Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration

Journal of Neuroscience

Volumn 21, Issue 8, 2001, Pages 2889-2896

  Kirik, D ^a   Winkler, C ^a   Bjorklund A ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

6 Hydroxydopamine; Parkinson's disease; Paw use; Sensorimotor behavior; Stepping; Stereology; Transplantation; Tyrosine hydroxylase

Indexed keywords

OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; FEMALE; FOREBRAIN; MESENCEPHALON; NERVE CELL GROWTH; NERVE FIBER GROWTH; NERVE TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STRIATONIGRAL DEGENERATION;

EID: 0035871386     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-08-02889.2001     Document Type: Article

References (33)

1. Biochemistry of neurotransmitters in Parkinson's disease
2. A comparison of the behavioural effects of embryonic nigral grafts in the caudate nucleus and in the putamen of marmosets with unilateral 6-OHDA lesions
3. Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites
4. Nigral transplants in the rat Parkinson model. Functional limitations and strategies to enhance nigrostriatal reconstruction
5. Striatal homogenates from animals chronically treated with haloperidol stimulate dopamine and GABA uptake in cultures of rostral mesencephalic tegmentum
6. Loss of striatal DA innervation increases striatal trophic activity directed at DA neurons in culture
7. Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: An argument for neurotrophic supplementation
8. Effect of prior dopamine denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts
9. The functional role of mesotelencephalic dopamine systems
10. Intracerebral grafting of neuronal cell suspensions. IV. Behavioural recovery in rats with unilateral 6-OHDA lesions following implantation of nigral cell suspensions in different forebrain sites
11. Enhanced synthesis of platelet-derived growth factor following injury induced by 6-hydroxydopamine in rat brain
12. The efficiency of systematic sampling in stereology and its prediction
13. Dopaminergic neural grafts after fifteen years: Results and perspectives
14. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
15. Striatal trophic activity is reduced in the aged rat brain
16. The importance of graft placement and task complexity for transplant-induced recovery of simple and complex sensorimotor deficits in dopamine denervated rats
17. The "staircase test": A measure of independent forelimb reaching and grasping abilities in rats
18. Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model
19. A microtransplantation approach for cell suspension grafting in the rat Parkinson model: A detailed account of the methodology
20. Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
21. Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
22. Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease
23. Intervention strategies for degeneration of dopamine neurons in Parkinsonism: Optimising behavioral assessment of outcome
24. A clinically relevant unilateral rat model of Parkinsonian akinesia
25. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease
26. Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
27. Unbiased stereological estimation of the total number of neurons of the rat hippocampus using the optical fractionator
28. Long distance directed axonal growth from human dopaminergic mesencephalic neuroblasts implanted along the nigrostriatal pathway in 6-hydroxydopamine lesioned adult rats
29. A glial cell line-derived neurotrophic factor-secreting clone of the Schwann cell line SCTM41 enhances survival and fiber outgrowth from embryonic nigral neurons grafted to the striatum and to the lesioned substantia nigra
30. Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants
31. Lesion-induced increase of BDNF is greater in the striatum of young versus old rat brain
32. BDNF enhances the functional reinnervation of the striatum by grafted fetal dopamine neurons
33. The BDNF content of postnatal and adult rat brain: The effects of 6-hydroxydopamine lesions in adult brain