Reactive oxygen species are involved in nitric oxide-induced apoptosis of neurons

Progress in Biochemistry and Biophysics

Volumn 28, Issue 1, 2001, Pages 85-

  Zhang, Chun Yang ^a   Wei, Tao Tao ^b   Ma, Hui ^a   Ding, Yao ^a   Chen, Die Yan ^a   Hou, Jing Wu ^b   Chen, Chang ^b   Xin, Wen Juan ^b  

^a TSINGHUA UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Apoptosis; Glutathione; Laser confocal scanning microscopy; Nitric oxide; Primary rat cerebellar granule cells; Reactive oxygen species

Indexed keywords

EID: 21944445379     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Garthwaite J, Boulton C L. Nitric oxide signaling in the central nervous system. Annu Rev Physiol, 1995, 57: 683-706
2. Vidwans A S, Kim S, Coffin D O, et al. Analysis of the neuroprotective effects of various nitric oxide donor compounds in murin mixed cortical cell culture. J Neurochem, 1999, 72 (5): 1843-1852
3. Palluy O, Rigaud M. Nitric oxide induces cultured cortical neuron apoptosis. Neurosci Lett, 1996, 208 (1): 1-4
4. Bonfoco E, Leist M, Zhivotovsky B, et al. Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J Neurochem, 1996, 67 (6): 2484-2493
5. Gross S S, Wolin M S. Nitric oxide: Pathophysiology mechanisms. Annu Rev Physiol, 1995, 57: 737-769
6. Wei T T, Chen C, Hou B L, et al. Chin Sci Bul, 2000, 45 (5): 422-426
7. Wei T T, Chen C, Hou J W, et al. The antioxidant EPC-K1 attenuates NO-induced mitochondrial dysfunction, lipid peroxidation and apoptosis in cerebellar granule cells. Toxicology, 1999, 134 (2-3): 117-126
8. Li Y H, Maher P, Schubert D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron, 1997, 19 (2): 453-463
9. Teixeira H D, Schumacher R I, Meneghini R. Lower intracellular hydrogen peroxide levels in cells overexpressing CuZn-superoxide dismutase. Proc Natl Acad Sci USA, 1998, 95 (14): 7872-7875
10. Mark R J, Keller J N, Kruman I, et al. Basic FGF attanuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na, K-ATPase activity in hippocampal reurons. Brain Res, 1997, 756 (1-2): 205-214
11. Bolañ;os J P, Heales S J R, Peuchen S, et al. Nitric oxide-mediated mitochondrial damage: A potential neuropro-tective role for glutathione. Free Radic Biol Med, 1996, 21 (7): 995-1001
12. Grasbon-Frodl E M, Brundin P. Mesencephalic neuron death by congeners of nitrogen monoxide is prevented by the lazaroid U-83836E. Exp Brain Res, 1997, 113 (1): 138-143
13. Bolaños J P, Almeida A, Stewart V, et al. Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases. J Neurochem, 1997, 68 (6): 2227-2240
14. Poderoso J J, Carreras M C, Lisdero C, et al. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondria particles. Arch Biochem Biophys, 1996, 328 (1): 85-92
15. Beal M F. Mitochondria, free radicals, and neurodegeneration. Curr Opin Neurobiol, 1996, 6 (5): 661-666