAMINES; ANIMALS; CALIBRATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCHEMISTRY; ELECTRODES; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTRANSMITTER AGENTS; OXIDATION-REDUCTION; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS; SEROTONIN UPTAKE INHIBITORS; ZIMELDINE;

EID: 22044434012     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.04.026     Document Type: Article

References (77)

1. M.G. Bankson, and K.A. Cunningham Pharmacological studies of the acute effects of (+)-3,4- methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors Neuropsychopharmacology 26 2002 40 52
2. M.F. Beal, and J.B. Martin Topographical dopamine and serotonin distribution and turnover in rat striatum Brain. Res. 358 1985 10 15
3. S. Benmansour, S.M. Tejani-Butt, M. Hauptmann, and D.J. Brunswick Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography Psychopharmacology (Berl) 106 1992 459 462
4. S. Benmansour, M. Cecchi, D.A. Morilak, G.A. Gerhardt, M.A. Javors, G.G. Gould, and A. Frazer Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level J. Neurosci. 19 1999 10494 10501
5. S. Benmansour, W.A. Owens, M. Cecchi, D.A. Morilak, and A. Frazer Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter J. Neurosci. 22 2002 6766 6772
6. M.A. Bunin, and R.M. Wightman Quantitative evaluation of 5-hydroxytryptamine (serotonin) neuronal release and uptake: an investigation of extrasynaptic transmission J. Neurosci. 18 1998 4854 4860
7. C.W. Callaway, L.L. Wing, and M.A. Geyer Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats J. Pharmacol. Exp. Ther. 254 1990 456 464
8. W.A. Cass, N.R. Zahniser, K.A. Flach, and G.A. Gerhardt Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors J. Neurochem. 61 1993 2269 2278
9. Z. Chodorowski, M. Wiergowski, and J. Sein Anand Fatal intoxication with paramethoxyamphetamine Przegl Lek 59 2002 379 380
10. G. Cimbura PMA deaths in Ontario Can. Med. Assoc. J. 110 1974 1263 1267
11. S.J. Cragg, and M.E. Rice Dancing past the DAT at a dopamine synapse Trends Neurosci. 27 2004 270 277
12. D. Crespi, T. Mennini, and M. Gobbi Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine Br. J. Pharmacol. 121 1997 1735 1743
13. R.I. Dafters Hyperthermia following MDMA administration in rats: effects of ambient temperature, water consumption, and chronic dosing Physiol. Behav. 58 1995 877 882
14. R.I. Dafters, and E. Lynch Persistent loss of thermoregulation in the rat induced by 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") but not by fenfluramine Psychopharmacology (Berl) 138 1998 207 212
15. L.C. Daws, G.M. Toney, D.J. Davis, G.A. Gerhardt, and A. Frazer In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus J. Neurosci. Methods 78 1997 139 150
16. L.C. Daws, G.M. Toney, G.A. Gerhardt, and A. Frazer In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters J. Pharmacol. Exp. Ther. 286 1998 967 976
17. L.C. Daws, G.G. Gould, S.D. Teicher, G.A. Gerhardt, and A. Frazer 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo J. Neurochem. 75 2000 2113 2122
18. L.C. Daws, R.J. Irvine, P.D. Callaghan, N.P. Toop, J.M. White, and F. Bochner Differential behavioural and neurochemical effects of paramethoxyamphetamine and 3,4-methylenedioxymethamphetamine in the rat Prog. Neuropsychopharmacol. Biol. Psychiatry. 24 2000 955 977
19. L.C. Daws, S. Montañez, W.A. Owens, G.G. Gould, A. Frazer, G.M. Toney, and G.A. Gerhardt Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry J. Neurosci. Meth. 143 2005 49 62 (special edition)
20. B. Esteban, E. O'Shea, J. Camarero, V. Sanchez, A.R. Green, and M.I. Colado 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose Psychopharmacology (Berl) 154 2001 251 260
21. H.E. Felgate, P.D. Felgate, R.A. James, D.N. Sims, and D.C. Vozzo Recent paramethoxyamphetamine deaths J. Anal. Toxicol. 22 1998 169 172
22. P.A. Garris, E.L. Ciolkowski, and R.M. Wightman Heterogeneity of evoked dopamine overflow within the striatal and striatoamygdaloid regions Neuroscience 59 1994 417 427
23. G.A. Gerhardt, and J. Burmeister In vivo voltammetry for chemical analysis of the nervous system R.A. Meyers Encyclopedia of Analytical Chemistry: Instrumentation and Applications 2000 John Wiley & Sons Ltd. Chichester 710 731
24. G.A. Gerhardt, and A.F. Hoffman Effect of recording media composition on the responses of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry J. Neurosci. Meth. 109 2001 13 21
25. G.E. Glynn, and B.K. Yamamoto In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen Brain. Res. 481 1989 235 241
26. C.J. Gordon, W.P. Watkinson, J.P. O'Callaghan, and D.B. Miller Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat Pharmacol. Biochem. Behav. 38 1991 339 344
27. B. Gough, S.F. Ali, W. Slikker Jr., and R.R. Holson Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate Pharmacol. Biochem. Behav. 39 1991 619 623
28. B. Gough, S.Z. Imam, B. Blough, W. Slikker Jr., and S.F. Ali Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate: a microdialysis study Ann. N.Y. Acad. Sci. 965 2002 410 420
29. L.R. Gowing, S.M. Henry-Edwards, R.J. Irvine, and R.L. Ali The health effects of ecstasy: a literature review Drug Alcohol Rev. 21 2002 53 63
30. A. Gratton, B.J. Hoffer, and G.A. Gerhardt In vivo electrochemical studies of monoamine release in the medial prefrontal cortex of the rat Neuroscience 29 1989 57 64
31. A.R. Green, A.J. Cross, and G.M. Goodwin Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") Psychopharmacology (Berl) 119 1995 247 260
32. G.A. Gudelsky, and J.F. Nash Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions J. Neurochem. 66 1996 243 249
33. K.M. Hegadoren, M.T. Martin-Iverson, and G.B. Baker Comparative behavioural and neurochemical studies with a psychomotor stimulant, an hallucinogen and 3,4-methylenedioxy analogues of amphetamine Psychopharmacology (Berl) 118 1995 295 304
34. K.M. Hegadoren, G.B. Baker, and M. Bourin 3,4-Methylenedioxy analogues of amphetamine: defining the risks to humans Neurosci. Biobehav. Rev. 23 1999 539 553
35. A.F. Hoffman, C.R. Lupica, and G.A. Gerhardt Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices J. Pharmacol. Exp. Ther. 287 1998 487 496
36. A.F. Hoffman, and G.A. Gerhardt Differences in pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study J. Pharmacol. Exp. Ther. 289 1999 45
37. X. Huang, D. Marona-Lewicka, and D.E. Nichols p-Methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent Eur. J. Pharmacol. 229 1992 31 38
38. M.M. Iravani, D. Asari, J. Patel, W.J. Wieczorek, and Z.L. Kruk Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin or dopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulata, and the dorsal raphe nucleus slices Synapse 36 2000 275 285
39. B.P. Jackson, and R.M. Wightman Dynamics of 5-hydroxytryptamine released from dopamine neurons in the caudate putamen of the rat Brain Res. 674 1995 163 166
40. R.A. James, and A. Dinan Hyperpyrexia associated with fatal paramethoxyamphetamine (PMA) abuse Med. Sci. Law 38 1998 83 85
41. 3H]dopamine release from superfused rat brain slices Eur. J. Pharmacol. 132 1986 269 276
42. 3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues Eur. J. Pharmacol. 200 1991 9 16
43. L.M. Kaminskas, R.J. Irvine, P.D. Callaghan, J.M. White, and P. Kirkbride The contribution of the metabolite p-hydroxyamphetamine to the central actions of p-methoxyamphetamine Psychopharmacology 160 2002 155 160
44. A. Kankaanpaa, E. Meririnne, P. Lillsunde, and T. Seppala The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens Pharmacol. Biochem. Behav. 59 1998 1003 1009
45. K.T. Kawagoe, P.A. Garris, D.J. Wiedemann, and R.M. Wightman Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum Neuroscience 51 1992 55 64
46. S. Koch, and M.P. Galloway MDMA induced dopamine release in vivo: role of endogenous serotonin J. Neural. Transm. 104 1997 135 146
47. J.C. Kraner, D.J. McCoy, M.A. Evans, L.E. Evans, and B.J. Sweeney Fatalities caused by the MDMA-related drug paramethoxyamphetamine (PMA) J. Anal. Toxicol. 25 2001 645 648
48. L.H. Ling, C. Marchant, N.A. Buckley, M. Prior, and R.J. Irvine Poisoning with the recreational drug paramethoxyamphetamine ("death") Med. J. Aust. 174 2001 453 455
49. D. Marona-Lewicka, G.-S. Rhee, J.E. Sprague, and D.E. Nichols Reinforcing effects of certain serotonin-releasing amphetamine derivatives Pharmacol. Biochem. Behav. 53 1996 99 105
50. T.L. Martin Three cases of fatal paramethoxyamphetamine overdose J. Anal. Toxicol. 25 2001 649 651
51. L.J. May, and R.M. Wightman Heterogeneity of stimulated dopamine overflow within rat striatum as observed with in vivo voltammetry Brain Res. 487 1989 311 320
52. M.K. Menon, L.F. Tseng, and H.H. Loh Pharmacological evidence for the central serotonergic effects of monomethoxyamphetamines J. Pharmacol. Exp. Ther. 197 1976 272 279
53. S. Montañez, L.C. Daws, G.G. Gould, G.A. Gerhardt, and A. Frazer Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region Brain Res. 955 2002 236 244
54. S. Montañez, W.A. Owens, G.G. Gould, D.L. Murphy, and L.C. Daws Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice J. Neurochem. 86 2003 210 219
55. S. Montañez, L.C. Daws, G.G. Gould, and A. Frazer Serotonin transporter function after graded destruction of serotonergic neurons J. Neurochem. 87 2003 861 867
56. J.F. Nash Jr., and J. Brodkin Microdialysis studies on 3,4-methylenedioxymethamphetamine-induced dopamine release: effect of dopamine uptake inhibitors J. Pharmacol. Exp. Ther. 259 1991 820 825
57. J.F. Nash Jr., H.Y. Meltzer, and G.A. Gudelsky Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine J. Pharmacol. Exp. Ther. 245 1988 873 879
58. 3H]serotonin from rat brain synaptosomes J. Med. Chem. 25 1982 530 535
59. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, second ed., New York.
60. J. Sabeti, G.A. Gerhardt, and N.R. Zahniser Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats J. Pharmacol. Exp. Ther. 302 2002 1201 1211
61. L.S. Seiden, K.E. Sabol, and G.A. Ricuarte Amphetamine: Effects on catecholamine systems and behavior Ann. Rev. Pharmacol. Toxicol. 32 1993 639 677
62. J.J. Soghomonian, G. Doucet, and L. Descarries Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res. 425 1987 85 100
63. L.J. Spanos, and B.K. Yamamoto Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat Pharmacol. Biochem. Behav. 32 1989 835 840
64. J.A. Stamford, Z.L. Kruk, and J. Millar Striatal dopamine terminals release serotonin after 5-HTP pretreatment: in vivo voltammetric data Brain Res. 515 1990 173 180
65. 3H]monoamines into synaptosomes from different regions of rat brain Biochem. Pharmacol. 36 1987 2297 2303
66. D.M. Stone, D.C. Stahl, G.R. Hanson, and J.W. Gibb The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain Eur. J. Pharmacol. 128 1986 41 48
67. L.F. Tseng, R.J. Hitzemann, and H.H. Loh Comparative effects of dl-p-methoxyamphetamine and d-amphetamine on catecholamine release and reuptake in vitro J. Pharmacol. Exp. Ther. 189 1974 708 716
68. L.F. Tseng, and H.H. Loh Significance of dopamine receptor activity in dl-p-methoxyamphetamine- and d-amphetamine-induced locomotor activity J. Pharmacol. Exp. Ther. 189 1974 717 724
69. L.F. Tseng, M.K. Menon, and H.H. Loh Comparative actions of monomethoxyamphetamines on the release and uptake of biogenic amines in brain tissue J. Pharmacol. Exp. Ther. 197 1976 263 271
70. S. Voorspoels, V. Coucke, A. Covaci, J. Maervoet, P. Schepens, C. De Meyere, and W. Jacobs Resurgence of a lethal drug: paramethoxyamphetamine deaths in Belgium J. Toxicol. Clin. Toxicol. 40 2002 203 204
71. S.C. Wall, H. Gu, and G. Rudnick Biogenic amine flux mediated by cloned transporters stably expressed in cultured cell lines: Amphetamine specificity for inhibition and efflux Mol. Pharmacol. 47 1995 544 550
72. J.M. White, F. Bochner, and R.J. Irvine The agony of "ecstasy" Med. J. Aust. 166 1997 117 118
73. B.K. Yamamoto, J.F. Nash, and G.A. Gudelsky Modulation of methylenedioxymethamphetamine-induced striatal dopamine release by the interaction between serotonin and gamma-aminobutyric acid in the substantia nigra J. Pharmacol. Exp. Ther. 273 1995 1063 1070
74. B.K. Yamamoto, and S. Novotney Regulation of extracellular dopamine by the norepinephrine transporter J. Neurochem. 71 1998 274 280
75. B.K. Yamamoto, and E.A. Pehek A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis. Brain Res. 506 1990 236 242
76. B.K. Yamamoto, and L.J. Spanos The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat Eur. J. Pharmacol. 148 1988 195 203
77. F.C. Zhou, K.P. Lesch, and D.L. Murphy Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res. 942 2002 109 119