Multiplicity adjustment for multiple endpoints in clinical trials with multiple doses of an active treatment

Statistics in Medicine

Volumn 24, Issue 14, 2005, Pages 2151-2170

  Quan, Hui ^a   Luo, Xiaohui ^a   Capizzi, Tom ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adjusted p value; Closed procedure; Family wise error rate; Strong control; Weak control

Indexed keywords

CORTICOSTEROID; MITOXANTRONE; PLACEBO;

ANALYTICAL ERROR; ARTICLE; CLINICAL TRIAL; DATA ANALYSIS; DOSE RESPONSE; HUMAN; HYPOTHESIS; MATHEMATICAL ANALYSIS; METHODOLOGY; MULTIPLE DRUG DOSE; MULTIPLE SCLEROSIS; MULTIVARIATE ANALYSIS; OUTCOMES RESEARCH; RATING SCALE; RELAPSE; REMISSION; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ANALGESICS; CLINICAL TRIALS, PHASE III; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY; HUMANS; MITOXANTRONE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; MULTIVARIATE ANALYSIS;

EID: 21844455777     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.2101     Document Type: Article

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