Multiple testing for identifying effective and safe treatments

Biometrical Journal

Volumn 43, Issue 5, 2001, Pages 605-616

  Bauer, Peter ^a   Brannath, Werner ^b   Posch, Martin ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b NONE

Author keywords

Multiple end points; Multiple level; Multiple subfamilies; Order relation; Power; Splitting

Indexed keywords

END-POINTS; MULTIPLE END POINT; MULTIPLE LEVELS; MULTIPLE SUBFAMILY; MULTIPLE TESTING; NULL HYPOTHESIS; ORDERING RELATIONS; POWER; SPLITTINGS; Α-SPLITTING;

EID: 0035631642     PISSN: 03233847     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4036(200109)43:5<605::AID-BIMJ605>3.0.CO;2-V     Document Type: Article

References (26)

1. BARTHOLOMEW, D. J., 1959: A test of homogeneity for ordered alternatives. Biometrika, 46, 34-38.
2. BAUER, P., 1991: Multiple testing in clinical trials. Statistics in Medicine 10, 871-890.
3. BAUER, P. and BUDDE, M., 1994: Multiple testing for detecting efficient dose steps. Biom. J. 36, 3-15.
4. BAUER, P. and KIESER, M., 1996: A unifying approach for confidence intervals and testing of equivalence and difference. Biometrika 83, 934-937.
5. BAUER, P., RÖHMEL, J., MAURER, W., and HOTHORN, L., 1998: Testing strategies in multi-dose experiments including active control. Statistics in Medicine 17, 2133-2146.
6. CHANNON, E. J., 2000: Equivalence testing in dose-response studies. Drug Information Journal, 34, 551-562.
7. D'AGOSTINO, R. B., MASSARO, J., HWAN, H., and CABRAL, H., 1993: Strategies for dealing with multiple comparisons in confirmatory clinical trials. Drug Information Journal 27, 625-641.
8. DUNNETT, C. W., 1955: A multiple comparison procedure for comparing several treatments with a control. Journal of the American Statistical Association 50, 1096-1121.
9. DUNNETT, C. W. and TAMHANE, A. C., 1992: Comparison between a new drug and active and placebo control in an efficacy clinical trial. Statistics in Medicine 11, 1057-1063.
10. FINNER, H., 1988: Abgeschlossene multiple Spannweitentests. In Bauer, P., Hommel, G., and Sonnemann, E. (eds), Multiple Hypotheses Testing. Symposium Gerolstein, Springer-Verlag, Heidelberg.
11. HOTHORN, L. A. and HAUSCHKE, D., 2000: Identifying the maximum safe dose: a multiple testing approach. J. Biopharm. Statistics 10, 15-30.
12. HOTHORN, L. A., NEUHAEUSER, M., and KOCH, H.-F., 1997: Analysis of randomized dose-finding-studies: Closure test modifications based on multiple contrast tests. Biom. J. 39, 4, 467-479.
13. ICH, 1998: International Conference on Harmonization: Note for guidance on statistical principles for clinical trials. EMEA, http://www.eudra.org.
14. MAJOR, P., LORTHOLARY, A., HON, J., ABDI, E., MILLS, G., MENSSEN, H. D., YUNUS, F., BELL, R., BODY, J., QUEBE-FEHLING, E., and SEAMAN, J., 2001: Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials. Journal of Clinical Incology 19 (2) 558-567.
15. MARCUS, R., PERITZ, E., and GABRIEL, K.R., 1976: On closed testing procedures with special reference to ordered analysis of variance. Biometrika 63, 655-660.
16. MAURER, W., HOTHORN, L. A., and LEHMACHER, W., 1995: Multiple comparisons in drug clinical trials and preclinical assays: a-priori ordered hypotheses. In Vollmar, J. (ed.): Biometrie in der chemisch-pharmazeutischen Biometrie, Vol. 6. Fischer-Verlag, Stuttgart, pp. 3-18.
17. MUKERJEE, H., ROBERTSON, T., and WRIGHT, F. T., 1986: Multiple contrast tests for testing against a simple tree ordering. Advances in order restricted statistical inference, Proc. Symp. Iowa City/ Iowa 1985, Lect. Notes Stat., Springer-Verlag, Berlin, 37, 203-230.
18. NAIK, U.D., 1975: Some selection rules for comparing p processes with a standard. Communications in Statistics - Theory and Methods 4, 519-535.
19. REITMEIR, P. and WASSMER, G., 1999: Resampling-based methods for the analysis of multiple end-points in clinical trials. Statistics in Medicine 18, 3453-3462.
20. SCHEFFÉ, H., 1953: A method for judging all contrasts in the analysis of variance. Biometrika 40, 87-104.
21. SONNEMANN, E., FINNER, H., and KUNERT, J., 1986: Analyse von Verlaufskurven. Biometriekurs. Universität Trier.
22. TAMHANE, A. C., HOCHBERG, Y., and DUNNETT, C. W., 1996: Multiple test procedures for dose finding. Biometrics 52, 1, 21-37.
23. TUKEY, J. W., 1952: Allowances for Various Types of Error Rates. Unpublished IMS address, Chicago, IL.
24. WESTFALL, P. H. and YOUNG, S. S., 1993: Resampling-based multiple testing. John Wiley & Sons, New York.
25. WILLIAMS, D. A., 1971: A test for difference between treatment means when several dose levels are compared with a zero dose control. Biometrics 27, 103-117.
26. WILLIAMS, D. A., 1972: The comparison of several dose levels with a zero dose control. Biometrics 28, 519-531.