-
1
-
-
0023573963
-
The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas
-
R. Abele, M. Clavel, P. Dodion The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas Eur J Cancer Clin Oncol 23 1987 1921 1924
-
(1987)
Eur J Cancer Clin Oncol
, vol.23
, pp. 1921-1924
-
-
Abele, R.1
Clavel, M.2
Dodion, P.3
-
2
-
-
0027141519
-
Number of CpG islands and genes in human and mouse
-
F. Antequera, A. Bird Number of CpG islands and genes in human and mouse Proc Natl Acad Sci U S A 90 1993 11995 11999
-
(1993)
Proc Natl Acad Sci U S a
, vol.90
, pp. 11995-11999
-
-
Antequera, F.1
Bird, A.2
-
3
-
-
0026623298
-
Synergistic cytotoxicity with 2′-deoxy-5-azacytidine and topotecan in vitro and in vivo
-
H. Anzai, P. Frost, J.L. Abbruzzese Synergistic cytotoxicity with 2′-deoxy-5-azacytidine and topotecan in vitro and in vivo Cancer Res 52 1992 2180 2185
-
(1992)
Cancer Res
, vol.52
, pp. 2180-2185
-
-
Anzai, H.1
Frost, P.2
Abbruzzese, J.L.3
-
4
-
-
0037924433
-
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
-
K.E. Bachman, B.H. Park, I. Rhee Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene Cancer Cell 3 2003 89 95
-
(2003)
Cancer Cell
, vol.3
, pp. 89-95
-
-
Bachman, K.E.1
Park, B.H.2
Rhee, I.3
-
7
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
-
E.E. Cameron, K.E. Bachman, S. Myohanen Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nat Genet 21 1999 103 107
-
(1999)
Nat Genet
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
-
8
-
-
0021715597
-
The tumorigenicity of 5-azacytidine in the male Fischer rat
-
B.I. Carr, J.G. Reilly, S.S. Smith The tumorigenicity of 5-azacytidine in the male Fischer rat Carcinogenesis 5 1984 1583 1590
-
(1984)
Carcinogenesis
, vol.5
, pp. 1583-1590
-
-
Carr, B.I.1
Reilly, J.G.2
Smith, S.S.3
-
9
-
-
0004959517
-
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex
-
S. Charache, G. Dover, K. Smith Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex Proc Natl Acad Sci U S A 80 1983 4842 4846
-
(1983)
Proc Natl Acad Sci U S a
, vol.80
, pp. 4842-4846
-
-
Charache, S.1
Dover, G.2
Smith, K.3
-
10
-
-
0029025475
-
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia
-
S. Charache, M.L. Terrin, R.D. Moore Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia N Engl J Med 332 1995 1317 1322
-
(1995)
N Engl J Med
, vol.332
, pp. 1317-1322
-
-
Charache, S.1
Terrin, M.L.2
Moore, R.D.3
-
11
-
-
0026572102
-
5-Aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group
-
M. Clavel, S. Monfardini, S. Fossa 5-Aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group Ann Oncol 3 1992 399 400
-
(1992)
Ann Oncol
, vol.3
, pp. 399-400
-
-
Clavel, M.1
Monfardini, S.2
Fossa, S.3
-
12
-
-
0037108309
-
Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′-deoxycytidine (decitabine) treatment
-
M. Daskalakis, T.T. Nguyen, C. Nguyen Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-aza-2′- deoxycytidine (decitabine) treatment Blood 100 2002 2957 2964
-
(2002)
Blood
, vol.100
, pp. 2957-2964
-
-
Daskalakis, M.1
Nguyen, T.T.2
Nguyen, C.3
-
13
-
-
12444297637
-
Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
-
A.J. Davis, K.A. Gelmon, L.L. Siu Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks Invest New Drugs 21 2003 85 97
-
(2003)
Invest New Drugs
, vol.21
, pp. 85-97
-
-
Davis, A.J.1
Gelmon, K.A.2
Siu, L.L.3
-
14
-
-
0344211845
-
Long-term follow-up of a phase I study of high-dose decitabine, busulfan, and cyclophosphamide plus allogeneic transplantation for the treatment of patients with leukemias
-
M. de Lima, F. Ravandi, M. Shahjahan Long-term follow-up of a phase I study of high-dose decitabine, busulfan, and cyclophosphamide plus allogeneic transplantation for the treatment of patients with leukemias Cancer 97 2003 1242 1247
-
(2003)
Cancer
, vol.97
, pp. 1242-1247
-
-
De Lima, M.1
Ravandi, F.2
Shahjahan, M.3
-
15
-
-
0000206049
-
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
-
J. DeSimone, P. Heller, L. Hall 5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons Proc Natl Acad Sci U S A 79 1982 4428 4431
-
(1982)
Proc Natl Acad Sci U S a
, vol.79
, pp. 4428-4431
-
-
Desimone, J.1
Heller, P.2
Hall, L.3
-
16
-
-
0021987734
-
Tetrahydrouridine, cytidine analogues, and hemoglobin F
-
J. DeSimone, P. Heller, R.E. Molokie Tetrahydrouridine, cytidine analogues, and hemoglobin F Am J Hematol 18 1985 283 288
-
(1985)
Am J Hematol
, vol.18
, pp. 283-288
-
-
Desimone, J.1
Heller, P.2
Molokie, R.E.3
-
17
-
-
0036625004
-
Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia
-
J. DeSimone, M. Koshy, L. Dorn Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia Blood 99 2002 3905 3908
-
(2002)
Blood
, vol.99
, pp. 3905-3908
-
-
Desimone, J.1
Koshy, M.2
Dorn, L.3
-
18
-
-
3042728781
-
Phase II trial of oral suberoylanilide hydroxamic acid (SAHA) for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL)
-
M. Duvic, R. Talpur, N. Chiao Phase II trial of oral suberoylanilide hydroxamic acid (SAHA) for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) Blood 102 2003 179a (abstr)
-
(2003)
Blood
, vol.102
-
-
Duvic, M.1
Talpur, R.2
Chiao, N.3
-
19
-
-
0037115392
-
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer
-
J.A. Fahrner, S. Eguchi, J.G. Herman Dependence of histone modifications and gene expression on DNA hypermethylation in cancer Cancer Res 62 2002 7213 7218
-
(2002)
Cancer Res
, vol.62
, pp. 7213-7218
-
-
Fahrner, J.A.1
Eguchi, S.2
Herman, J.G.3
-
20
-
-
7744235007
-
Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2′-deoxycytidine
-
X. Fang, C. Zheng, Z. Liu Enhanced sensitivity of prostate cancer DU145 cells to cisplatinum by 5-aza-2′-deoxycytidine Oncol Rep 12 2004 523 526
-
(2004)
Oncol Rep
, vol.12
, pp. 523-526
-
-
Fang, X.1
Zheng, C.2
Liu, Z.3
-
21
-
-
0025294204
-
Synergistic cytotoxicity using 2′-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells
-
P. Frost, J.L. Abbruzzese, B. Hunt Synergistic cytotoxicity using 2′-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells Cancer Res 50 1990 4572 4577
-
(1990)
Cancer Res
, vol.50
, pp. 4572-4577
-
-
Frost, P.1
Abbruzzese, J.L.2
Hunt, B.3
-
22
-
-
0033988813
-
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
-
F. Fuks, W.A. Burgers, A. Brehm DNA methyltransferase Dnmt1 associates with histone deacetylase activity Nat Genet 24 2000 88 91
-
(2000)
Nat Genet
, vol.24
, pp. 88-91
-
-
Fuks, F.1
Burgers, W.A.2
Brehm, A.3
-
23
-
-
0035992430
-
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia
-
G. Garcia-Manero, J. Daniel, T.L. Smith DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia Clin Cancer Res 8 2002 2217 2224
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2217-2224
-
-
Garcia-Manero, G.1
Daniel, J.2
Smith, T.L.3
-
24
-
-
33344456652
-
Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents
-
(in press)
-
Garcia-Manero G, Issa JP: Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents. Cancer Invest (in press)
-
Cancer Invest
-
-
Garcia-Manero, G.1
Issa, J.P.2
-
25
-
-
5744246471
-
Phase I study of oral suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, in patients with advanced leukemias or myelodysplastic syndromes (MDS)
-
G. Garcia-Manero, J.P. Issa, J. Cortes Phase I study of oral suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, in patients with advanced leukemias or myelodysplastic syndromes (MDS) Proc Am Soc Clin Oncol 23 2004 201 (abstr)
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 201
-
-
Garcia-Manero, G.1
Issa, J.P.2
Cortes, J.3
-
26
-
-
0037303688
-
Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia
-
G. Garcia-Manero, S. Jeha, J. Daniel Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia Cancer 97 2003 695 702
-
(2003)
Cancer
, vol.97
, pp. 695-702
-
-
Garcia-Manero, G.1
Jeha, S.2
Daniel, J.3
-
28
-
-
20344393986
-
Results of a phase I/II study of the combination of 5-aza-2′- deoxycytidine (DAC) and valproic acid (VPA) in patients with leukemia
-
G. Garcia-Manero, H.M. Kantarjian, B. Sanchez-Gonzales Results of a phase I/II study of the combination of 5-aza-2′-deoxycytidine (DAC) and valproic acid (VPA) in patients with leukemia Blood 104 2004 263
-
(2004)
Blood
, vol.104
, pp. 263
-
-
Garcia-Manero, G.1
Kantarjian, H.M.2
Sanchez-Gonzales, B.3
-
29
-
-
21844444900
-
Changes in promoter methylation and gene expression in patients with MDS and MDs-AML treated with 5-azacytidine and sodium phenylbutyrate
-
S. Gore, S.B. Baylin, T. Dauses Changes in promoter methylation and gene expression in patients with MDS and MDs-AML treated with 5-azacytidine and sodium phenylbutyrate Blood 104 2004 469 (abstr)
-
(2004)
Blood
, vol.104
, pp. 469
-
-
Gore, S.1
Baylin, S.B.2
Dauses, T.3
-
30
-
-
0033672431
-
Modifying histones to tame cancer: Clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors
-
S.D. Gore, M.A. Carducci Modifying histones to tame cancer clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors Expert Opin Investig Drugs 9 2000 2923 2934
-
(2000)
Expert Opin Investig Drugs
, vol.9
, pp. 2923-2934
-
-
Gore, S.D.1
Carducci, M.A.2
-
31
-
-
0030861882
-
Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells
-
S.D. Gore, D. Samid, L.J. Weng Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells Clin Cancer Res 3 1997 1755 1762
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1755-1762
-
-
Gore, S.D.1
Samid, D.2
Weng, L.J.3
-
32
-
-
0034880682
-
Impact of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia
-
S.D. Gore, L.J. Weng, S. Zhai Impact of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia Clin Cancer Res 7 2001 2330 2339
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2330-2339
-
-
Gore, S.D.1
Weng, L.J.2
Zhai, S.3
-
33
-
-
18244383806
-
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
-
M. Gottlicher, S. Minucci, P. Zhu Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells EMBO J 20 2001 6969 6978
-
(2001)
EMBO J
, vol.20
, pp. 6969-6978
-
-
Gottlicher, M.1
Minucci, S.2
Zhu, P.3
-
34
-
-
0035032345
-
A tale of histone modifications
-
P.A. Grant A tale of histone modifications Genome Biol 2 2001 REVIEW0003
-
(2001)
Genome Biol
, vol.2
, pp. 0003
-
-
Grant, P.A.1
-
35
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
J.G. Herman, S.B. Baylin Gene silencing in cancer in association with promoter hypermethylation N Engl J Med 349 2003 2042 2054
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
36
-
-
0035328527
-
Accelerated age-related CpG island methylation in ulcerative colitis
-
J.P. Issa, N. Ahuja, M. Toyota Accelerated age-related CpG island methylation in ulcerative colitis Cancer Res 61 2001 3573 3577
-
(2001)
Cancer Res
, vol.61
, pp. 3573-3577
-
-
Issa, J.P.1
Ahuja, N.2
Toyota, M.3
-
37
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
J.P. Issa, G. Garcia-Manero, F.J. Giles Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies Blood 103 2004 1635 1640
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
-
38
-
-
32644459379
-
Hypomethylation dynamics following decitabine therapy in chronic myelogenous leukemia
-
J.P. Issa, V. Gharibyan, J. Jelinek Hypomethylation dynamics following decitabine therapy in chronic myelogenous leukemia Blood 103 2004 A2956 (abstr)
-
(2004)
Blood
, vol.103
, pp. 2956
-
-
Issa, J.P.1
Gharibyan, V.2
Jelinek, J.3
-
39
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
P.A. Jones, S.B. Baylin The fundamental role of epigenetic events in cancer Nat Rev Genet 3 2002 415 428
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
40
-
-
0037962005
-
Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
-
H.M. Kantarjian, S. O'Brien, J. Cortes Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia Cancer 98 2003 522 528
-
(2003)
Cancer
, vol.98
, pp. 522-528
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.3
-
41
-
-
0033598843
-
Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells
-
A.R. Karpf, P.W. Peterson, J.T. Rawlins Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells Proc Natl Acad Sci U S A 96 1999 14007 14012
-
(1999)
Proc Natl Acad Sci U S a
, vol.96
, pp. 14007-14012
-
-
Karpf, A.R.1
Peterson, P.W.2
Rawlins, J.T.3
-
42
-
-
0242330341
-
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine
-
J.C. Keen, L. Yan, K.M. Mack A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine Breast Cancer Res Treat 81 2003 177 186
-
(2003)
Breast Cancer Res Treat
, vol.81
, pp. 177-186
-
-
Keen, J.C.1
Yan, L.2
MacK, K.M.3
-
43
-
-
0037215568
-
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer
-
Y. Kondo, L. Shen, J.P. Issa Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer Mol Cell Biol 23 2003 206 215
-
(2003)
Mol Cell Biol
, vol.23
, pp. 206-215
-
-
Kondo, Y.1
Shen, L.2
Issa, J.P.3
-
44
-
-
0034307656
-
2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
-
M. Koshy, L. Dorn, L. Bressler 2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia Blood 96 2000 2379 2384
-
(2000)
Blood
, vol.96
, pp. 2379-2384
-
-
Koshy, M.1
Dorn, L.2
Bressler, L.3
-
45
-
-
7644240657
-
The role of fetal hemoglobin-enhancing agents in thalassemia
-
A. Lal, E. Vichinsky The role of fetal hemoglobin-enhancing agents in thalassemia Semin Hematol 41 2004 17 22
-
(2004)
Semin Hematol
, vol.41
, pp. 17-22
-
-
Lal, A.1
Vichinsky, E.2
-
46
-
-
0343027909
-
Reversal of cisplatinum resistance by 5-aza-2′-aza-deoxycytidine (DAC) in human ovarian cell lines
-
R. Lenzi, J.L. Abbruzzese, B. Hunt Reversal of cisplatinum resistance by 5-aza-2′-aza-deoxycytidine (DAC) in human ovarian cell lines Proc Am Assoc Cancer Res 33 1992 497 (abstr)
-
(1992)
Proc Am Assoc Cancer Res
, vol.33
, pp. 497
-
-
Lenzi, R.1
Abbruzzese, J.L.2
Hunt, B.3
-
47
-
-
0027274649
-
Brief report: Treatment with azacitidine of patients with end-stage beta-thalassemia
-
C.H. Lowrey, A.W. Nienhuis Brief report Treatment with azacitidine of patients with end-stage beta-thalassemia N Engl J Med 329 1993 845 848
-
(1993)
N Engl J Med
, vol.329
, pp. 845-848
-
-
Lowrey, C.H.1
Nienhuis, A.W.2
-
48
-
-
3042854223
-
Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients
-
F. Lyko, D. Stach, A. Brenner Quantitative analysis of DNA methylation in chronic lymphocytic leukemia patients Electrophoresis 25 2004 1530 1535
-
(2004)
Electrophoresis
, vol.25
, pp. 1530-1535
-
-
Lyko, F.1
Stach, D.2
Brenner, A.3
-
49
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
P. Marks, R.A. Rifkind, V.M. Richon Histone deacetylases and cancer causes and therapies Nat Rev Cancer 1 2001 194 202
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
-
50
-
-
0021034956
-
Molecular mechanisms of human hemoglobin switching: Selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts
-
F. Mavilio, A. Giampaolo, A. Care Molecular mechanisms of human hemoglobin switching selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts Proc Natl Acad Sci U S A 80 1983 6907 6911
-
(1983)
Proc Natl Acad Sci U S a
, vol.80
, pp. 6907-6911
-
-
Mavilio, F.1
Giampaolo, A.2
Care, A.3
-
51
-
-
0030974771
-
Pilot phase I-II study on 5-aza-2′-deoxycytidine (decitabine) in patients with metastatic lung cancer
-
R.L. Momparler, D.Y. Bouffard, L.F. Momparler Pilot phase I-II study on 5-aza-2′-deoxycytidine (decitabine) in patients with metastatic lung cancer Anticancer Drugs 8 1997 358 368
-
(1997)
Anticancer Drugs
, vol.8
, pp. 358-368
-
-
Momparler, R.L.1
Bouffard, D.Y.2
Momparler, L.F.3
-
52
-
-
0037112369
-
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′- deoxycytidine
-
C.T. Nguyen, D.J. Weisenberger, M. Velicescu Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2′-deoxycytidine Cancer Res 62 2002 6456 6461
-
(2002)
Cancer Res
, vol.62
, pp. 6456-6461
-
-
Nguyen, C.T.1
Weisenberger, D.J.2
Velicescu, M.3
-
53
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
S.G. O'Brien, F. Guilhot, R.A. Larson Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia N Engl J Med 348 2003 994 1004
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
54
-
-
0036338205
-
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin
-
A.H. Peters, J.E. Mermoud, D. O'Carroll Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin Nat Genet 30 2002 77 80
-
(2002)
Nat Genet
, vol.30
, pp. 77-80
-
-
Peters, A.H.1
Mermoud, J.E.2
O'Carroll, D.3
-
55
-
-
0035965343
-
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
-
C.J. Phiel, F. Zhang, E.Y. Huang Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen J Biol Chem 276 2001 36734 36741
-
(2001)
J Biol Chem
, vol.276
, pp. 36734-36741
-
-
Phiel, C.J.1
Zhang, F.2
Huang, E.Y.3
-
56
-
-
2942535832
-
T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: Impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance
-
R.L. Piekarz, R.W. Robey, Z. Zhan T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance Blood 103 2004 4636 4643
-
(2004)
Blood
, vol.103
, pp. 4636-4643
-
-
Piekarz, R.L.1
Robey, R.W.2
Zhan, Z.3
-
57
-
-
0035866341
-
Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis
-
R. Pili, M.P. Kruszewski, B.W. Hager Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis Cancer Res 61 2001 1477 1485
-
(2001)
Cancer Res
, vol.61
, pp. 1477-1485
-
-
Pili, R.1
Kruszewski, M.P.2
Hager, B.W.3
-
58
-
-
0036794950
-
Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix
-
P. Pohlmann, L.P. DiLeone, A.I. Cancella Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix Am J Clin Oncol 25 2002 496 501
-
(2002)
Am J Clin Oncol
, vol.25
, pp. 496-501
-
-
Pohlmann, P.1
Dileone, L.P.2
Cancella, A.I.3
-
60
-
-
0034940793
-
Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant: Results of a phase I study
-
F. Ravandi, H. Kantarjian, A. Cohen Decitabine with allogeneic peripheral blood stem cell transplantation in the therapy of leukemia relapse following a prior transplant Results of a phase I study Bone Marrow Transplant 27 2001 1221 1225
-
(2001)
Bone Marrow Transplant
, vol.27
, pp. 1221-1225
-
-
Ravandi, F.1
Kantarjian, H.2
Cohen, A.3
-
61
-
-
0034305821
-
DNA methylation in health and disease
-
K.D. Robertson, A.P. Wolffe DNA methylation in health and disease Nat Rev Genet 1 2000 11 19
-
(2000)
Nat Rev Genet
, vol.1
, pp. 11-19
-
-
Robertson, K.D.1
Wolffe, A.P.2
-
62
-
-
21844463655
-
First report of the phase III North American trial of decitabine in advanced myelodysplastic syndrome (MDS)
-
H. Saba, C. Rosenfled, J.P. Issa First report of the phase III North American trial of decitabine in advanced myelodysplastic syndrome (MDS) Blood 104 2004 64 (abstr)
-
(2004)
Blood
, vol.104
, pp. 64
-
-
Saba, H.1
Rosenfled, C.2
Issa, J.P.3
-
63
-
-
7644223139
-
Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease
-
Y. Saunthararajah, J. DeSimone Clinical studies with fetal hemoglobin-enhancing agents in sickle cell disease Semin Hematol 41 2004 11 16
-
(2004)
Semin Hematol
, vol.41
, pp. 11-16
-
-
Saunthararajah, Y.1
Desimone, J.2
-
64
-
-
10744231450
-
Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease
-
Y. Saunthararajah, C.A. Hillery, D. Lavelle Effects of 5-aza-2′-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease Blood 102 2003 3865 3870
-
(2003)
Blood
, vol.102
, pp. 3865-3870
-
-
Saunthararajah, Y.1
Hillery, C.A.2
Lavelle, D.3
-
66
-
-
0030990163
-
Decitabine (5-aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations
-
G. Schwartsmann, M.S. Fernandes, M.D. Schaan Decitabine (5-aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia Preliminary observations Leukemia 11 suppl 1 1997 S28 S31
-
(1997)
Leukemia
, vol.11
, Issue.1 SUPPL.
-
-
Schwartsmann, G.1
Fernandes, M.S.2
Schaan, M.D.3
-
67
-
-
0034106513
-
A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
-
G. Schwartsmann, H. Schunemann, C.N. Gorini A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer Invest New Drugs 18 2000 83 91
-
(2000)
Invest New Drugs
, vol.18
, pp. 83-91
-
-
Schwartsmann, G.1
Schunemann, H.2
Gorini, C.N.3
-
68
-
-
0025355878
-
Phase II study of 5-aza-2′-deoxycytidine in advanced ovarian carcinoma. the EORTC Early Clinical Trials Group
-
C. Sessa, W. ten Bokkel Huinink, G. Stoter Phase II study of 5-aza-2′-deoxycytidine in advanced ovarian carcinoma. The EORTC Early Clinical Trials Group Eur J Cancer 26 1990 137 138
-
(1990)
Eur J Cancer
, vol.26
, pp. 137-138
-
-
Sessa, C.1
Ten Bokkel Huinink, W.2
Stoter, G.3
-
69
-
-
0037625237
-
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia
-
L. Shen, M. Toyota, Y. Kondo Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia Blood 101 2003 4131 4136
-
(2003)
Blood
, vol.101
, pp. 4131-4136
-
-
Shen, L.1
Toyota, M.2
Kondo, Y.3
-
70
-
-
10844289762
-
Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2′-deoxycytidine
-
L. Sigalotti, E. Fratta, S. Coral Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2′-deoxycytidine Cancer Res 64 2004 9167 9171
-
(2004)
Cancer Res
, vol.64
, pp. 9167-9171
-
-
Sigalotti, L.1
Fratta, E.2
Coral, S.3
-
71
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the Cancer and Leukemia Group B
-
L.R. Silverman, E.P. Demakos, B.L. Peterson Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome A study of the Cancer and Leukemia Group B J Clin Oncol 20 2002 2429 2440
-
(2002)
J Clin Oncol
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
72
-
-
0033564902
-
DNA methylation
-
R. Singal, G.D. Ginder DNA methylation Blood 93 1999 4059 4070
-
(1999)
Blood
, vol.93
, pp. 4059-4070
-
-
Singal, R.1
Ginder, G.D.2
-
73
-
-
0034610814
-
The language of covalent histone modifications
-
B.D. Strahl, C.D. Allis The language of covalent histone modifications Nature 403 2000 41 45
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
74
-
-
0023821768
-
Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints
-
D.A. Tagle, B.F. Koop, M. Goodman Embryonic epsilon and gamma globin genes of a prosimian primate (Galago crassicaudatus). Nucleotide and amino acid sequences, developmental regulation and phylogenetic footprints J Mol Biol 203 1988 439 455
-
(1988)
J Mol Biol
, vol.203
, pp. 439-455
-
-
Tagle, D.A.1
Koop, B.F.2
Goodman, M.3
-
75
-
-
2442628250
-
DNA methylation profiles of lymphoid and hematopoietic malignancies
-
T. Takahashi, N. Shivapurkar, J. Reddy DNA methylation profiles of lymphoid and hematopoietic malignancies Clin Cancer Res 10 2004 2928 2935
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2928-2935
-
-
Takahashi, T.1
Shivapurkar, N.2
Reddy, J.3
-
76
-
-
0031945210
-
A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer
-
A. Thibault, W.D. Figg, R.C. Bergan A phase II study of 5-aza-2′deoxycytidine (decitabine) in hormone independent metastatic (D2) prostate cancer Tumori 84 1998 87 89
-
(1998)
Tumori
, vol.84
, pp. 87-89
-
-
Thibault, A.1
Figg, W.D.2
Bergan, R.C.3
-
77
-
-
0032739329
-
CpG island methylator phenotypes in aging and cancer
-
M. Toyota, J.P. Issa CpG island methylator phenotypes in aging and cancer Semin Cancer Biol 9 1999 349 357
-
(1999)
Semin Cancer Biol
, vol.9
, pp. 349-357
-
-
Toyota, M.1
Issa, J.P.2
-
78
-
-
0035353188
-
Methylation profiling in acute myeloid leukemia
-
M. Toyota, K.J. Kopecky, M.O. Toyota Methylation profiling in acute myeloid leukemia Blood 97 2001 2823 2829
-
(2001)
Blood
, vol.97
, pp. 2823-2829
-
-
Toyota, M.1
Kopecky, K.J.2
Toyota, M.O.3
-
79
-
-
0018905582
-
DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues
-
L.H. van der Ploeg, R.A. Flavell DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues Cell 19 1980 947 958
-
(1980)
Cell
, vol.19
, pp. 947-958
-
-
Van Der Ploeg, L.H.1
Flavell, R.A.2
-
80
-
-
0026018911
-
5-Aza-2′-deoxycytidine in advanced or recurrent cancer of the uterine cervix
-
J.B. Vermorken, S. Tumolo, K.J. Roozendaal 5-Aza-2′-deoxycytidine in advanced or recurrent cancer of the uterine cervix Eur J Cancer 27 1991 216 217
-
(1991)
Eur J Cancer
, vol.27
, pp. 216-217
-
-
Vermorken, J.B.1
Tumolo, S.2
Roozendaal, K.J.3
-
82
-
-
17444452612
-
Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
-
P. Wijermans, M. Lubbert, G. Verhoef Low-dose 5-aza-2′- deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome A multicenter phase II study in elderly patients J Clin Oncol 18 2000 956 962
-
(2000)
J Clin Oncol
, vol.18
, pp. 956-962
-
-
Wijermans, P.1
Lubbert, M.2
Verhoef, G.3
-
83
-
-
0030965033
-
A randomized phase II study on the effects of 5-aza-2′- deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: An EORTC Leukemia Cooperative Group phase II study (06893)
-
R. Willemze, S. Suciu, E. Archimbaud A randomized phase II study on the effects of 5-aza-2′-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia An EORTC Leukemia Cooperative Group phase II study (06893) Leukemia 11 suppl 1 1997 S24 S27
-
(1997)
Leukemia
, vol.11
, Issue.1 SUPPL.
-
-
Willemze, R.1
Suciu, S.2
Archimbaud, E.3
-
84
-
-
20344394418
-
Antileukemia activity of the combination of 5-aza-2′-deoxycytidine with valproic acid
-
H. Yang, K. Hoshino, B. Sanchez-Gonzalez Antileukemia activity of the combination of 5-aza-2′-deoxycytidine with valproic acid Leuk Res 29 2005 739 748
-
(2005)
Leuk Res
, vol.29
, pp. 739-748
-
-
Yang, H.1
Hoshino, K.2
Sanchez-Gonzalez, B.3
|